Zobrazeno 1 - 10 of 27 pro vyhledávání: '"Staffan Sundell"'
1
Molecular arrangements in sphingolipids: crystal structure of the ceramide
Autor: Staffan Sundell, Irmin Pascher
Publikováno v: Chemistry and Physics of Lipids. 62:79-86
The conformation and molecular packing of a ceramide, N-(2 d ,3 d -dihydroxyoctadecanoyl)-phytosphingosine , has been determined by single crystal analysis (R = 0.095). The lipid crystallizes in the space group P21 with unit cell dimensions a = 7.23,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60dc1674b10f54cf16a912632a96f467
https://doi.org/10.1016/0009-3084(92)90056-u
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2
A new type of prodrug of catecholamines: An opportunity to improve the treatment of Parkinson's disease
Autor: Bastiaan J, Venhuis, Nienke, Rodenhuis, Håkan V, Wikström, David, Wustrow, Leonard T, Meltzer, Lawrence D, Wise, Stephen J, Johnson, Thomas A, Pugsley, Staffan, Sundell, Durk, Dijkstra
Publikováno v: Journal of Medicinal Chemistry, 45(12), 2349-2351. AMER CHEMICAL SOC
Journal of Medicinal Chemistry, 12(12), 2349-2351. AMER CHEMICAL SOC
After decades of research around dopamine agonists, we have found a promising compound in S-PD148903 that represents a new type of prodrug, which in the rat is bioactivated to the catecholamine S-5,6-diOH-DPAT, known to display mixed dopamine D-1/D-2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82e4828e586a7f361280cdd648b8de1a
https://research.rug.nl/en/publications/232655e4-3806-4f8b-96e2-10cac83f1b48
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3
A proposal for the catalytic mechanism in phospholipase C based on interaction energy and distance geometry calculations
Autor: Sissel Hansen, Staffan Sundell, Edward Hough
Publikováno v: Protein engineering. 7(4)
The non-specific phospholipase C from Bacillus cereus preferentially hydrolyses phosphatidylcholine but is also active against phosphatidylserine, phosphatidylethanolamine and at a much lower level, sphingomyelin. A minimal substrate model containing
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c75c3e118391e2d3fb2f16841ef160bd
https://pubmed.ncbi.nlm.nih.gov/8029214
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4
The effect of hydrogen bonds on the conformation of glycosphingolipids. Methylated and unmethylated cerebroside studied by X-ray single crystal analysis and model calculations
Autor: Per-Geor Nyholm, Irmin Pascher, Staffan Sundell
Publikováno v: Chemistry and physics of lipids. 52(1)
The conformation and molecular packing of permethylated beta-D-galactosyl-N-octadecanoyl-D-spingosine (cerebroside) was determined by X-ray single crystal analysis at 185 K (R = 0.16). The lipid crystallizes in the orthorhombic space group P2(1)2(1)2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::954bcde1681b34f0547d348afe651147
https://pubmed.ncbi.nlm.nih.gov/2306786
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9
Conformation of phospholipids
Autor: Irmin Pascher, Helmut Hauser, Staffan Sundell
Publikováno v: Journal of Molecular Biology. 137:249-264
The conformation and molecular packing of deoxylysophosphatidylcholine monohydrate (3-dodecanoyl-propandiol-1-phosphorylcholine · H2O) has been determined by single-crystal analysis. The lipid crystallizes in the monoclinic space group P2 1 c with u
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::777559994102089612c4ca13ce681072
https://doi.org/10.1016/0022-2836(80)90315-0
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