Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators.

Autor: Henderson AR; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109.; Program in Chemical Biology, University of Michigan, Ann Arbor, MI 48109., Henley MJ; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109.; Program in Chemical Biology, University of Michigan, Ann Arbor, MI 48109., Foster NJ; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109.; Program in Chemical Biology, University of Michigan, Ann Arbor, MI 48109., Peiffer AL; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109.; Program in Chemical Biology, University of Michigan, Ann Arbor, MI 48109., Beyersdorf MS; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109.; Program in Chemical Biology, University of Michigan, Ann Arbor, MI 48109., Stanford KD; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109.; Department of Chemistry, University of Michigan, Ann Arbor, MI 48109., Sturlis SM; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109., Linhares BM; Department of Biophysics, University of Michigan, Ann Arbor, MI 48109., Hill ZB; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158., Wells JA; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158., Cierpicki T; Program in Chemical Biology, University of Michigan, Ann Arbor, MI 48109.; Department of Biophysics, University of Michigan, Ann Arbor, MI 48109., Brooks CL 3rd; Program in Chemical Biology, University of Michigan, Ann Arbor, MI 48109.; Department of Chemistry, University of Michigan, Ann Arbor, MI 48109.; Department of Biophysics, University of Michigan, Ann Arbor, MI 48109., Fierke CA; Program in Chemical Biology, University of Michigan, Ann Arbor, MI 48109.; Department of Chemistry, University of Michigan, Ann Arbor, MI 48109., Mapp AK; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109; amapp@umich.edu.; Program in Chemical Biology, University of Michigan, Ann Arbor, MI 48109.; Department of Chemistry, University of Michigan, Ann Arbor, MI 48109.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Sep 04; Vol. 115 (36), pp. 8960-8965. Date of Electronic Publication: 2018 Aug 20.