Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Stan Kupchinsky"'
Autor:
Michele Yang, Ganesh B. Bhat, Jacqui Elizabeth Hoffman, Andrea Fanjul, Stan Kupchinsky, Jacques Ermolieff, Klaus Ruprecht Dress, Cheng Hengmiao, Phuong Le, Jean Joo Matthews, Sajiv Krishnan Nair, Paul A. Rejto, T.A. Pauly, Evan Walters, Jocelyn Herrera, Christopher Ronald Smith, Martin Paul Edwards, Bridget Mccarthy Cole, Christine Loh, Cripps Stephan James, Natilie Hosea, Paderes Genevieve Deguzman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:2897-2902
The design and development of a series of highly selective pyrrolidine carboxamide 11β-HSD1 inhibitors are described. These compounds including PF-877423 demonstrated potent in vitro activity against both human and mouse 11β-HSD1 enzymes. In an in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d7e3703b61189e5ae86a3d7781fedd2
https://doi.org/10.1016/j.bmcl.2010.03.032
https://doi.org/10.1016/j.bmcl.2010.03.032
Autor:
Murphy Sean T, Gordon Alton, Xiao-Hong Yu, Stan Kupchinsky, Steven P. Tanis, Jacques Ermolieff, Tran Khanh Tuan, Min-Jean Yin, Sangita M. Baxi, William F. Vernier, Natasha M. Kablaoui, Michael J. Hickey, Benjamin J. Burke, John Charles Kath, Zhi Xie, Daniel Tyler Richter, John M. Humphrey, Michelle Kraus, RoseAnn Ferre, John Li, Matthew A. Marx, Thomas Allen Chappie, Samantha Elizabeth Greasley, Steven Kazmirski, Simon Bailey, Laura Lingardo
Publikováno v:
Journal of medicinal chemistry. 54(24)
Analogues substituted with various amines at the 6-position of the pyrazine ring on (4-amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)pyrazin-2-ylmethanone were discovered as potent and selective inhibitors of PDK1 with potential as anticancer age
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101b59a087b116c191559a0cc406942f
https://pubmed.ncbi.nlm.nih.gov/22040023
https://pubmed.ncbi.nlm.nih.gov/22040023
Autor:
Sean T. Murphy, Gordon Alton, Simon Bailey, Sangita M. Baxi, Benjamin J. Burke, Thomas A. Chappie, Jacques Ermolieff, RoseAnn Ferre, Samantha Greasley, Michael Hickey, John Humphrey, Natasha Kablaoui, John Kath, Steven Kazmirski, Michelle Kraus, Stan Kupchinsky, John Li, Laura Lingardo, Matthew A. Marx, Dan Richter
Publikováno v:
Journal of Medicinal Chemistry; Dec2011, Vol. 54 Issue 24, p8490-8500, 11p