Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Stanislav Kadlcik"'
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-4 (2018)
Externí odkaz:
https://doaj.org/article/2d0137298e4a4257983427c1680430d6
Evolution-guided adaptation of an adenylation domain substrate specificity to an unusual amino acid.
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189684 (2017)
Adenylation domains CcbC and LmbC control the specific incorporation of amino acid precursors in the biosynthesis of lincosamide antibiotics celesticetin and lincomycin. Both proteins originate from a common L-proline-specific ancestor, but LmbC was
Externí odkaz:
https://doaj.org/article/11be6398b0a84195a68b6b07faf9e07f
Autor:
Jiri Janata, Stanislav Kadlcik, Marketa Koberska, Dana Ulanova, Zdenek Kamenik, Petr Novak, Jan Kopecky, Jitka Novotna, Bojana Radojevic, Kamila Plhackova, Radek Gazak, Lucie Najmanova
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0118850 (2015)
In the biosynthesis of lincosamide antibiotics lincomycin and celesticetin, the amino acid and amino sugar units are linked by an amide bond. The respective condensing enzyme lincosamide synthetase (LS) is expected to be an unusual system combining n
Externí odkaz:
https://doaj.org/article/cc4e1957a3dd4e7fa19dfb1f2dacdc28
Publikováno v:
Angewandte Chemie International Edition.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39aea1f3409b59bbbd29923c012a91de
https://doi.org/10.1002/anie.202304989
https://doi.org/10.1002/anie.202304989
Autor:
Jiri Janata, Ghader Bashiri, Stanislav Kadlcik, Radek Gazak, Marek Kuzma, Petr Man, Lucie Steiningerova, Magdalena Pavlikova, Zdenek Kamenik
Publikováno v:
Journal of the American Chemical Society. 142:3440-3448
Antitumor pyrrolobenzodiazepines (PBDs), lincosamide antibiotics, quorum-sensing molecule hormaomycin, and antimicrobial griselimycin are structurally and functionally diverse groups of actinobacterial metabolites. The common feature of these compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe16eebe17c1725813c9586877d131a9
https://doi.org/10.1021/jacs.9b11234
https://doi.org/10.1021/jacs.9b11234
Publikováno v:
Microbiological Research. 265:127186
Here we provide a review on TldD/TldE family proteins, summarizing current knowledge and outlining further research perspectives. Despite being widely distributed in bacteria and archaea, TldD/TldE proteins have been escaping attention for a long tim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7ac621ebb720a3a455877bbdd33aa3d
https://doi.org/10.1016/j.micres.2022.127186
https://doi.org/10.1016/j.micres.2022.127186
Autor:
Lucie, Steiningerova, Zdenek, Kamenik, Radek, Gazak, Stanislav, Kadlcik, Ghader, Bashiri, Petr, Man, Marek, Kuzma, Magdalena, Pavlikova, Jiri, Janata
Publikováno v:
Journal of the American Chemical Society. 142(7)
Antitumor pyrrolobenzodiazepines (PBDs), lincosamide antibiotics, quorum-sensing molecule hormaomycin, and antimicrobial griselimycin are structurally and functionally diverse groups of actinobacterial metabolites. The common feature of these compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5e32b9193a38134aa503258b078f71fa
https://pubmed.ncbi.nlm.nih.gov/31944685
https://pubmed.ncbi.nlm.nih.gov/31944685
Autor:
Marek Kuzma, Stanislav Kadlcik, Jiri Janata, Zdenek Kamenik, Lucie Najmanova, Magdalena Pavlikova
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports
Scientific Reports
Natural pyrrolobenzodiazepines (PBDs) form a large and structurally diverse group of antitumour microbial metabolites produced through complex pathways, which are encoded within biosynthetic gene clusters. We sequenced the gene cluster of limazepines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9787db418da96725987aacd88396533
http://link.springer.com/article/10.1038/s41598-018-26179-w
http://link.springer.com/article/10.1038/s41598-018-26179-w
Autor:
Lucie Najmanova, Jiri Janata, Marek Kuzma, Jan Kopecky, Bojana Radojevic, Zdenek Kamenik, Radek Gazak, Petra Jiraskova, Stanislav Kadlcik
Publikováno v:
Chemical Science. 7:430-435
The immediate post-condensation steps in lincomycin biosynthesis are reminiscent of the mycothiol-dependent detoxification system of actinomycetes. This machinery provides the last proven lincomycin intermediate, a mercapturic acid derivative, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c965e029e6f09f84394efb6d407870d
https://doi.org/10.1039/c5sc03327f
https://doi.org/10.1039/c5sc03327f
Publikováno v:
Natural product reports. 35(3)
Covering: up to 2017 This review covers the biosynthetic and evolutionary aspects of lincosamide antibiotics, antitumour pyrrolobenzodiazepines (PBDs) and the quorum-sensing molecule hormaomycin. These structurally and functionally diverse groups of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a167e67e9a086f37bc5214ab05e6c8e
https://pubmed.ncbi.nlm.nih.gov/29517100
https://pubmed.ncbi.nlm.nih.gov/29517100