Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Stane Pajk"'
Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes
Autor:
Stane Pajk, Damijan Knez, Urban Košak, Maja Zorović, Xavier Brazzolotto, Nicolas Coquelle, Florian Nachon, Jacques-Philippe Colletier, Marko Živin, Jure Stojan, Stanislav Gobec
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 498-505 (2020)
Brain butyrylcholinesterase (BChE) is an attractive target for drugs designed for the treatment of Alzheimer’s disease (AD) in its advanced stages. It also potentially represents a biomarker for progression of this disease. Based on the crystal str
Externí odkaz:
https://doaj.org/article/dbf12d5fe8ba43da9d6b77ed1a105af9
Publikováno v:
Acta Chimica Slovenica, Vol 66, Iss 4, Pp 934-943 (2019)
Polysorbates (PS) are the most common non-ionic surfactants used in protein formulations. Their degradation has been studied intensively in recent years. Ester bond hydrolysis is one of many pathways of PS degradation that can lead to accumulation of
Externí odkaz:
https://doaj.org/article/8a490486103746379735e7bbf518ad74
Publikováno v:
Acta Chimica Slovenica, Vol 66, Iss 3, Pp 668-674 (2019)
Biological functions of cell membranes and their correlation to the heterogeneity of the latter’s lipid composition are still poorly understood. Fluorescence provides one of the most versatile tools for studying biological membranes. However, few b
Externí odkaz:
https://doaj.org/article/08de634b8ba74fe2b9f5e1ca4d050989
Publikováno v:
Pharmaceutics, Vol 14, Iss 2, p 325 (2022)
Oxidation is the second most common degradation pathway for pharmaceuticals, after hydrolysis. However, in contrast to hydrolysis, oxidation is mechanistically more complex and produces a wider range of degradation products; oxidation is thus harder
Externí odkaz:
https://doaj.org/article/e7b2f0e346be418380e2ceb4f209e303
Autor:
Tihomir Tomašič, Asta Zubrienė, Žiga Skok, Riccardo Martini, Stane Pajk, Izidor Sosič, Janez Ilaš, Daumantas Matulis, Sharon D. Bryant
Publikováno v:
Pharmaceuticals, Vol 14, Iss 8, p 789 (2021)
DNA gyrase is an important target for the development of novel antibiotics. Although ATP-competitive DNA gyrase (GyrB) inhibitors are a well-studied class of antibacterial agents, there is currently no representative used in therapy, largely due to u
Externí odkaz:
https://doaj.org/article/ee00a302a11a4640be8c346b13958e36
Autor:
Elena Maria Loi, Matjaž Weiss, Stane Pajk, Martina Gobec, Tihomir Tomašič, Roland J. Pieters, Marko Anderluh
Publikováno v:
Molecules, Vol 25, Iss 15, p 3381 (2020)
O-GlcNAcylation is an essential post-translational modification that occurs on nuclear and cytoplasmic proteins, regulating their function in response to cellular stress and altered nutrient availability. O-GlcNAc transferase (OGT) is the enzyme that
Externí odkaz:
https://doaj.org/article/56e7fb03ea994e22adf0d0f79bb2e463
Publikováno v:
Antioxidants, Vol 9, Iss 5, p 441 (2020)
Proteins are prone to post-translational modifications at specific sites, which can affect their physicochemical properties, and consequently also their safety and efficacy. Sources of post-translational modifications include oxygen and reactive oxyg
Externí odkaz:
https://doaj.org/article/eb2759a04cba4cb598696e043ff76788
Autor:
Črt Dragar, Tanja Potrč, Sebastjan Nemec, Robert Roškar, Stane Pajk, Petra Kocbek, Slavko Kralj
Publikováno v:
Materials, Vol 12, Iss 3, p 540 (2019)
The development of various magnetically-responsive nanostructures is of great importance in biomedicine. The controlled assembly of many small superparamagnetic nanocrystals into large multi-core clusters is needed for effective magnetic drug deliver
Externí odkaz:
https://doaj.org/article/bdfee15ca122408dae43d8b64b2e571e
Autor:
Joke Wuestenbergs, Wouter Van Den Bogaert, Stane Pajk, Michiel Vandenbosch, Wim Van de Voorde, Eva Cuypers
Publikováno v:
Journal of Analytical Toxicology, 46(7):095, 783-790. Preston Publications
Every year, thousands of suspicious deaths are accounted for by an overdose of opioids. Occasionally all traditional matrices are unavailable due to decomposition. Skeletal tissue may pose a valid alternative. However, reference data on postmortem co
Autor:
Anže Meden, Damijan Knez, Xavier Brazzolotto, Fabrice Modeste, Andrej Perdih, Anja Pišlar, Maša Zorman, Maja Zorović, Milica Denic, Stane Pajk, Marko Živin, Florian Nachon, Stanislav Gobec
Publikováno v:
European journal of medicinal chemistry. 247
Alongside reversible butyrylcholinesterase inhibitors, a plethora of covalent butyrylcholinesterase inhibitors have been reported in the literature, typically pseudo-irreversible carbamates. For these latter, however, most cases lack full confirmatio