Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Stalled forks"'
Autor:
Laurence Signon
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 2, Pp 737-752 (2018)
Paused or stalled replication forks are major threats to genome integrity; unraveling the complex pathways that contribute to fork stability and restart is crucial. Experimentally, fork stalling is induced by growing the cells in presence of hydroxyu
Externí odkaz:
https://doaj.org/article/ab206f34e1494bc7a33a5c052563d4c2
Akademický článek
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Akademický článek
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Autor:
Jonathan M.G. Higgins, Rolando Berlinguer-Palmini, Daniel Rico, Rossitsa Hristova, Inmaculada Hernandez, Anastas Gospodinov, Urszula L. McClurg, Manolis Papamichos-Chronakis, Philippe Pasero, Sarah Greener, Lisa Prendergast, Katie Veitch
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications
Nature Communications
Collisions between the DNA replication machinery and co-transcriptional R-loops can impede DNA synthesis and are a major source of genomic instability in cancer cells. How cancer cells deal with R-loops to proliferate is poorly understood. Here we sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94863d6502252d0111047beb6f4559a7
https://doaj.org/article/dcd1345330a848728d9de1a0310ef7f0
https://doaj.org/article/dcd1345330a848728d9de1a0310ef7f0
Autor:
Claudia M. Nicolae, Wendy Leung, Tanay Thakar, Binghui Shen, Kristen E. Clements, George Lucian Moldovan, Anja Katrin Bielinsky
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Upon genotoxic stress, PCNA ubiquitination allows for replication of damaged DNA by recruiting lesion-bypass DNA polymerases. However, PCNA is also ubiquitinated during normal S-phase progression. By employing 293T and RPE1 cells deficient in PCNA ub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ab0d8a0f31b7f5060a44c85f685ae1
http://link.springer.com/article/10.1038/s41467-020-16096-w
http://link.springer.com/article/10.1038/s41467-020-16096-w
Autor:
Sanket Awate, Kajal Biswas, Joshua A. Sommers, Shyam K. Sharan, Tanay Thakar, Claudia M. Nicolae, Robert M. Brosh, Arindam Datta, Robert H. Shoemaker, Haley Thompson, George Lucian Moldovan
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
The tumor suppressor BRCA2 protects stalled forks from degradation to maintain genome stability. However, the molecular mechanism(s) whereby unprotected forks are stabilized remains to be fully characterized. Here, we demonstrate that WRN helicase en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e210a722a7a0e708b03ea79b23fee25
http://europepmc.org/articles/PMC8590011
http://europepmc.org/articles/PMC8590011
Autor:
Caiyong Ye, Anja Katrin Bielinsky, Bing Xia, Zhihua Kang, Yamei Zuo, Pan Fu, Mirit I. Aladjem, Ryan M. Baxley, Christophe E. Redon, Lee Zou, Advaitha Madireddy, Zhiyuan Shen, Rémi Buisson, Tzeh Keong Foo, Haiqing Fu, Allen L. Alcivar
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
The BRCA2 tumor suppressor protects genome integrity by promoting homologous recombination-based repair of DNA breaks, stability of stalled DNA replication forks and DNA damage-induced cell cycle checkpoints. BRCA2 deficient cells display the radio-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93cf269e58860fb67e6569b333099490
https://escholarship.org/uc/item/5s91p0w3
https://escholarship.org/uc/item/5s91p0w3
Autor:
Su Hyung Park, Sungchul Hohng, Minwoo Wie, Sukhyun Kang, KS Lee, Deokjae Lee, Jun Hong Park, Jae Sun Ra, In Bae Park, Sunyoung Hwang, Eun-Ho Song, Kyungjae Myung, Jieun Park, Eun A. Lee, Nalae Kang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
Maintaining stability of replication forks is important for genomic integrity. However, it is not clear how replisome proteins contribute to fork stability under replication stress. Here, we report that ATAD5, a PCNA unloader, plays multiple function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d195193d86b9525d6ad23ad3d26d42d6
https://doaj.org/article/4ac4913c149c4dd78292e37f24a832b8
https://doaj.org/article/4ac4913c149c4dd78292e37f24a832b8
Autor:
Nana Rokutanda, Tomohiko Ohta, Yongqiang Lai, Yukiko Togashi, Mingzhang Zhu, Wenwen Wu, Weixin Liang
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
Replication protein A (RPA) binds to and stabilizes single-stranded DNA and is essential for the genome stability. We reported that an E3 ubiquitin ligase, HERC2, suppresses G-quadruplex (G4) DNA by regulating RPA-helicase complexes. However, the pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4330db07309c40e28a23c60313be2fe
http://link.springer.com/article/10.1038/s41598-019-50812-x
http://link.springer.com/article/10.1038/s41598-019-50812-x
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
Nature Communications
The central recombination enzyme RAD51 has been implicated in replication fork processing and restart in response to replication stress. Here, we use a separation-of-function allele of RAD51 that retains DNA binding, but not D-loop activity, to revea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1790a224c6367fed841d9e2be58468c3
http://link.springer.com/article/10.1038/s41467-019-12297-0
http://link.springer.com/article/10.1038/s41467-019-12297-0