Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Stanislav Miertuš"'
Autor:
Koffi N’Guessan Placide Gabin Allangba, Mélalie Keita, Raymond Kre N’Guessan, Eugene Megnassan, Vladimir Frecer, Stanislav Miertus
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 547-561 (2019)
We report computer-aided design of new lactone–chalcone and isatin–chalcone (HLCIC) inhibitors of the falcipain-2 (PfFP-2). 3D models of 15 FP-2:HLCIC1-15 complexes with known observed activity (IC50exp) were prepared to establish a quantitative
Externí odkaz:
https://doaj.org/article/81ff42822d174810b7d71172ba3115fa
Autor:
Affiba Florance Kouassi, Mawa Kone, Melalie Keita, Akori Esmel, Eugene Megnassan, Yao Thomas N’Guessan, Vladimir Frecer, Stanislav Miertus
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 12, Pp 29744-29771 (2015)
We have carried out a computational structure-based design of new potent pyrrolidine carboxamide (PCAMs) inhibitors of enoyl-acyl carrier protein reductase (InhA) of Mycobacterium tuberculosis (MTb). Three-dimensional (3D) models of InhA-PCAMx comple
Externí odkaz:
https://doaj.org/article/6e60de8f8f6e40a98c9bf3822dc818ab
Autor:
Ivana Nemčovičová, Katarína Lopušná, Iveta Štibrániová, Fabio Benedetti, Federico Berti, Fulvia Felluga, Sara Drioli, Mattia Vidali, Jaroslav Katrlík, Lucia Pažitná, Alena Holazová, Jana Blahutová, Simona Lenhartová, Monika Sláviková, Boris Klempa, Miroslav Ondrejovič, Daniela Chmelová, Barbora Legerská, Stanislav Miertuš, Mária Klacsová, Daniela Uhríková, Lukáš Kerti, Vladimír Frecer
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractThe viral genome of the SARS-CoV-2 coronavirus, the aetiologic agent of COVID-19, encodes structural, non-structural, and accessory proteins. Most of these components undergo rapid genetic variations, though to a lesser extent the essential v
Externí odkaz:
https://doaj.org/article/1ab0d8cfa120432f8905bf2f4c7f5d07
Autor:
Fabio Benedetti, Federico Berti, Stanislav Miertus, Domenico Romeo, Francesca Schillani, Alessandro Tossi
Publikováno v:
ARKIVOC, Vol 2003, Iss 14, Pp 140-154 (2003)
Externí odkaz:
https://doaj.org/article/6b916ce6dbc94814ab9fa5898ca250c5
Publikováno v:
Life, Vol 14, Iss 2, p 230 (2024)
This review aims to provide a comprehensive overview of the application of bacterial and fungal laccases for the removal of pharmaceuticals from the environment. Laccases were evaluated for their efficacy in degrading pharmaceutical substances across
Externí odkaz:
https://doaj.org/article/b8f6f2879cc943e98bfc5bafc881b025
Publikováno v:
Fermentation, Vol 8, Iss 9, p 451 (2022)
The accumulation of polyhydroxyalkanoates (PHAs) by microorganisms usually occurs in response to environmental stress conditions. Therefore, it is advantageous to choose two-step cultivation. The first phase is aimed at maximizing biomass production,
Externí odkaz:
https://doaj.org/article/5dac9b1e933742b4b6e9b1e46b5d9e7b
Autor:
Sabina Lipničanová, Barbora Legerská, Daniela Chmelová, Miroslav Ondrejovič, Stanislav Miertuš
Publikováno v:
Biomolecules, Vol 12, Iss 2, p 331 (2022)
Neuraminidase (NA), as an important protein of influenza virus, represents a promising target for the development of new antiviral agents for the treatment and prevention of influenza A and B. Bacterial host strain Escherichia coli BL21 (DE3)pLysS co
Externí odkaz:
https://doaj.org/article/a49593c09041477d8c60237e697ae783
Publikováno v:
Fermentation, Vol 8, Iss 1, p 16 (2021)
Polyhydroxyalkanoates (PHAs) represent a promising alternative to commercially used petroleum-based plastics. Pseudomonas oleovorans is a natural producer of medium-chain-length PHA (mcl-PHA) under cultivation conditions with nitrogen limitation and
Externí odkaz:
https://doaj.org/article/608a0259afd94a55b44f7f52f2bd19fd
Publikováno v:
World Journal of Microbiology and Biotechnology. 38
Laccases (E.C. 1.10.3.2) produced by white-rot fungi (WRF) can be widely used, but the high cost prevents their use in large-scale industrial processes. Finding a solution to the problem could involve laccase production by solid-state fermentation (S
Autor:
Sabina, Lipničanová, Barbora, Legerská, Daniela, Chmelová, Miroslav, Ondrejovič, Stanislav, Miertuš
Publikováno v:
Biomolecules. 12(2)
Neuraminidase (NA), as an important protein of influenza virus, represents a promising target for the development of new antiviral agents for the treatment and prevention of influenza A and B. Bacterial host strain