Zobrazeno 1 - 10
of 458
pro vyhledávání: '"Stanislav, Gobec"'
Autor:
Levente Kollár, Katarina Grabrijan, Martina Hrast Rambaher, Krištof Bozovičar, Tímea Imre, György G. Ferenczy, Stanislav Gobec, György M. Keserű
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractPenicillin-binding proteins (PBPs) contribute to bacterial cell wall biosynthesis and are targets of antibacterial agents. Here, we investigated PBP1b inhibition by boronic acid derivatives. Chemical starting points were identified by structu
Externí odkaz:
https://doaj.org/article/3aa73b81e4b544ed9ddec929dc30123d
Autor:
Luka Rejc, Damijan Knez, Gabriela Molina-Aguirre, Alba Espargaró, Jerneja Kladnik, Anže Meden, Lana Blinc, Matic Lozinšek, Ross D. Jansen-van Vuuren, Matic Rogan, Bruno Aleksander Martek, Jernej Mlakar, Ana Dremelj, Andrej Petrič, Stanislav Gobec, Raimon Sabaté, Mara Bresjanac, Balazs Pinter, Janez Košmrlj
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116616- (2024)
Fluorescent probes are a powerful tool for imaging amyloid β (Aβ) plaques, the hallmark of Alzheimer’s disease (AD). Herein, we report the synthesis and comprehensive characterization of 21 novel probes as well as their optical properties and bin
Externí odkaz:
https://doaj.org/article/5dba3452cc3d4596945a7835ff379451
Autor:
Nika Strašek Benedik, Ana Dolšak, Urban Švajger, Izidor Sosič, Stanislav Gobec, Matej Sova
Publikováno v:
ACS Omega, Vol 9, Iss 2, Pp 2362-2382 (2024)
Externí odkaz:
https://doaj.org/article/ef98ac5266814f379741038d4cb19056
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1, Pp 387-397 (2023)
Bacterial resistance is an increasing threat to healthcare systems, highlighting the need for discovering new antibacterial agents. An established technique, fragment-based drug discovery, was used to target a bacterial enzyme Ddl involved in the bio
Externí odkaz:
https://doaj.org/article/ed3c6b42930745d2a6bd5cc66b4d848a
Publikováno v:
ACS Omega, Vol 8, Iss 36, Pp 33006-33016 (2023)
Externí odkaz:
https://doaj.org/article/b66abc5b3bbe41ed94f949a1d5f84037
Autor:
Damijan Knez, Daniel Diez-Iriepa, Mourad Chioua, Andrea Gottinger, Milica Denic, Fabien Chantegreil, Florian Nachon, Xavier Brazzolotto, Anna Skrzypczak-Wiercioch, Anže Meden, Anja Pišlar, Janko Kos, Simon Žakelj, Jure Stojan, Kinga Sałat, Julia Serrano, Ana Patricia Fernández, Aitana Sánchez-García, Ricardo Martínez-Murillo, Claudia Binda, Francisco López-Muñoz, Stanislav Gobec, José Marco-Contelles
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 5, Pp 2152-2175 (2023)
We describe the development of quinolylnitrones (QNs) as multifunctional ligands inhibiting cholinesterases (ChEs: acetylcholinesterase and butyrylcholinesterase–hBChE) and monoamine oxidases (hMAO-A/B) for the therapy of neurodegenerative diseases
Externí odkaz:
https://doaj.org/article/7f16c8ed45a64b12942b299889a26612
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 5420-5429 (2022)
For the development of concentrated monoclonal antibody formulations for subcutaneous administration, the main challenge is the high viscosity of the solutions. To compensate for this, viscosity reducing agents are commonly used as excipients. Here,
Externí odkaz:
https://doaj.org/article/a635c0e9d2914fa29fff68bb75575823
Autor:
Ana Mitrović, Emanuela Senjor, Marko Jukić, Lara Bolčina, Mateja Prunk, Matic Proj, Milica Perišić Nanut, Stanislav Gobec, Janko Kos
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 4667-4687 (2022)
Cathepsin V is a human lysosomal cysteine peptidase with specific functions during pathological processes and is as such a promising therapeutic target. Peptidase inhibitors represent powerful pharmacological tools for regulating excessive proteolyti
Externí odkaz:
https://doaj.org/article/4a44fe59f8b842328973cf7efc4be90a
Autor:
Marko Jukič, Rodolphe Auger, Victor Folcher, Matic Proj, Hélène Barreteau, Stanislav Gobec, Thierry Touzé
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 2360-2371 (2022)
Increasing resistance to common antibiotics is becoming a major challenge that requires the development of new antibacterial agents. Peptidoglycan is an essential heteropolymer of the bacterial envelope that ensures the integrity and shape of all bac
Externí odkaz:
https://doaj.org/article/c46b1d1a607541adb2ed8da2b9d1a317
Autor:
Maja Zakošek Pipan, Sonja Prpar Mihevc, Malan Štrbenc, Urban Košak, Ilija German Ilić, Jurij Trontelj, Simon Žakelj, Stanislav Gobec, Darja Pavlin, Gregor Majdič
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Canine cognitive dysfunction (CCD) is common in aged dogs and has many similarities with Alzheimer’s disease. Unfortunately, like Alzheimer’s disease, CCD cannot be cured. In the present study, we treated dogs with CCD with our newly dev
Externí odkaz:
https://doaj.org/article/32c976e38cff4eb89133a4590bc3ef91