Model-based assessment of replicability for genome-wide association meta-analysis

Autor: McGuire, Daniel, Jiang, Yu, Liu, Mengzhen, Weissenkampen, J. Dylan, Eckert, Scott, Yang, Lina, Chen, Fang, Liu, MengZhen, Wedow, Robbee, Li, Yue, Brazel, David M., Datta, Gargi, Davila-Velderrain, Jose, Tian, Chao, Zhan, Xiaowei, Choquet, H. éléne, Docherty, Anna R., Faul, Jessica D., Foerster, Johanna R., Fritsche, Lars, Gabrielsen, Maiken Elvestad, Gordon, Scott D., Haessler, Jeffrey, Hottenga, Jouke-Jan, Huang, Hongyan, Jang, Seon-Kyeong, Jansen, Philip R., Ling, Yueh, Ma ̈gi, Reedik, Matoba, Nana, McMahon, George, Mulas, Antonella, Orru, Valeria, Palviainen, Teemu, Pandit, Anita, Reginsson, Gunnar W., Skogholt, Anne Heidi, Smith, Jennifer A., Taylor, Amy E., Turman, Constance, Willemsen, Gonneke, Young, Hannah, Young, Kendra A., Zajac, Gregory J. M., Zhao, Wei, Zhou, Wei, Bjornsdottir, Gyda, Boardman, Jason D., Boehnke, Michael, Boomsma, Dorret I., Chen, Chu, Cucca, Francesco, Davies, Gareth E., Eaton, Charles B., Ehringer, Marissa A., Esko, Tõnu, Fiorillo, Edoardo, Gillespie, Nathan A., Gudbjartsson, Daniel F., Haller, Toomas, Harris, Kathleen Mullan, Heath, Andrew C., Hewitt, John K., Hickie, Ian B., Hokanson, John E., Hopfer, Christian J., Hunter, David J., Iacono, William G., Johnson, Eric O., Kamatani, Yoichiro, Kardia, Sharon L. R., Keller, Matthew C., Kellis, Manolis, Kooperberg, Charles, Kraft, Peter, Krauter, Kenneth S., Laakso, Markku, Lind, Penelope A., Loukola, Anu, Lutz, Sharon M., Madden, Pamela A. F., Martin, Nicholas G., McGue, Matt, McQueen, Matthew B., Medland, Sarah E., Metspalu, Andres, Mohlke, Karen L., Nielsen, Jonas B., Okada, Yukinori, Peters, Ulrike, Polderman, Tinca J. C., Posthuma, Danielle, Reiner, Alexander P., Rice, JP, Rimm, Eric, Rose, Richard J., Runarsdottir, Valgerdur, Stallings, Michael C., Stanˇca ́kova, Alena, Stefansson, Hreinn, Thai, Khanh K., Tindle, Hilary A., Tyrfingsson, Thorarinn, Wall, Tamara L., Weir, David R., Weisner, Constance M, Whitfield, John B., Winsvold, Bendik K S, Yin, Jie, Zuccolo, Luisa, Bierut, Laura J., Hveem, Kristian, Lee, James J., Munafo, Marcus R., Saccone, Nancy L., Willer, Cristen J, Cornelis, Marilyn C., David, Sean P., Hinds, David, Jorgenson, Eric, Kaprio, Jaakko, Stitzel, Jerry A., Stefansson, Kari, Thorgeirsson, Thorgeir E., Abecasis, Goncalo, Liu, Dajiang J., Vrieze, Scott, Berg, Arthur, Jiang, Bibo, Li, Qunhua

Publikováno v: Nature Communications
GWAS and Sequencing Consortium of Alcohol and Nicotine Use (GSCAN) 2021, ' Model-based assessment of replicability for genome-wide association meta-analysis ', Nature Communications, vol. 12, no. 1, 1964 . https://doi.org/10.1038/s41467-021-21226-z
Nature Communications, 12(1):1964. Nature Publishing Group
McGuire, D, Hottenga, J J, Jansen, P R, Willemsen, G, Boomsma, D I, Polderman, T J C, Posthuma, D, Jiang, B, Liu, D J & GWAS and Sequencing Consortium of Alcohol and Nicotine Use (GSCAN) 2021, ' Model-based assessment of replicability for genome-wide association meta-analysis ', Nature Communications, vol. 12, 1964, pp. 1-14 . https://doi.org/10.1038/s41467-021-21226-z
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, 12:1964, 1-14. Nature Publishing Group

Genome-wide association meta-analysis (GWAMA) is an effective approach to enlarge sample sizes and empower the discovery of novel associations between genotype and phenotype. Independent replication has been used as a gold-standard for validating gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0e241167021112a8b09c28d196d9ada
http://europepmc.org/articles/PMC8009871

Effect of X-ray free-electron laser-induced shockwaves on haemoglobin microcrystals delivered in a liquid jet.

Autor: Grünbein ML; Max Planck Institute for Medical Research, Jahnstrasse 29, Heidelberg, Germany., Gorel A; Max Planck Institute for Medical Research, Jahnstrasse 29, Heidelberg, Germany., Foucar L; Max Planck Institute for Medical Research, Jahnstrasse 29, Heidelberg, Germany., Carbajo S; SLAC National Accelerator Laboratory, Menlo Park, CA, USA., Colocho W; SLAC National Accelerator Laboratory, Menlo Park, CA, USA., Gilevich S; SLAC National Accelerator Laboratory, Menlo Park, CA, USA., Hartmann E; Max Planck Institute for Medical Research, Jahnstrasse 29, Heidelberg, Germany., Hilpert M; Max Planck Institute for Medical Research, Jahnstrasse 29, Heidelberg, Germany., Hunter M; SLAC National Accelerator Laboratory, Menlo Park, CA, USA., Kloos M; Max Planck Institute for Medical Research, Jahnstrasse 29, Heidelberg, Germany.; European XFEL GmbH, Schenefeld, Germany., Koglin JE; SLAC National Accelerator Laboratory, Menlo Park, CA, USA.; Los Alamos National Laboratory, Los Alamos, NM, USA., Lane TJ; SLAC National Accelerator Laboratory, Menlo Park, CA, USA.; Center for Free-Electron Laser Science, DESY, Hamburg, Germany., Lewandowski J; SLAC National Accelerator Laboratory, Menlo Park, CA, USA., Lutman A; SLAC National Accelerator Laboratory, Menlo Park, CA, USA., Nass K; Max Planck Institute for Medical Research, Jahnstrasse 29, Heidelberg, Germany.; Paul Scherrer Institut, Villigen, Switzerland., Nass Kovacs G; Max Planck Institute for Medical Research, Jahnstrasse 29, Heidelberg, Germany., Roome CM; Max Planck Institute for Medical Research, Jahnstrasse 29, Heidelberg, Germany., Sheppard J; SLAC National Accelerator Laboratory, Menlo Park, CA, USA., Shoeman RL; Max Planck Institute for Medical Research, Jahnstrasse 29, Heidelberg, Germany., Stricker M; Max Planck Institute for Medical Research, Jahnstrasse 29, Heidelberg, Germany.; Department of Statistics, University of Oxford, Oxford, UK., van Driel T; SLAC National Accelerator Laboratory, Menlo Park, CA, USA., Vetter S; SLAC National Accelerator Laboratory, Menlo Park, CA, USA., Doak RB; Max Planck Institute for Medical Research, Jahnstrasse 29, Heidelberg, Germany., Boutet S; SLAC National Accelerator Laboratory, Menlo Park, CA, USA., Aquila A; SLAC National Accelerator Laboratory, Menlo Park, CA, USA., Decker FJ; SLAC National Accelerator Laboratory, Menlo Park, CA, USA., Barends TRM; Max Planck Institute for Medical Research, Jahnstrasse 29, Heidelberg, Germany., Stan CA; Department of Physics, Rutgers University Newark, Newark, NJ, USA. claudiu.stan@rutgers.edu., Schlichting I; Max Planck Institute for Medical Research, Jahnstrasse 29, Heidelberg, Germany. ilme.schlichting@mpimf-heidelberg.mpg.de.

Publikováno v: Nature communications [Nat Commun] 2021 Mar 15; Vol. 12 (1), pp. 1672. Date of Electronic Publication: 2021 Mar 15.

Megahertz serial crystallography.

Autor: Wiedorn MO; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.; Department of Physics, Universität Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany.; The Hamburg Center for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany., Oberthür D; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany., Bean R; European XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany., Schubert R; The Hamburg Center for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany.; Institute for Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, Universität Hamburg, Notkestrasse 85, 22607, Hamburg, Germany.; Integrated Biology Infrastructure Life-Science Facility at the European XFEL (XBI), Holzkoppel 4, 22869, Schenefeld, Germany., Werner N; Institute for Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, Universität Hamburg, Notkestrasse 85, 22607, Hamburg, Germany., Abbey B; Australian Research Council (ARC) Centre of Excellence in Advanced Molecular Imaging, Department of Chemistry and Physics, La Trobe Institute for Molecular Sciences, La Trobe University, Bundoora, VIC, 3086, Australia., Aepfelbacher M; Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf (UKE), 20246, Hamburg, Germany., Adriano L; Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany., Allahgholi A; Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany., Al-Qudami N; European XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany., Andreasson J; Laboratory of Molecular Biophysics, Department of Cell and Molecular Biology, Uppsala University, Uppsala, 751 24, Sweden.; ELI Beamlines, Institute of Physics of the Czech Academy of Sciences, Na Slovance 2, 182 21, Prague, Czech Republic.; Condensed Matter Physics, Department of Physics, Chalmers University of Technology, Gothenburg, 412 96, Sweden., Aplin S; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany., Awel S; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.; The Hamburg Center for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany., Ayyer K; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany., Bajt S; Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany., Barák I; Institute of Molecular Biology, SAS, Dubravska cesta 21, 845 51, Bratislava, Slovakia., Bari S; Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany., Bielecki J; European XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany., Botha S; The Hamburg Center for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany.; Institute for Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, Universität Hamburg, Notkestrasse 85, 22607, Hamburg, Germany., Boukhelef D; European XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany., Brehm W; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany., Brockhauser S; European XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.; Biological Research Centre (BRC), Hungarian Academy of Sciences, Temesvári krt. 62, Szeged, 6726, Hungary., Cheviakov I; Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf (UKE), 20246, Hamburg, Germany., Coleman MA; Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA, 94550, USA., Cruz-Mazo F; Depart. Ingeniería Aeroespacial y Mecánica de Fluidos ETSI, Universidad de Sevilla, 41092, Sevilla, Spain., Danilevski C; European XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany., Darmanin C; Australian Research Council (ARC) Centre of Excellence in Advanced Molecular Imaging, Department of Chemistry and Physics, La Trobe Institute for Molecular Sciences, La Trobe University, Bundoora, VIC, 3086, Australia., Doak RB; Max Planck Institute for Medical Research, Jahnstr. 29, 69120, Heidelberg, Germany., Domaracky M; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany., Dörner K; European XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany., Du Y; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany., Fangohr H; European XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.; Engineering and the Environment, University of Southampton, SO17 1BJ, Southampton, UK., Fleckenstein H; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany., Frank M; Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA, 94550, USA., Fromme P; School of Molecular Sciences and Biodesign Center for Applied Structural Discovery, Arizona State University, Tempe, AZ, 85287-1604, USA., Gañán-Calvo AM; Depart. Ingeniería Aeroespacial y Mecánica de Fluidos ETSI, Universidad de Sevilla, 41092, Sevilla, Spain., Gevorkov Y; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.; Hamburg University of Technology, Vision Systems E-2, Harburger Schloßstr. 20, 21079, Hamburg, Germany., Giewekemeyer K; European XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany., Ginn HM; Division of Structural Biology, Headington, Oxford, OX3 7BN, UK.; Diamond Light Source, Research Complex at Harwell, and University of Oxford, Diamond House, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0DE, UK., Graafsma H; Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.; Mid Sweden University, Holmgatan 10, 85170, Sundsvall, Sweden., Graceffa R; European XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany., Greiffenberg D; Paul Scherrer Institut, Forschungsstrasse 111, 5232, Villigen, Switzerland., Gumprecht L; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany., Göttlicher P; Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany., Hajdu J; Laboratory of Molecular Biophysics, Department of Cell and Molecular Biology, Uppsala University, Uppsala, 751 24, Sweden.; ELI Beamlines, Institute of Physics of the Czech Academy of Sciences, Na Slovance 2, 182 21, Prague, Czech Republic., Hauf S; European XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany., Heymann M; Department of Cellular and Molecular Biophysics, Max Planck Institute of Biochemistry, 82152, Martinsried, Germany., Holmes S; Australian Research Council (ARC) Centre of Excellence in Advanced Molecular Imaging, Department of Chemistry and Physics, La Trobe Institute for Molecular Sciences, La Trobe University, Bundoora, VIC, 3086, Australia., Horke DA; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.; The Hamburg Center for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany., Hunter MS; Linac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, 94025, CA, USA., Imlau S; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany., Kaukher A; European XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany., Kim Y; European XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany., Klyuev A; Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany., Knoška J; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.; Department of Physics, Universität Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany., Kobe B; School of Chemistry and Molecular Biosciences, Institute for Molecular Bioscience and Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, QLD, 4072, Australia., Kuhn M; Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany., Kupitz C; Physics Department, University of Wisconsin-Milwaukee, 3135 N. Maryland Ave, Milwaukee, WI, 53211, USA., Küpper J; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.; Department of Physics, Universität Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany.; The Hamburg Center for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany.; Department of Chemistry, Universität Hamburg, Martin-Luther-King Platz 6, 20146, Hamburg, Germany., Lahey-Rudolph JM; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.; Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany., Laurus T; Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany., Le Cong K; Institute for Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, Universität Hamburg, Notkestrasse 85, 22607, Hamburg, Germany., Letrun R; European XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany., Xavier PL; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.; Max-Planck Institute for the Structure and Dynamics of Matter, Luruper Chaussee 149, 22761, Hamburg, Germany., Maia L; European XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany., Maia FRNC; Laboratory of Molecular Biophysics, Department of Cell and Molecular Biology, Uppsala University, Uppsala, 751 24, Sweden.; NERSC, Lawrence Berkeley National Laboratory, Berkeley, 94720, CA, USA., Mariani V; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany., Messerschmidt M; European XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany., Metz M; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany., Mezza D; Paul Scherrer Institut, Forschungsstrasse 111, 5232, Villigen, Switzerland., Michelat T; European XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany., Mills G; European XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany., Monteiro DCF; The Hamburg Center for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany., Morgan A; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany., Mühlig K; Laboratory of Molecular Biophysics, Department of Cell and Molecular Biology, Uppsala University, Uppsala, 751 24, Sweden., Munke A; Laboratory of Molecular Biophysics, Department of Cell and Molecular Biology, Uppsala University, Uppsala, 751 24, Sweden., Münnich A; European XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany., Nette J; The Hamburg Center for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany., Nugent KA; Australian Research Council (ARC) Centre of Excellence in Advanced Molecular Imaging, Department of Chemistry and Physics, La Trobe Institute for Molecular Sciences, La Trobe University, Bundoora, VIC, 3086, Australia., Nuguid T; Institute for Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, Universität Hamburg, Notkestrasse 85, 22607, Hamburg, Germany., Orville AM; Diamond Light Source, Research Complex at Harwell, and University of Oxford, Diamond House, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0DE, UK., Pandey S; Physics Department, University of Wisconsin-Milwaukee, 3135 N. Maryland Ave, Milwaukee, WI, 53211, USA., Pena G; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany., Villanueva-Perez P; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany., Poehlsen J; Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany., Previtali G; European XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany., Redecke L; Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf (UKE), 20246, Hamburg, Germany.; Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany., Riekehr WM; Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany., Rohde H; Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf (UKE), 20246, Hamburg, Germany., Round A; European XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany., Safenreiter T; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany., Sarrou I; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany., Sato T; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.; European XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany., Schmidt M; Physics Department, University of Wisconsin-Milwaukee, 3135 N. Maryland Ave, Milwaukee, WI, 53211, USA., Schmitt B; Paul Scherrer Institut, Forschungsstrasse 111, 5232, Villigen, Switzerland., Schönherr R; Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany., Schulz J; European XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany., Sellberg JA; Biomedical and X-Ray Physics, Department of Applied Physics, AlbaNova University Center, KTH Royal Institute of Technology, Stockholm, 106 91, Sweden., Seibert MM; Laboratory of Molecular Biophysics, Department of Cell and Molecular Biology, Uppsala University, Uppsala, 751 24, Sweden., Seuring C; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.; The Hamburg Center for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany., Shelby ML; Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA, 94550, USA., Shoeman RL; Max Planck Institute for Medical Research, Jahnstr. 29, 69120, Heidelberg, Germany., Sikorski M; European XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany., Silenzi A; European XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany., Stan CA; Physics Department, Rutgers University Newark, Newark, NJ, 07102, USA., Shi X; Paul Scherrer Institut, Forschungsstrasse 111, 5232, Villigen, Switzerland., Stern S; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.; European XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany., Sztuk-Dambietz J; European XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany., Szuba J; European XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany., Tolstikova A; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany., Trebbin M; The Hamburg Center for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany.; Department of Chemistry, University at Buffalo, 359 Natural Sciences Complex, Buffalo, NY, 14260, USA.; Institute of Nanostructure and Solid State Physics, Department of Physics, Universität Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany., Trunk U; Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany., Vagovic P; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.; European XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany., Ve T; Institute for Glycomics, Griffith University, Southport, QLD, 4222, Australia., Weinhausen B; European XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany., White TA; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany., Wrona K; European XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany., Xu C; European XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany., Yefanov O; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany., Zatsepin N; Department of Physics, Arizona State University, Tempe, AZ, 85287, USA., Zhang J; Paul Scherrer Institut, Forschungsstrasse 111, 5232, Villigen, Switzerland., Perbandt M; The Hamburg Center for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany.; Institute for Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, Universität Hamburg, Notkestrasse 85, 22607, Hamburg, Germany.; Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf (UKE), 20246, Hamburg, Germany., Mancuso AP; European XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany., Betzel C; The Hamburg Center for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany.; Institute for Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, Universität Hamburg, Notkestrasse 85, 22607, Hamburg, Germany.; Integrated Biology Infrastructure Life-Science Facility at the European XFEL (XBI), Holzkoppel 4, 22869, Schenefeld, Germany., Chapman H; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany. henry.chapman@desy.de.; Department of Physics, Universität Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany. henry.chapman@desy.de.; The Hamburg Center for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany. henry.chapman@desy.de., Barty A; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany. anton.barty@desy.de.

Publikováno v: Nature communications [Nat Commun] 2018 Oct 02; Vol. 9 (1), pp. 4025. Date of Electronic Publication: 2018 Oct 02.

Rapid sample delivery for megahertz serial crystallography at X-ray FELs.

Autor: Wiedorn MO; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607 Hamburg, Germany.; Department of Physics, Universität Hamburg, Luruper Chaussee 149, 22761 Hamburg, Germany.; The Hamburg Center for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761 Hamburg, Germany., Awel S; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607 Hamburg, Germany.; The Hamburg Center for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761 Hamburg, Germany., Morgan AJ; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607 Hamburg, Germany., Ayyer K; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607 Hamburg, Germany., Gevorkov Y; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607 Hamburg, Germany.; Institute of Vision Systems, Hamburg University of Technology, Harburger Schlossstrasse 20, 21079 Hamburg, Germany., Fleckenstein H; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607 Hamburg, Germany., Roth N; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607 Hamburg, Germany.; Department of Physics, Universität Hamburg, Luruper Chaussee 149, 22761 Hamburg, Germany., Adriano L; Photon Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany., Bean R; European XFEL GmbH, Holzkoppel 4, 22869 Schenefeld, Germany., Beyerlein KR; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607 Hamburg, Germany., Chen J; Arizona State University, 550 E. Tyler Drive, Tempe, AZ 85287, USA., Coe J; Arizona State University, 550 E. Tyler Drive, Tempe, AZ 85287, USA., Cruz-Mazo F; Universidad de Sevilla, Department of Aerospace Engineering and Fluid Mechanics, Camino de los Descubriemientos s/n, 41092 Sevilla, Spain., Ekeberg T; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607 Hamburg, Germany., Graceffa R; European XFEL GmbH, Holzkoppel 4, 22869 Schenefeld, Germany., Heymann M; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607 Hamburg, Germany.; Max Planck Institute of Biochemistry, Department of Cellular and Molecular Biophysics, 82152 Martinsried, Germany., Horke DA; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607 Hamburg, Germany.; The Hamburg Center for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761 Hamburg, Germany., Knoška J; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607 Hamburg, Germany.; Department of Physics, Universität Hamburg, Luruper Chaussee 149, 22761 Hamburg, Germany., Mariani V; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607 Hamburg, Germany., Nazari R; Arizona State University, 550 E. Tyler Drive, Tempe, AZ 85287, USA., Oberthür D; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607 Hamburg, Germany., Samanta AK; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607 Hamburg, Germany., Sierra RG; LCLS, SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025, USA., Stan CA; Department of Physics, Rutgers University Newark, Newark, NJ 07102, USA.; Stanford PULSE Institute, SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025, USA., Yefanov O; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607 Hamburg, Germany., Rompotis D; Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607 Hamburg, Germany., Correa J; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607 Hamburg, Germany.; Photon Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany., Erk B; Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607 Hamburg, Germany., Treusch R; Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607 Hamburg, Germany., Schulz J; European XFEL GmbH, Holzkoppel 4, 22869 Schenefeld, Germany., Hogue BG; Biodesign Institute, School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA., Gañán-Calvo AM; Universidad de Sevilla, Department of Aerospace Engineering and Fluid Mechanics, Camino de los Descubriemientos s/n, 41092 Sevilla, Spain., Fromme P; Arizona State University, 550 E. Tyler Drive, Tempe, AZ 85287, USA.; Biodesign Institute, School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA., Küpper J; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607 Hamburg, Germany.; Department of Physics, Universität Hamburg, Luruper Chaussee 149, 22761 Hamburg, Germany.; The Hamburg Center for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761 Hamburg, Germany., Rode AV; Laser Physics Centre, Research School of Physics and Engineering, Australian National University, Canberra, ACT 2601, Australia., Bajt S; Photon Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany., Kirian RA; Arizona State University, 550 E. Tyler Drive, Tempe, AZ 85287, USA., Chapman HN; Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607 Hamburg, Germany.; Department of Physics, Universität Hamburg, Luruper Chaussee 149, 22761 Hamburg, Germany.; The Hamburg Center for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761 Hamburg, Germany.

Publikováno v: IUCrJ [IUCrJ] 2018 Jul 27; Vol. 5 (Pt 5), pp. 574-584. Date of Electronic Publication: 2018 Jul 27 (Print Publication: 2018).

Drop-on-demand sample delivery for studying biocatalysts in action at X-ray free-electron lasers.

Autor: Fuller FD; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA., Gul S; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA., Chatterjee R; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA., Burgie ES; Department of Biology, Washington University in St. Louis, St. Louis, Missouri, USA., Young ID; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA., Lebrette H; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden., Srinivas V; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden., Brewster AS; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA., Michels-Clark T; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA., Clinger JA; Department of BioSciences, Rice University, Houston, Texas, USA., Andi B; National Synchrotron Light Source II, Brookhaven National Laboratory, Upton, New York, USA., Ibrahim M; Institut für Biologie, Humboldt-Universität zu Berlin, Berlin, Germany., Pastor E; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA., de Lichtenberg C; Institutionen för Kemi, Kemiskt Biologiskt Centrum, Umeå Universitet, Umeå, Sweden., Hussein R; Institut für Biologie, Humboldt-Universität zu Berlin, Berlin, Germany., Pollock CJ; Department of Chemistry, Pennsylvania State University, University Park, Pennsylvania, USA., Zhang M; Institut für Biologie, Humboldt-Universität zu Berlin, Berlin, Germany., Stan CA; Stanford PULSE Institute, SLAC National Accelerator Laboratory, Menlo Park, California, USA., Kroll T; SSRL, SLAC National Accelerator Laboratory, Menlo Park, California, USA., Fransson T; Stanford PULSE Institute, SLAC National Accelerator Laboratory, Menlo Park, California, USA., Weninger C; Stanford PULSE Institute, SLAC National Accelerator Laboratory, Menlo Park, California, USA.; LCLS, SLAC National Accelerator Laboratory, Menlo Park, California, USA., Kubin M; Institute for Methods and Instrumentation on Synchrotron Radiation Research, Helmholtz Zentrum Berlin für Materialien und Energie GmbH, Berlin, Germany., Aller P; Diamond Light Source Limited, Harwell Science and Innovation Campus, Didcot, UK., Lassalle L; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA., Bräuer P; Diamond Light Source Limited, Harwell Science and Innovation Campus, Didcot, UK.; Department of Biochemistry, University of Oxford, Oxford, UK., Miller MD; Department of BioSciences, Rice University, Houston, Texas, USA., Amin M; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA., Koroidov S; Institutionen för Kemi, Kemiskt Biologiskt Centrum, Umeå Universitet, Umeå, Sweden.; Stanford PULSE Institute, SLAC National Accelerator Laboratory, Menlo Park, California, USA., Roessler CG; National Synchrotron Light Source II, Brookhaven National Laboratory, Upton, New York, USA., Allaire M; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA., Sierra RG; LCLS, SLAC National Accelerator Laboratory, Menlo Park, California, USA., Docker PT; Diamond Light Source Limited, Harwell Science and Innovation Campus, Didcot, UK., Glownia JM; LCLS, SLAC National Accelerator Laboratory, Menlo Park, California, USA., Nelson S; LCLS, SLAC National Accelerator Laboratory, Menlo Park, California, USA., Koglin JE; LCLS, SLAC National Accelerator Laboratory, Menlo Park, California, USA., Zhu D; LCLS, SLAC National Accelerator Laboratory, Menlo Park, California, USA., Chollet M; LCLS, SLAC National Accelerator Laboratory, Menlo Park, California, USA., Song S; LCLS, SLAC National Accelerator Laboratory, Menlo Park, California, USA., Lemke H; LCLS, SLAC National Accelerator Laboratory, Menlo Park, California, USA., Liang M; LCLS, SLAC National Accelerator Laboratory, Menlo Park, California, USA., Sokaras D; SSRL, SLAC National Accelerator Laboratory, Menlo Park, California, USA., Alonso-Mori R; LCLS, SLAC National Accelerator Laboratory, Menlo Park, California, USA., Zouni A; Institut für Biologie, Humboldt-Universität zu Berlin, Berlin, Germany., Messinger J; Institutionen för Kemi, Kemiskt Biologiskt Centrum, Umeå Universitet, Umeå, Sweden.; Department of Chemistry-Ångström, Molecular Biomimetics, Uppsala University, Uppsala, Sweden., Bergmann U; Stanford PULSE Institute, SLAC National Accelerator Laboratory, Menlo Park, California, USA., Boal AK; Department of Chemistry, Pennsylvania State University, University Park, Pennsylvania, USA.; Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA., Bollinger JM Jr; Department of Chemistry, Pennsylvania State University, University Park, Pennsylvania, USA.; Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA., Krebs C; Department of Chemistry, Pennsylvania State University, University Park, Pennsylvania, USA.; Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA., Högbom M; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.; Department of Chemistry, Stanford University, Stanford, California, USA., Phillips GN Jr; Department of BioSciences, Rice University, Houston, Texas, USA.; Department of Chemistry, Rice University, Houston, Texas, USA., Vierstra RD; Department of Biology, Washington University in St. Louis, St. Louis, Missouri, USA., Sauter NK; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA., Orville AM; Diamond Light Source Limited, Harwell Science and Innovation Campus, Didcot, UK., Kern J; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA.; LCLS, SLAC National Accelerator Laboratory, Menlo Park, California, USA., Yachandra VK; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA., Yano J; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA.

Publikováno v: Nature methods [Nat Methods] 2017 Apr; Vol. 14 (4), pp. 443-449. Date of Electronic Publication: 2017 Feb 27.