Bifunctional degraders of cyclin dependent kinase 9 (CDK9): Probing the relationship between linker length, properties, and selective protein degradation.

Autor: Tokarski RJ 2nd; Division of Medicinal Chemistry & Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, United States., Sharpe CM; Department of Internal Medicine, University of Cincinnati, Cincinnati, OH, 45267, United States., Huntsman AC; Division of Medicinal Chemistry & Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, United States., Mize BK; Division of Medicinal Chemistry & Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, United States., Ayinde OR; Division of Medicinal Chemistry & Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, United States., Stahl EH; The Ohio State University Comprehensive Cancer Center, College of Medicine, The Ohio State University, Columbus, OH, 43210, United States., Lerma JR; Department of Internal Medicine, University of Cincinnati, Cincinnati, OH, 45267, United States., Reed A; CCIC Mass Spectrometry and Proteomics, The Ohio State University, Columbus, OH, 43210, United States., Carmichael B; The Ohio State University Comprehensive Cancer Center, College of Medicine, The Ohio State University, Columbus, OH, 43210, United States., Muthusamy N; The Ohio State University Comprehensive Cancer Center, College of Medicine, The Ohio State University, Columbus, OH, 43210, United States., Byrd JC; Department of Internal Medicine, University of Cincinnati, Cincinnati, OH, 45267, United States; University of Cincinnati Cancer Center, College of Medicine, University of Cincinnati, Cincinnati, OH, 45267, United States., Fuchs JR; Division of Medicinal Chemistry & Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, United States. Electronic address: fuchs.42@osu.edu.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2023 Jun 05; Vol. 254, pp. 115342. Date of Electronic Publication: 2023 Apr 05.