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of 28
pro vyhledávání: '"Stahlberg, Markus A."'
Autor:
Stahlberg, Markus A., Ramakrishnan, Charu, Willig, Katrin I., Boyden, Edward S., Deisseroth, Karl, Dean, Camin
Optogenetics has revolutionized the study of circuit function in the brain, by allowing activation of specific ensembles of neurons by light. However, this technique has not yet been exploited extensively at the subcellular level. Here, we test the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1688::5d251551d9ed7959a1e5b6128fd7f7a5
http://resolver.sub.uni-goettingen.de/purl?gs-1/15860
http://resolver.sub.uni-goettingen.de/purl?gs-1/15860
Autor:
Masaracchia, Caterina, Hnida, Marilena, Gerhardt, Ellen, Fonseca, Tomás Lopes Da, Villar-Pique, Anna, Branco, Tiago, Stahlberg, Markus, Camin Dean, Fernández, Claudio, Milosevic, Ira, Outeiro, Tiago
Figure S3. Dyngo blocks whereas PitStop enhances the internalization of aSyn. (A) ICC of H4 cells treated with 1 μM aSyn monomers and with vehicle, PitStop 30 μM or Dyngo 50 μM. Both PitStop and Dyngo are inhibitors of the endocytic processes. (B)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d8f7a041dcbbb2f6e9a02dfb401aae8
Autor:
Masaracchia, Caterina, Hnida, Marilena, Gerhardt, Ellen, Fonseca, Tomás Lopes Da, Villar-Pique, Anna, Branco, Tiago, Stahlberg, Markus, Camin Dean, Fernández, Claudio, Milosevic, Ira, Outeiro, Tiago
Figure S4. Blocking of autophagy inhibits the degradation of aSyn. (A) ICC of H4 cells treated with 1 μM aSyn monomers and with vehicle, Bafilomycin 100 nM (Baf 100 nM), or with Chloroquine 50 μM (Chlq 50 μM). Bafilomycin and chloroquine are inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::108407cdfd70842e7c4fb319d8ab9edc
Autor:
Masaracchia, Caterina, Hnida, Marilena, Gerhardt, Ellen, Fonseca, Tomás Lopes Da, Villar-Pique, Anna, Branco, Tiago, Stahlberg, Markus, Camin Dean, Fernández, Claudio, Milosevic, Ira, Outeiro, Tiago
Figure S2. Membrane binding and internalization of the A11P/V70P aSyn mutant. (A) Membrane binding properties of WT (left) and of A11P/V70P aSyn (right) in the presence of artificial small unilamellar vesicles membranes (SUVs) [1:100 protein:SUVs rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24504f056c85b9e09de031de236ab441
Autor:
Masaracchia, Caterina, Hnida, Marilena, Gerhardt, Ellen, Fonseca, Tomás Lopes Da, Villar-Pique, Anna, Branco, Tiago, Stahlberg, Markus, Camin Dean, Fernández, Claudio, Milosevic, Ira, Outeiro, Tiago
Table S1. Results of the Rab protein screen. Rab-GTPase family members selected in a screen where we assessed alterations in the subcellular distribution of the Rab protein or the colocalization with aSyn in cells treated with aSyn monomers or fibril
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c6d666382be5e9c634f2289da5b2237
Autor:
Masaracchia, Caterina, Hnida, Marilena, Gerhardt, Ellen, TomĂĄs Lopes Da Fonseca, Villar-Pique, Anna, Branco, Tiago, Stahlberg, Markus, Camin Dean, FernĂĄndez, Claudio, Milosevic, Ira, Outeiro, Tiago
Figure S1. Characterization of recombinant aSyn monomers. (A) Fractions collected upon protein separation on Superose 6 10/300 size exclusion column. (B) Chromatogram of recombinant aSyn monomers showing the fractions in which monomeric aSyn was reco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b1311e2fb959c715fb5d3359c7bf37
Autor:
Tolö, Johan, Taschenberger, Grit, Dean, Camin, Bähr, Mathias, Kügler, Sebastian, Leite, Kristian, Stahlberg, Markus A, Spehlbrink, Gesche, Kues, Janina, Munari, Francesca, Capaldi, Stefano, Becker, Stefan, Zweckstetter, Markus
Publikováno v:
Frontiers in Molecular Neuroscience
Frontiers in molecular neuroscience 11, 49 (2018). doi:10.3389/fnmol.2018.00049
Frontiers in molecular neuroscience 11, 49 (2018). doi:10.3389/fnmol.2018.00049
α-Synuclein (α-Syn) is intimately linked to the etiology of Parkinson's Disease, as mutations and even subtle increases in gene dosage result in early onset of the disease. However, how this protein causes neuronal dysfunction and neurodegeneration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::dd1dea7f1cedd13f0bc5c8dd35f2d9a4
https://pubmed.ncbi.nlm.nih.gov/29563864
https://pubmed.ncbi.nlm.nih.gov/29563864
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