Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Stanislav, Beyl"'
Autor:
Bozhidar Baltov, Stanislav Beyl, Igor Baburin, Jakob Reinhardt, Phillip Szkokan, Aleksandra Garifulina, Eugen Timin, Udo Kraushaar, Olivier Potterat, Matthias Hamburger, Philipp Kügler, Steffen Hering
Publikováno v:
Toxicology Reports, Vol 10, Iss , Pp 589-599 (2023)
Guidelines for preclinical drug development reduce the occurrence of arrhythmia-related side effects. Besides ample evidence for the presence of arrhythmogenic substances in plants, there is no consensus on a research strategy for the evaluation of p
Externí odkaz:
https://doaj.org/article/fda309defa0a4cfd8025cc81e3d736a8
Autor:
Marco Thurner, Martin Deutsch, Katrin Janke, Franka Messner, Christina Kreutzer, Stanislav Beyl, Sébastien Couillard-Després, Steffen Hering, Jakob Troppmair, Rainer Marksteiner
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-17 (2020)
Abstract Background Degeneration of smooth muscles in sphincters can cause debilitating diseases such as fecal incontinence. Skeletal muscle-derived cells have been effectively used in clinics for the regeneration of the skeletal muscle sphincters, s
Externí odkaz:
https://doaj.org/article/dcc1b4dfa47d4f77bf9bbcc837b7b261
Autor:
Martin Deutsch, Christina Kreutzer, Marco Thurner, Katrin Janke, Sebastien Couillard-Despres, Steffen Hering, Jakob Troppmair, Franka Messner, Stanislav Beyl, Rainer Marksteiner
Publikováno v:
Stem Cell Research & Therapy
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-17 (2020)
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-17 (2020)
Background Degeneration of smooth muscles in sphincters can cause debilitating diseases such as fecal incontinence. Skeletal muscle-derived cells have been effectively used in clinics for the regeneration of the skeletal muscle sphincters, such as th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9276755671a8de79cf5ace4115fd8fb5
https://doi.org/10.1186/s13287-020-01749-w
https://doi.org/10.1186/s13287-020-01749-w
Autor:
Eugen Timin, Stanislav Andranovits, Stanislav Beyl, Eva-Maria Zangerl-Plessl, Steffen Hering, Annette Hohaus
Publikováno v:
Pflugers Archiv
Tuned calcium entry through voltage-gated calcium channels is a key requirement for many cellular functions. This is ensured by channel gates which open during membrane depolarizations and seal the pore at rest. The gating process is determined by di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7007384e7a78b7c64766c5392adadf08
https://doi.org/10.1007/s00424-018-2163-7
https://doi.org/10.1007/s00424-018-2163-7
Autor:
Predrag Kalaba, Steffen Hering, Vladimir Dragačević, Eduardo René Pérez González, Marija Ilic, Philip John Neill, Jawad Akbar Khan, Tetyana Beryozkina, Karl Ebner, Nilima Y. Aher, Alexander Roller, Martin Zehl, Johann Leban, Thierry Langer, Simone B. Sartori, Harald H. Sitte, Marcus Wieder, Gert Lubec, Natalie Lukic, Christian Pifl, Nicolas Singewald, Jana Lubec, Stanislav Beyl, Vasiliy A. Bakulev, Judith Wackerlig, Ernst Urban
Publikováno v:
Journal of medicinal chemistry. 63(1)
Atypical dopamine reuptake inhibitors, such as modafinil, are used for the treatment of sleeping disorders and investigated as potential therapeutics against cocaine addiction and for cognitive enhancement. Our continuous effort to find modafinil ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79bce31f07f75eed1e9e8b5a07a6c8f8
https://pubmed.ncbi.nlm.nih.gov/31841637
https://pubmed.ncbi.nlm.nih.gov/31841637
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 468:1895-1907
In order to specify the role of individual S4 segments in CaV1.2 gating, charged residues of segments IS4-IVS4 were replaced by glutamine and the corresponding effects on activation/deactivation of calcium channel currents were analysed. Almost all r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16075a30b6dffeb41cce53176e793c8f
https://doi.org/10.1007/s00424-016-1895-5
https://doi.org/10.1007/s00424-016-1895-5
Autor:
Muge, Qile, Henriette D M, Beekman, David J, Sprenkeler, Marien J C, Houtman, Willem B, van Ham, Anna, Stary-Weinzinger, Stanislav, Beyl, Steffen, Hering, Dirk-Jan, van den Berg, Elizabeth C M, de Lange, Laura H, Heitman, Ad P, IJzerman, Marc A, Vos, Marcel A G, van der Heyden
Publikováno v:
British Journal of Pharmacology
Background and Purpose Kv11.1 (hERG) channel blockade is an adverse effect of many drugs and lead compounds, associated with lethal cardiac arrhythmias. LUF7244 is a negative allosteric modulator/activator of Kv11.1 channels that inhibits early after
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::66ac4c668312463df84314187799a0a6
https://pubmed.ncbi.nlm.nih.gov/31339551
https://pubmed.ncbi.nlm.nih.gov/31339551
Autor:
Igor, Baburin, Rosanne, Varkevisser, Anja, Schramm, Priyanka, Saxena, Stanislav, Beyl, Phillip, Szkokan, Tobias, Linder, Anna, Stary-Weinzinger, Marcel A G, van der Heyden, Marien, Houtman, Hiroki, Takanari, Malin, Jonsson, Jet H D, Beekman, Matthias, Hamburger, Marc A, Vos, Steffen, Hering
Publikováno v:
Pharmacological research. 131
Evodiae fructus is a widely used herbal drug in traditional Chinese medicine. Evodia extract was found to inhibit hERG channels. The aim of the current study was to identify hERG inhibitors in Evodia extract and to investigate their potential proarrh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a3a0e30d8137616ab18c26a4831a1c5f
https://pubmed.ncbi.nlm.nih.gov/29477480
https://pubmed.ncbi.nlm.nih.gov/29477480
Autor:
Steffen Hering, Annette Hohaus, Stanislav Andranovits, Stanislav Beyl, Eva-Maria Zangerl-Plessl, Eugen Timin
Publikováno v:
Pflugers Archiv
Inactivation of L-type calcium channel (Cav1.2) is an important determinant of the length of the cardiac action potential. Here, we report a key role of the voltage-sensing segment IS4 in Cav1.2 inactivation. Neutralization of IS4 charges gradually s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41587ba4683132ea1064c520cdbd16e9
https://doi.org/10.1007/s00424-017-2038-3
https://doi.org/10.1007/s00424-017-2038-3
Autor:
Marien J C Houtman, Laura H. Heitman, Marc A. Vos, Elizabeth C. M. de Lange, Stanislav Beyl, Ad P. IJzerman, Steffen Hering, David J Sprenkeler, Muge Qile, Willem B. van Ham, Marcel A.G. van der Heyden, Henriette D.M. Beekman, Anna Stary-Weinzinger, Dirk-Jan van den Berg
Publikováno v:
British Journal of Pharmacology, 176(19), 3871-3885
British Journal of Pharmacology
British Journal of Pharmacology, 176(19), 3871. Wiley-Blackwell
British Journal of Pharmacology
British Journal of Pharmacology, 176(19), 3871. Wiley-Blackwell
Background and PurposeKv11.1 (hERG) channel blockade is an adverse effect of many drugs and lead compounds, associated with lethal cardiac arrhythmias. LUF7244 is a negative allosteric modulator/activator of Kv11.1 channels that inhibits early afterd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e979ff2166a7fb461226b7ed48c7dda
https://hdl.handle.net/1874/387119
https://hdl.handle.net/1874/387119