Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Stan Tsing"'
Autor:
Jennifer Fretland, Jeffrey Wu, Nidhi Arora, Fang‐Jie Zhang, Julie Q. Hang, Judy M. Suh, Stan Tsing, Seth F. Harris, Joshua Kennedy-Smith, Amber Paul, James Edward Paul Davidson, Sarah Sperry, J. Roland Billedeau, Mark D. Smith, Gabrielle Heilek, Klaus Klumpp, Guoping Su, Zachary Kevin Sweeney, Hassan Javanbakht, Amy S. Zhou, Taraneh Mirzadegan, Shelley K. Gleason, Yu Li, Ralf Roetz, Jesper A. Jernelius, Donald Roy Hirschfeld, Armando G. Villaseñor
Publikováno v:
Journal of Medicinal Chemistry. 51:7449-7458
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are recommended components of preferred combination antiretroviral therapies used for the treatment of HIV. These regimens are extremely effective in suppressing virus replication. Structure-ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c9dd621d2388ac4c08151f4728547da
https://doi.org/10.1021/jm800527x
https://doi.org/10.1021/jm800527x
Autor:
Jim W. Barnett, Andreas Kuglstatter, Kyung Song, Armando G. Villaseñor, Linghao Niu, Simon W. Lee, David E. Shaw, Stan Tsing, Michelle F. Browner
Publikováno v:
The Journal of Immunology. 178:2641-2645
IL-1R-associated kinase (IRAK)4 plays a central role in innate and adaptive immunity, and is a crucial component in IL-1/TLR signaling. We have determined the crystal structures of the apo and ligand-bound forms of human IRAK4 kinase domain. These st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fffe047704e2379c0394b880ca08635
https://doi.org/10.4049/jimmunol.178.5.2641
https://doi.org/10.4049/jimmunol.178.5.2641
Autor:
Elliott Sigal, Rebecca Mackenzie, Melody Chiou, Jose Freire, Joan Chow, Ramesha Chakk S, Dan Ives, Chinh Bach, Binh T. Nguyen, Hardy S. O. Chan, Stan Tsing, James P. Barnett, Eric Osen
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1209:130-139
Human prostaglandin G/H synthase 1 and 2 were expressed in the baculovims expression system and purified to high levels. Both enzymes were glycosylated. PGHS-1 appeared to be homogeneous by SDS-PAGE analysis but two closely migrating bands were detec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::521e0bc32c937b0e904783c852a12d3d
https://doi.org/10.1016/0167-4838(94)90148-1
https://doi.org/10.1016/0167-4838(94)90148-1
Autor:
Jim W. Barnett, Andreas Kuglstatter, J.M. Bradshaw, David E. Shaw, Simon W. Lee, Stan Tsing, Michelle F. Browner, April Wong, Armando G. Villaseñor, Y. Lou
Bruton's tyrosine kinase (BTK) plays a key role in B cell receptor signaling and is considered a promising drug target for lymphoma and inflammatory diseases. We have determined the X-ray crystal structures of BTK kinase domain in complex with six in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54040d9bae455a4ac65a9b88b0faba3a
https://europepmc.org/articles/PMC3048427/
https://europepmc.org/articles/PMC3048427/
Autor:
Manjiri Ghate, David E. Shaw, Armando G. Villaseñor, Stan Tsing, Jim W. Barnett, Michelle F. Browner, Andreas Kuglstatter
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(17)
JNK2 and p38alpha are closely related mitogen-activated protein kinases that regulate various cellular activities and are considered drug targets for inflammatory diseases. We have determined the X-ray crystal structure of the clinical phase II p38al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00bd6d9e4ee50dcbf5d8c5eda9853389
https://pubmed.ncbi.nlm.nih.gov/20655210
https://pubmed.ncbi.nlm.nih.gov/20655210
Autor:
Andreas Kuglstatter, Armando G. Villaseñor, Jim W. Barnett, David Walter, Stan Tsing, Michelle F. Browner, Sandra M. Wang, David E. Shaw
Publikováno v:
Journal of molecular biology. 383(4)
c-Jun N-terminal kinase (JNK) 2 is a member of the mitogen-activated protein (MAP) kinase group of signaling proteins. MAP kinases share a common sequence insertion called “MAP kinase insert”, which, for ERK2, has been shown to interact with regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a696739ea76f35a7a16e66991ab113
https://pubmed.ncbi.nlm.nih.gov/18801372
https://pubmed.ncbi.nlm.nih.gov/18801372
Autor:
Alan Kosaka, Stan Tsing, Eric Osen, James P. Barnett, Hardy S. O. Chan, Binh T. Nguyen, Bin Li, Chinh Bach
Human dopamine β-hydroxylase (DBH) has been expressed in transformed Drosophila Schneider 2 (S2) cells with yields of > 16 mg/l. Most of the activity was found in the culture fluid. Similarly, human neuroblastoma cells also secrete native DBH into t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d614736da22901067ac161f510ed6f
https://europepmc.org/articles/PMC1216909/
https://europepmc.org/articles/PMC1216909/