Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Stanislav, Vukmanović"'
Publikováno v:
Nature. 359:729-732
T lymphocytes recognize antigens as peptide fragments associated with molecules encoded by the major histocompatibility complex (MHC) and expressed on the surface of antigen-presenting cells. In the thymus, T cells bearing alpha beta receptors that r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad093fdae9ad76f34d068c0331d8c2d5
https://doi.org/10.1038/359729a0
https://doi.org/10.1038/359729a0
Publikováno v:
Immunogenetics. 55(11)
MHC class I molecules are heterotrimeric complexes composed of heavy chain, beta2-microglobulin (beta2m) and short peptide. This trimeric complex is generated in the endoplasmic reticulum (ER), where a peptide loading complex (PLC) facilitates transp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::64a207e664d018902a713724eadd5011
https://pubmed.ncbi.nlm.nih.gov/14735325
https://pubmed.ncbi.nlm.nih.gov/14735325
Publikováno v:
Immunological reviews. 190
Self-peptide/major histocompatibility complex (MHC) complexes profoundly influence the biology of T lymphocytes. They promote the selection of the T cell receptor (TCR) repertoire in the thymus, maintain the homeostasis of peripheral T cells prior to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::07762e7f3d735a129fe779c4e639b30d
https://pubmed.ncbi.nlm.nih.gov/12493012
https://pubmed.ncbi.nlm.nih.gov/12493012
Publikováno v:
Transplantation. 73(5)
Strong alloreactive T cell responses are a menace in transplantation surgery and their menagement requires understanding the basis of alloreactivity. Alloantigen recognition can be peptide independent, peptide specific, or peptide dependent. The mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d8f83129700e14c471a1f43bac6bc18e
https://pubmed.ncbi.nlm.nih.gov/11907430
https://pubmed.ncbi.nlm.nih.gov/11907430
Autor:
Ivica Arsov, Stanislav Vukmanović
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 162(4)
In the final stages of thymic development, immature T cells undergo three distinct processes (positive selection, negative selection, and lineage commitment) that all depend on interactions of thymocyte TCRs with MHC molecules. It is currently though
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d485848a41ea0d2798e180f16a346d4c
https://pubmed.ncbi.nlm.nih.gov/9973472
https://pubmed.ncbi.nlm.nih.gov/9973472
Publikováno v:
International immunology. 6(2)
TCR engagement in the thymus results in both survival and elimination signals for developing thymocytes. To examine whether both signals can be provided by the same cell type, we investigated the ability of a thymic epithelial cell (TEC) line 427.1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec6b5e5258153f3f146c8d8aeb781f1e
https://pubmed.ncbi.nlm.nih.gov/8155600
https://pubmed.ncbi.nlm.nih.gov/8155600
Publikováno v:
The Journal of Immunology. 169:4674-4674
Allelic exclusion is inefficient at the TCRα locus, allowing a sizeable portion of T cells to carry two functional TCRs. The potential danger of dual TCR expression is a rescue of autoreactive TCRs during selection in the thymus and subsequent devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e651fe226821c0d5450f66e4432d09c
https://doi.org/10.4049/jimmunol.169.8.4674
https://doi.org/10.4049/jimmunol.169.8.4674