Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Stan F J, van de Graaf"'
Autor:
Remco Kersten, David C. Trampert, Lowiek M. Hubers, Dagmar Tolenaars, Harmjan R. Vos, Stan F. J. van de Graaf, Ulrich Beuers
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Background and aimsIgG4-related cholangitis (IRC) is the hepatobiliary manifestation of IgG4-related disease, a systemic B cell-driven fibro-inflammatory disorder. Four autoantigens have recently been described in IgG4-RD: annexin A11, galectin-3, la
Externí odkaz:
https://doaj.org/article/9a8c0afbbd31453fad841b7992688e02
Autor:
Claudia Sacchetto, Laura Peretto, Francisco Baralle, Iva Maestri, Francesca Tassi, Francesco Bernardi, Stan F. J. van de Graaf, Franco Pagani, Mirko Pinotti, Dario Balestra
Publikováno v:
Molecular Medicine, Vol 27, Iss 1, Pp 1-12 (2021)
Abstract Background Aberrant splicing is a common outcome in the presence of exonic or intronic variants that might hamper the intricate network of interactions defining an exon in a specific gene context. Therefore, the evaluation of the functional,
Externí odkaz:
https://doaj.org/article/d971a21a3803407a8ffea7a8c1a6edd7
Autor:
Marileen M. C. Prins, Francesca P. Giugliano, Manon van Roest, Stan F. J. van de Graaf, Pim J. Koelink, Manon E. Wildenberg
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 4 (2021)
The ATG16L1 T300A single-nucleotide polymorphism (SNP) is associated with Crohn's disease and causes an autophagy impairment. We have previously shown that this SNP is involved in the migration and hyperactivation of Rac1 in dendritic cells. Mucosal
Externí odkaz:
https://doaj.org/article/cdc70577f24c46a7ab8a426149830b6d
Autor:
Dario Balestra, Mattia Ferrarese, Silvia Lombardi, Nicole Ziliotto, Alessio Branchini, Naomi Petersen, Piter Bosma, Mirko Pinotti, Stan F. J. van de Graaf
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 22, p 8735 (2020)
OTC splicing mutations are generally associated with the severest and early disease onset of ornithine transcarbamylase deficiency (OTCD), the most common urea cycle disorder. Noticeably, splicing defects can be rescued by spliceosomal U1snRNA varian
Externí odkaz:
https://doaj.org/article/50248ec1b1fc4dbe9b6fc0e3b5124a92
Autor:
Dario Balestra, Daniela Scalet, Mattia Ferrarese, Silvia Lombardi, Nicole Ziliotto, Chrystal C. Croes, Naomi Petersen, Piter Bosma, Federico Riccardi, Franco Pagani, Mirko Pinotti, Stan F. J. van de Graaf
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 6, p 2136 (2020)
The elucidation of aberrant splicing mechanisms, frequently associated with disease has led to the development of RNA therapeutics based on the U1snRNA, which is involved in 5′ splice site (5′ss) recognition. Studies in cellular models have demon
Externí odkaz:
https://doaj.org/article/7d2b03228a504040b8b832911c05fb85
Autor:
Monique D Appelman, Anindita Chakraborty, Ulrike Protzer, Jane A McKeating, Stan F J van de Graaf
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170419 (2017)
The sodium/bile acid cotransporter NTCP was recently identified as a receptor for hepatitis B virus (HBV). NTCP is glycosylated and the role of glycans in protein trafficking or viral receptor activity is not known. NTCP contains two N-linked glycosy
Externí odkaz:
https://doaj.org/article/aec617ab6d5a49679c3aeff70de4bd8e
Publikováno v:
Biochemical Pharmacology. 201
The liver controls the systemic exposure of amino acids entering via the gastro-intestinal tract. For most amino acids except branched chain amino acids, hepatic uptake is very efficient. This implies that the liver orchestrates amino acid metabolism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed685f43efff859ccc3304134168fef5
https://doi.org/10.1016/j.bcp.2022.115074
https://doi.org/10.1016/j.bcp.2022.115074
Publikováno v:
Gut. BMJ Publishing Group
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f21566c511b2602a1b92dd93f909e5ef
https://doi.org/10.1136/gutjnl-2021-326452
https://doi.org/10.1136/gutjnl-2021-326452
Autor:
Wendy L van der Woerd, Désirée Y van Haaften-Visser, Stan F J van de Graaf, Claude Férec, Emmanuelle Masson, Janneke M Stapelbroek, Peter Bugert, Heiko Witt, Roderick H J Houwen
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80553 (2013)
BackgroundMutations in genes encoding cationic trypsinogen (PRSS1), pancreatic secretory trypsin inhibitor (SPINK1) and chymotrypsinogen C (CTRC) are associated with chronic pancreatitis. However, in many patients with a familial chronic pancreatitis
Externí odkaz:
https://doaj.org/article/b90d8d07498a443c93be36298c0f66c2
Autor:
Monique D, Appelman, Marion J D, Robin, Esther W M, Vogels, Christie, Wolzak, Winnie G, Vos, Harmjan R, Vos, Robert M, Van Es, Boudewijn M T, Burgering, Stan F J, Van de Graaf
Publikováno v:
Cells
The sodium taurocholate cotransporting polypeptide (NTCP) is expressed at the basolateral membrane of hepatocytes, where it mediates the uptake of conjugated bile acids and forms the hepatocyte entry receptor for the hepatitis B and D virus. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e77d04c9feb193a3d82f2190000dd064
https://pubmed.ncbi.nlm.nih.gov/32316189
https://pubmed.ncbi.nlm.nih.gov/32316189