Zobrazeno 1 - 10
of 2 162
pro vyhledávání: '"Stainier, A."'
Publikováno v:
Computer Methods in Applied Mechanics and Engineering (2024)
We present a comparison between two approaches to modelling hyperelastic material behaviour using data. The first approach is a novel approach based on Data-driven Computational Mechanics (DDCM) that completely bypasses the definition of a material m
Externí odkaz:
http://arxiv.org/abs/2409.06727
Publikováno v:
Computer Methods in Applied Mechanics and Engineering, 429, 117180 (2024)
This paper explores the role of generalized continuum mechanics, and the feasibility of model-free data-driven computing approaches thereof, in solids undergoing failure by strain localization. Specifically, we set forth a methodology for capturing m
Externí odkaz:
http://arxiv.org/abs/2402.15966
Autor:
Nicole Schmitner, Sophie Thumer, Dominik Regele, Elena Mayer, Ines Bergerweiss, Christian Helker, Didier Y. R. Stainier, Dirk Meyer, Robin A. Kimmel
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Glucokinase (GCK) is an essential enzyme for blood glucose homeostasis. Because of its importance in glucose metabolism, GCK is considered an attractive target for the development of antidiabetic drugs. However, a viable therapeutic agent ha
Externí odkaz:
https://doaj.org/article/b19fdd15f38c488eaa3129b45e9e8692
We formulate a class of velocity-free finite-particle methods for mass transport problems based on a time-discrete incremental variational principle that combines entropy and the cost of particle transport, as measured by the Wasserstein metric. The
Externí odkaz:
http://arxiv.org/abs/2305.05315
Autor:
Marga Albu, Eileen Affolter, Alessandra Gentile, Yanli Xu, Khrievono Kikhi, Sarah Howard, Carsten Kuenne, Rashmi Priya, Felix Gunawan, Didier Y. R. Stainier
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Tissues undergo distinct morphogenetic processes to achieve similarly shaped structures. In the heart, cardiomyocytes in both the ventricle and atrium build internal structures for efficient contraction. Ventricular wall formation (trabecula
Externí odkaz:
https://doaj.org/article/a55a62305a4c491d8c45ee1f4c8ef7c5
Autor:
Dorothee Bornhorst, Amulya V. Hejjaji, Lena Steuter, Nicole M. Woodhead, Paul Maier, Alessandra Gentile, Alice Alhajkadour, Octavia Santis Larrain, Michael Weber, Khrievono Kikhi, Stefan Guenther, Jan Huisken, Owen J. Tamplin, Didier Y. R. Stainier, Felix Gunawan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The contribution of endocardial cells (EdCs) to the hematopoietic lineages has been strongly debated. Here, we provide evidence that in zebrafish, the endocardium gives rise to and maintains a stable population of hematopoietic cells. Using
Externí odkaz:
https://doaj.org/article/3c92a8d2890d4f36b9229198535cf10f
Autor:
Ziying Liu, Chunyan Lu, Li Ma, Changjiang Li, Haiyun Luo, Yiqi Liu, Xinyuan Liu, Haiqing Li, Yachao Cui, Jiahang Zeng, Natalia Bottasso‐Arias, Debora Sinner, Le Li, Jian Wang, Didier Y. R. Stainier, Wenguang Yin
Publikováno v:
Advanced Science, Vol 11, Iss 44, Pp n/a-n/a (2024)
Abstract Abnormalities of tracheal smooth muscle (SM) formation are associated with several clinical disorders including tracheal stenosis and tracheomalacia. However, the cellular and molecular mechanisms underlying tracheal SM formation remain poor
Externí odkaz:
https://doaj.org/article/8e921e1b85084c32a1f45689b90f74a4
Autor:
João Cardeira-da-Silva, Qianchen Wang, Pooja Sagvekar, Janita Mintcheva, Stephan Latting, Stefan Günther, Radhan Ramadass, Michail Yekelchyk, Jens Preussner, Mario Looso, Jan Philipp Junker, Didier Y. R. Stainier
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract In contrast to adult mammals, adult zebrafish can fully regenerate injured cardiac tissue, and this regeneration process requires an adequate and tightly controlled immune response. However, which components of the immune response are requir
Externí odkaz:
https://doaj.org/article/5d1f445d3f7a43f69b32b517875250bd
Publikováno v:
In Computer Methods in Applied Mechanics and Engineering 1 February 2024 419
The data-driven computing paradigm initially introduced by Kirchdoerfer and Ortiz (2016) enables finite element computations in solid mechanics to be performed directly from material data sets, without an explicit material model. From a computational
Externí odkaz:
http://arxiv.org/abs/2012.00357