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Utilization of OATP1B Biomarker Coproporphyrin-I to Guide Drug-Drug Interaction Risk Assessment: Evaluation by the Pharmaceutical Industry.

Autor: Kikuchi R; Quantitative, Translational and ADME Sciences, AbbVie Inc., North Chicago, Illinois, USA., Chothe PP; Global Drug Metabolism and Pharmacokinetics, Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts, USA., Chu X; ADME and Discovery Toxicology, Merck & Co., Inc., Rahway, New Jersey, USA., Huth F; PK Sciences, Novartis Pharma AG, Basel, Switzerland., Ishida K; Drug Metabolism, Gilead Sciences Inc., Foster City, California, USA., Ishiguro N; Pharmacokinetics and Non-Clinical Safety Department, Nippon Boehringer Ingelheim Co., Ltd., Kobe, Japan., Jiang R; Drug Metabolism and Pharmacokinetics, Eisai Inc., Cambridge, Massachusetts, USA., Shen H; Departments of Drug Metabolism and Pharmacokinetics, Bristol Myers Squibb Research and Development, Princeton, New Jersey, USA., Stahl SH; CVRM Safety, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK., Varma MVS; Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Pfizer Inc., Groton, Connecticut, USA., Willemin ME; Drug Metabolism and Pharmacokinetics, Janssen Research and Development, a Division of Janssen Pharmaceutica NV, Beerse, Belgium., Morse BL; Department of Drug Disposition, Eli Lilly, Indianapolis, Indiana, USA.

Publikováno v: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2023 Dec; Vol. 114 (6), pp. 1170-1183. Date of Electronic Publication: 2023 Oct 11.

Amplifying the impact of kidney microphysiological systems: predicting renal drug clearance using mechanistic modelling based on reconstructed drug secretion.

Autor: Caetano-Pinto P; ADME Sciences, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom.; Department of Urology, University Medicine Greifswald, Greifswald, Germany., Nordell P; DMPK, Research and Early Development Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Nieskens T; CVRM Safety, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Haughan K; ADME Sciences, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom., Fenner KS; ADME Sciences, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom., Stahl SH; ADME Sciences, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom.; CVRM Safety, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden.

Publikováno v: ALTEX [ALTEX] 2023; Vol. 40 (3), pp. 408-424. Date of Electronic Publication: 2022 Nov 03.

Regulation of Drug Transport Proteins-From Mechanisms to Clinical Impact: A White Paper on Behalf of the International Transporter Consortium.

Autor: Brouwer KLR; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Evers R; Preclinical Sciences and Translational Safety, Johnson & Johnson, Janssen Pharmaceuticals, Spring House, Pennsylvania, USA., Hayden E; Department of Pharmaceutical Sciences, University at Buffalo, Buffalo, New York, USA., Hu S; College of Pharmacy, The Ohio State University, Columbus, Ohio, USA., Li CY; PKDM, Amgen Inc., South San Francisco, California, USA., Meyer Zu Schwabedissen HE; Biopharmacy, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Neuhoff S; Certara UK Ltd., Simcyp Division, Sheffield, UK., Oswald S; Institute of Pharmacology and Toxicology, Rostock University Medical Center, Rostock, Germany., Piquette-Miller M; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada., Saran C; Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Sjöstedt N; Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland., Sprowl JA; Department of Pharmaceutical Sciences, University at Buffalo, Buffalo, New York, USA., Stahl SH; CVRM Safety, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK., Yue W; College of Pharmacy, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.

Publikováno v: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2022 Sep; Vol. 112 (3), pp. 461-484. Date of Electronic Publication: 2022 May 24.

The analysis of acetaminophen (paracetamol) and seven metabolites in rat, pig and human plasma by U(H)PLC-MS.

Autor: Dargue R; Division of Systems Medicine, Department of Metabolism, Digestion & Reproduction, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, UK., Grant I; Division of Systems Medicine, Department of Metabolism, Digestion & Reproduction, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, UK., Nye LC; Division of Systems Medicine, Department of Metabolism, Digestion & Reproduction, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, UK., Nicholls A; GlaxoSmithKline R&D, Park Road, Ware, Hertfordshire SG12 0DP, UK., Dare T; GlaxoSmithKline R&D, Park Road, Ware, Hertfordshire SG12 0DP, UK., Stahl SH; ADME Sciences, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Unit 310 Cambridge Science Park, Milton Road, Cambridge CB4 0WG, UK., Plumb RS; WatersCorporation, Milford, MA 01757, USA., Lee K; Department of Clinical Science & Services, Royal Veterinary College, University of London, Hertfordshire AL9 7TA, UK., Jalan R; UCL Institute for Liver & Digestive Health, Royal Free Hospital, London NW3 2PF, UK., Coen M; Division of Systems Medicine, Department of Metabolism, Digestion & Reproduction, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, UK., Wilson ID; Division of Systems Medicine, Department of Metabolism, Digestion & Reproduction, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, UK.

Publikováno v: Bioanalysis [Bioanalysis] 2020 Apr; Vol. 12 (7), pp. 485-500. Date of Electronic Publication: 2020 Apr 28.