Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Stan J J Brouns"'
Autor:
Rebecca E McKenzie, Emma M Keizer, Jochem N A Vink, Jasper van Lopik, Ferhat Büke, Vera Kalkman, Christian Fleck, Sander J Tans, Stan J J Brouns
Publikováno v:
Molecular Systems Biology, Vol 18, Iss 4, Pp n/a-n/a (2022)
Abstract While CRISPR‐Cas defence mechanisms have been studied on a population level, their temporal dynamics and variability in individual cells have remained unknown. Using a microfluidic device, time‐lapse microscopy and mathematical modelling
Externí odkaz:
https://doaj.org/article/8a9a2760e38245d8812f6a9a0aaef882
Autor:
Sofie M Castelein, Tom F Aarts, Juergen Schleppi, Ruud Hendrikx, Amarante J Böttger, Dominik Benz, Maude Marechal, Advenit Makaya, Stan J J Brouns, Martin Schwentenwein, Anne S Meyer, Benjamin A E Lehner
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0249962 (2021)
In-situ resource utilization (ISRU) is increasingly acknowledged as an essential requirement for the construction of sustainable extra-terrestrial colonies. Even with decreasing launch costs, the ultimate goal of establishing colonies must be the usa
Externí odkaz:
https://doaj.org/article/48e8b745ddf34c66bd3072806a323e11
Autor:
Alex N Salazar, Franklin L Nobrega, Christine Anyansi, Cristian Aparicio-Maldonado, Ana Rita Costa, Anna C Haagsma, Anwar Hiralal, Ahmed Mahfouz, Rebecca E McKenzie, Teunke van Rossum, Stan J J Brouns, Thomas Abeel
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 1, p e1007314 (2020)
The last decade has witnessed a remarkable increase in our ability to measure genetic information. Advancements of sequencing technologies are challenging the existing methods of data storage and analysis. While methods to cope with the data deluge a
Externí odkaz:
https://doaj.org/article/6f872a9771584b79a7dacbeed69d8275
Autor:
Edze R Westra, Ekaterina Semenova, Kirill A Datsenko, Ryan N Jackson, Blake Wiedenheft, Konstantin Severinov, Stan J J Brouns
Publikováno v:
PLoS Genetics, Vol 9, Iss 9, p e1003742 (2013)
Discriminating self and non-self is a universal requirement of immune systems. Adaptive immune systems in prokaryotes are centered around repetitive loci called CRISPRs (clustered regularly interspaced short palindromic repeat), into which invader DN
Externí odkaz:
https://doaj.org/article/7fcfcc893ec948af900463be13e2fa17
Autor:
François P Douillard, Angela Ribbera, Ravi Kant, Taija E Pietilä, Hanna M Järvinen, Marcel Messing, Cinzia L Randazzo, Lars Paulin, Pia Laine, Jarmo Ritari, Cinzia Caggia, Tanja Lähteinen, Stan J J Brouns, Reetta Satokari, Ingemar von Ossowski, Justus Reunanen, Airi Palva, Willem M de Vos
Publikováno v:
PLoS Genetics, Vol 9, Iss 8, p e1003683 (2013)
Lactobacillus rhamnosus is a lactic acid bacterium that is found in a large variety of ecological habitats, including artisanal and industrial dairy products, the oral cavity, intestinal tract or vagina. To gain insights into the genetic complexity a
Externí odkaz:
https://doaj.org/article/75e057f4157b409fa291611ec10c9ffd
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35888 (2012)
BackgroundCRISPR/Cas is a widespread adaptive immune system in prokaryotes. This system integrates short stretches of DNA derived from invading nucleic acids into genomic CRISPR loci, which function as memory of previously encountered invaders. In Es
Externí odkaz:
https://doaj.org/article/af91329f8e294d7c85a725d3c62264d8
Autor:
Julia E. Egido, Catherine Toner-Bartelds, Ana Rita Costa, Stan J. J. Brouns, Suzan H. M. Rooijakkers, Bart W. Bardoel, Pieter-Jan Haas
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Bacteriophages (phages) are viruses that specifically attack bacteria. Their use as therapeutics, which constitutes a promising alternative to antibiotics, heavily relies on selecting effective lytic phages against the pathogen of interest.
Externí odkaz:
https://doaj.org/article/69c7c55bb74c4019bbaf24c109984a49
Autor:
Ruochen Ouyang, Ana Rita Costa, C. Keith Cassidy, Aleksandra Otwinowska, Vera C. J. Williams, Agnieszka Latka, Phill J. Stansfeld, Zuzanna Drulis-Kawa, Yves Briers, Daniël M. Pelt, Stan J. J. Brouns, Ariane Briegel
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The jumbo contractile bacteriophage, Kp24, has been isolated from clinical strains of Klebsiella pneumonia. Here, the authors present structural and functional insight into the capsid, tail and tail fibres and how this impacts infectivity.
Externí odkaz:
https://doaj.org/article/bff0aa3fd85c46f3a5c019f7cf4539c3
Autor:
Jack P. K. Bravo, Cristian Aparicio-Maldonado, Franklin L. Nobrega, Stan J. J. Brouns, David W. Taylor
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
DISARM (Defense Island System Associated with Restriction Modification) systems can provide bacteria with protection against a wide range of phage. Here, Bravo et al. determine cryo-EM structures of the core DISARM complex that shed light onto phage
Externí odkaz:
https://doaj.org/article/dced8bd6877849529f57e7386dedd6cf
Publikováno v:
Nature Reviews Microbiology. 21:21-34