Gain-of-Function Mutations R249C and S250C in Complement C2 Protein Increase C3 Deposition in the Presence of C-Reactive Protein

Autor: Aleksandra Urban, Daria Kowalska, Grzegorz Stasiłojć, Alicja Kuźniewska, Anna Skrobińska, Emilia Arjona, Eugenia Castellote Alonso, María Ángeles Fenollosa Segarra, Ilse Jongerius, Robbert Spaapen, Simon Satchell, Marcel Thiel, Stanisław Ołdziej, Santiago Rodriguez de Córdoba, Marcin Okrój

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

The impairment of the alternative complement pathway contributes to rare kidney diseases such as atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G). We recently described an aHUS patient carrying an exceptional gain-of-function (Go

Externí odkaz: https://doaj.org/article/717a2faa64dc496784006a113f6cb136

Modeling the Structure, Dynamics, and Transformations of Proteins with the UNRES Force Field

Autor: Adam K, Sieradzan, Cezary, Czaplewski, Paweł, Krupa, Magdalena A, Mozolewska, Agnieszka S, Karczyńska, Agnieszka G, Lipska, Emilia A, Lubecka, Ewa, Gołaś, Tomasz, Wirecki, Mariusz, Makowski, Stanisław, Ołdziej, Adam, Liwo

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2376

The physics-based united-residue (UNRES) model of proteins ( www.unres.pl ) has been designed to carry out large-scale simulations of protein folding. The force field has been derived and parameterized based on the principles of statistical-mechanics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::12e1cd6159f6746e938f016a8488aac0
https://pubmed.ncbi.nlm.nih.gov/34845623

Gain-of-function mutation in complement C2 protein identified in a patient with aHUS

Autor: Anna M. Blom, Stanisław Ołdziej, Ilse Jongerius, Grzegorz Stasiłojć, Emilia Arjona, Aleksandra Urban, Anna Felberg, Elena B. Volokhina, Marcin Okroj, Marcel Thiel, Santiago Rodríguez de Córdoba, Lambertus P. van den Heuvel

Publikováno v: Journal of Allergy and Clinical Immunology, 146, 916-919.e11
Journal of Allergy and Clinical Immunology, 146, 4, pp. 916-919.e11
Digital.CSIC. Repositorio Institucional del CSIC
instname
Journal of allergy and clinical immunology, 146(4), 916-919.e11. Mosby Inc.

15 p.-1 fig.-1 tab.-7 fig. supl.
Supported by National Science Centre Poland (grant 2015/18/M/NZ6/00334), Ministerio de Economía y Competitividad/FEDER (grant SAF2015-66287-R), and Autonomous Region of Madrid (grant S2017/BMD-3673).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::705c87267eaba98950440a31e52be785
https://lirias.kuleuven.be/handle/123456789/670591

Maximum Likelihood Calibration of the UNRES Force Field for Simulation of Protein Structure and Dynamics

Autor: Anna Hałabis, Adam Liwo, Stanisław Ołdziej, Wioletta Żmudzińska, Harold A. Scheraga, Paweł Krupa

Publikováno v: Journal of Chemical Information and Modeling. 57:2364-2377

By using the maximum likelihood method for force-field calibration recently developed in our laboratory, which is aimed at achieving the agreement between the simulated conformational ensembles of selected training proteins and the corresponding ense

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9188a589718a9710ba8f676c350361ed
https://doi.org/10.1021/acs.jcim.7b00254

MOLECULAR SIMULATIONS WITH HIGH-PERFORMANCE COMPUTERS

Autor: PIOTR ARŁUKOWICZ, EWA BIERNAT, JERZY CIARKOWSKI, CEZARY CZAPLEWSKI, MAŁGORZATA GROTH, RAJMUND KAŹMIERKIEWICZ, ADAM LIWO, KATARZYNA MAKSIMIAK, MAŁGORZATA NOWACKA, STANISŁAW OŁDZIEJ, SYLWIA RODZIEWICZ, EDYTA WOŹNIAK

Publikováno v: TASK Quarterly, Vol 1, Iss 1 (1997)

In this article, we present the work carried out in our group on various fields of theoretical biochemistry. Our main fields of research are as follows: i) design of an algorithm fordc novo prediction of protein structure from amino-acid sequence usi

Externí odkaz: https://doaj.org/article/3e21ba25314545ffbbcf3602b2bb1e89