Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Standwell Nkhoma"'
Autor:
Lisa J White, Jennifer A Flegg, Aung Pyae Phyo, Ja Hser Wiladpai-ngern, Delia Bethell, Christopher Plowe, Tim Anderson, Standwell Nkhoma, Shalini Nair, Rupam Tripura, Kasia Stepniewska, Wirichada Pan-Ngum, Kamolrat Silamut, Ben S Cooper, Yoel Lubell, Elizabeth A Ashley, Chea Nguon, François Nosten, Nicholas J White, Arjen M Dondorp
Publikováno v:
PLoS Medicine, Vol 12, Iss 4, p e1001823 (2015)
Artemisinin-resistant falciparum malaria has emerged in Southeast Asia, posing a major threat to malaria control. It is characterised by delayed asexual-stage parasite clearance, which is the reference comparator for the molecular marker 'Kelch 13' a
Externí odkaz:
https://doaj.org/article/5837c6b69e1446fa80f742dd88a04e89
Autor:
Marian C Bruce, Allan Macheso, Louise A Kelly-Hope, Standwell Nkhoma, Alex McConnachie, Malcolm E Molyneux
Publikováno v:
PLoS ONE, Vol 3, Iss 7, p e2775 (2008)
In malaria endemic regions people are commonly infected with multiple species of malaria parasites but the clinical impact of these Plasmodium co-infections is unclear. Differences in transmission seasonality and transmission intensity between endemi
Externí odkaz:
https://doaj.org/article/7d8726a5587c4eb68f165c1182accd36
Autor:
François Nosten, Thomas J. Peto, Douglas A. Shoue, Mehul Dhorda, Stefan H. I. Kappe, Elizabeth Delgado, Sudhir Kumar, Lisa A. Checkley, Ashley M. Vaughan, Meseret Haile, Ann N. Reyes, Katrina A. Button-Simons, Biley Abatiyow, Katelyn Vendrely Brenneman, Xue Li, Rupam Tripura, Tim J. Anderson, Ian H. Cheeseman, Dysoley Lek, Michael T. Ferdig, Standwell Nkhoma
Publikováno v:
iScience. 25:104095
BackgroundClassical genetic crosses in malaria parasites involve isolation, genotyping, and phenotyping of multiple progeny parasites, which is time consuming and laborious. Bulk segregant analysis (BSA) offers a powerful and efficient alternative to
Autor:
Tim J. Anderson, Shalini Nair, Xue Li, Ian H. Cheeseman, Marina McDew-White, Standwell Nkhoma
Publikováno v:
Genome Biology and Evolution
Microsatellite sequences are widely assumed to evolve neutrally, but also play an important role in bacterial pathogenesis, human disease and transcript abundance. The malaria parasitePlasmodium falciparumgenome is extraordinarily AT-rich, containing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7167fd23327a12efdec1bbe3ed80bd47
https://doi.org/10.1101/560516
https://doi.org/10.1101/560516
Autor:
Rose McGready, Nicholas J. White, Aung Pyae Phyo, Elizabeth A. Ashley, François Nosten, Tim J. Anderson, Fatma Bilgic, Marina McDew-White, Shalini Nair, Standwell Nkhoma, Ian H. Cheeseman
Publikováno v:
Molecular Biology and Evolution
Multiple kelch13 alleles conferring artemisinin resistance (ART-R) are currently spreading through Southeast Asian malaria parasite populations, providing a unique opportunity to observe an ongoing soft selective sweep, investigate why resistance all
Autor:
Standwell Nkhoma, Catherine Jett, Shalini Nair, Karla M. Gorena, Stephen A. Ward, Benjamin J. Daniel, Ian H. Cheeseman, Simon G. Trevino, Dianne J. Terlouw, Tim J. Anderson, Stanley Khoswe, Roy Garcia, Aliou Dia
Publikováno v:
Cell Host Microbe
Summary In high-transmission regions, we expect parasite lineages within complex malaria infections to be unrelated due to parasite inoculations from different mosquitoes. This project was designed to test this prediction. We generated 485 single-cel
Autor:
Roy Garcia, Simon G. Trevino, Stephen A. Ward, Catherine Jett, Benjamin J. Daniel, Standwell Nkhoma, Aliou Dia, Stanley Khoswe, Karla M. Gorena, Shalini Nair, Dianne J. Terlouw, Ian H. Cheeseman, Tim J. Anderson
Malaria patients can carry one or more clonal lineage of the parasite, Plasmodium falciparum, but the composition of these infections cannot be directly inferred from bulk sequence data. Well-defined, complete haplotypes at single-cell resolution are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::026a1cced1a64531a5f265ed4493ce3f
https://doi.org/10.1101/391268
https://doi.org/10.1101/391268
Autor:
Shalini Nair, Stephen A. Ward, Standwell Nkhoma, Ian H. Cheeseman, Simon G. Trevino, Tim J. Anderson, Karla M. Gorena, Dianne J. Terlouw, Catherine Jett, Aliou Dia, Stanley Khoswe, Roy Garcia, Benjamin J. Daniel
Publikováno v:
SSRN Electronic Journal.
Malaria patients can carry one or more clonal lineage of the parasite, Plasmodium falciparum. Well-defined, complete haplotypes at single-cell resolution are ideal for describing within-host population structure and unambiguously determining parasite
Autor:
Arjen M. Dondorp, Aung Pyae Phyo, Kasia Stepniewska, Khin Maung Lwin, Elizabeth A. Ashley, Nicholas J. White, François Nosten, Pratap Singhasivanon, Rose McGready, Tim J. Anderson, Carit Ler Moo, Nicholas P. J. Day, Salma Al-Saai, Standwell Nkhoma, Shalini Nair
Publikováno v:
Lancet
Summary Background Artemisinin-resistant falciparum malaria has arisen in western Cambodia. A concerted international effort is underway to contain artemisinin-resistant Plasmodium falciparum , but containment strategies are dependent on whether resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b1e8d582fb31a048449c02480dd30e
https://ora.ox.ac.uk/objects/uuid:8a22f17f-195a-4fbd-a174-962320a9250e
https://ora.ox.ac.uk/objects/uuid:8a22f17f-195a-4fbd-a174-962320a9250e
Autor:
Ian H. Cheeseman, Rachel Banda, François Nosten, Karla Moncada, Shalini Nair, Benjamin J. Daniel, Simon G. Trevino, Standwell Nkhoma, Stanley Khoswe
Publikováno v:
Genome Biology and Evolution
Single-cell genomics is a powerful tool for determining the genetic structure of complex communities of unicellular organisms. Patients infected with the malaria-causing parasite,Plasmodium falciparum, often carry multiple, genetically distinct paras