Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Stanislav A. Bakunov"'
In Vitro and In Vivo Biological Effects of Novel Arylimidamide Derivatives against Trypanosoma cruzi
Autor:
Maria de Nazaré Correia Soeiro, Bruno Lisboa Timm, Donald A. Patrick, Francisca Hildemagna Guedes da Silva, Susan Jones, Stanislav A. Bakunov, Marcos Meuser Batista, Svetlana M. Bakunova, Richard R. Tidwell, Cristiane França da Silva, Patrícia Bernardino da Silva
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:3720-3726
Chagas disease (CD), a neglected tropical disease caused by Trypanosoma cruzi , remains a serious public health problem in several Latin American countries. The available chemotherapies for CD have limited efficacy and exhibit undesirable side effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea493f5d8b9618b2a289d8896678774b
https://doi.org/10.1128/aac.02353-14
https://doi.org/10.1128/aac.02353-14
Autor:
Stanislav A. Bakunov, Richard R. Tidwell, Svetlana M. Bakunova, Reto Brun, Tanja Wenzler, Donald A. Patrick
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:559-576
Fifty novel prodrugs and aza-analogues of 3,5-bis(4-amidinophenyl)isoxazole and its derivatives were prepared. Eighteen of the 24 aza-analogues exhibited IC₅₀ values below 25 nM against Trypanosoma brucei rhodesiense or Plasmodium falciparum. Six
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817fa38452c2a54dc2703ae2ad579b0d
https://doi.org/10.1016/j.bmc.2013.10.050
https://doi.org/10.1016/j.bmc.2013.10.050
Autor:
Donald A. Patrick, R R Tidwell, Maria de Nazaré Correia Soeiro, Otacilio C. Moreira, C. F. Da Silva, P. B. Da Silva, Kelly Cristina Demarque, Svetlana M. Bakunova, Constança Britto, Stanislav A. Bakunov, T. O. Fulco, Julianna Siciliano de Araújo, F. H. Guedes-da-Silva, Gilkethyla Mexlayne de Oliveira, D. G. J. Batista, M. B. Meuser
Arylimidamides (AIAs) have been shown to have considerable biological activity against intracellular pathogens, including Trypanosoma cruzi , which causes Chagas disease. In the present study, the activities of 12 novel bis-AIAs and 2 mono-AIAs again
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9931d7933fdd07aea27acf8c429ef9b4
https://europepmc.org/articles/PMC4808220/
https://europepmc.org/articles/PMC4808220/
Autor:
Arlene S. Bridges, E. V. K. Suresh Kumar, Reto Brun, Stanislav A. Bakunov, Karl A. Werbovetz, Susan Jones, Donald A. Patrick, Kwasi A. Ohemeng, Todd Barszcz, Richard R. Tidwell, Tanja Wenzler, Svetlana M. Bakunova
Publikováno v:
Journal of Medicinal Chemistry. 52:2016-2035
Diamidine 1 (pentamidine) and 65 analogues (2-66) have been tested for in vitro antiprotozoal activities against Trypanosoma brucei rhodesiense, Plasmodium falciparum, and Leishmania donovani, and for cytotoxicity against mammalian cells. Dications 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89523a3ac4b43ffb24c86222c35eefb5
https://doi.org/10.1021/jm801547t
https://doi.org/10.1021/jm801547t
Autor:
Karl A. Werbovetz, Reto Brun, Todd Barszcz, Svetlana M. Bakunova, Stanislav A. Bakunov, Richard R. Tidwell, Tanja Wenzler
Publikováno v:
Journal of Medicinal Chemistry. 51:6927-6944
A series of cationically substituted 2-phenylbenzofurans 1- 49 have been synthesized, and their in vitro antiprotozoal properties against Trypanosoma brucei rhodesiense, Plasmodium falciparum, and Leishmania donovani, as well as cytotoxicity against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f15a5851bb9cc896f5c0406c71454f83
https://doi.org/10.1021/jm800918v
https://doi.org/10.1021/jm800918v
Autor:
Tanja Wenzler, James Edwin Hall, Svetlana M. Bakunova, Stanislav A. Bakunov, Reto Brun, Karl A. Werbovetz, Richard R. Tidwell, Todd Barszcz
Publikováno v:
Journal of Medicinal Chemistry. 50:5807-5823
Forty three cationic bisbenzofurans were synthesized either by interaction of o-hydroxyaldehydes with alpha-halogenated ketones followed by intramolecular ring closure or by a copper- or palladium-mediated heteroannulation of substituted o-iodophenol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b0c97a21f8bdda72ebfdd4ab56eb28
https://doi.org/10.1021/jm0708634
https://doi.org/10.1021/jm0708634
Autor:
Svetlana M. Bakunova, Arlene S. Bridges, Richard R. Tidwell, Donald A. Patrick, Susan Jones, E. V. K. Suresh Kumar, James Edwin Hall, Tanja Wenzler, Reto Brun, Richard J. Lombardy, Stanislav A. Bakunov, Oksana Zhirnov
Publikováno v:
Journal of Medicinal Chemistry. 50:2468-2485
3,5-bis(4-amidinophenyl)isoxazole (3)-an analogue of 2,5-bis(4-amidinophenyl)furan (furamidine) in which the central furan ring is replaced by isoxazole-and 42 novel analogues were prepared by two general synthetic pathways. The 43 isoxazole derivati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a3f04b636d87c93558808d435546fdf
https://doi.org/10.1021/jm0612867
https://doi.org/10.1021/jm0612867
Publikováno v:
Synthesis. 2000:1148-1159
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c93931f316af412bac2493697d56b8b7
https://doi.org/10.1055/s-2000-6317
https://doi.org/10.1055/s-2000-6317
Autor:
Todd Barszcz, David W. Boykin, Susan Jones, Arvind Kumar, Svetlana M. Bakunova, Karl A. Werbovetz, Stanislav A. Bakunov, Donald A. Patrick, Richard R. Tidwell, Tanja Wenzler, Reto Brun
Publikováno v:
European journal of medicinal chemistry. 67
Sixty-two cationic benzyl phenyl ether derivatives (36 amidines and 26 prodrugs) were prepared and assayed for activities in vitro and in vivo against Trypanosoma brucei rhodesiense (STIB900), and in vitro against Plasmodium falciparum (K1) and Leish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::006a5d74b407e8863ac5c6dc8ae2e33b
https://pubmed.ncbi.nlm.nih.gov/23871911
https://pubmed.ncbi.nlm.nih.gov/23871911
Publikováno v:
Tetrahedron. 51:8565-8572
Structure of α-hydroxyl amino oxime derived from monoterpene hydrocarbon limonene was carefully determined using NMR technique and confirmed by chemical transformations. This α-hydroxyl amino oxime derivative of limonene, that was believed to be a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90a34abe87ac8da815c3e4f0b33564e5
https://doi.org/10.1016/0040-4020(95)00471-j
https://doi.org/10.1016/0040-4020(95)00471-j