Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Staffan Cullheim"'
Autor:
Alexander Berg, Johan Zelano, Marcela Pekna, Ulrika Wilhelmsson, Milos Pekny, Staffan Cullheim
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79395 (2013)
Peripheral axotomy of motoneurons triggers Wallerian degeneration of injured axons distal to the lesion, followed by axon regeneration. Centrally, axotomy induces loss of synapses (synaptic stripping) from the surface of lesioned motoneurons in the s
Externí odkaz:
https://doaj.org/article/9e4368efa2ac454e93727fafd3d8bd7a
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59647 (2013)
Synapse elimination in the adult central nervous system can be modelled by axotomy of spinal motoneurons which triggers removal of synapses from the cell surface of lesioned motoneurons by processes that remain elusive. Proposed candidate mechanisms
Externí odkaz:
https://doaj.org/article/c8864efd423c478fb4b089225dc7bb52
Autor:
Staffan Cullheim, Thomas Carlstedt, Wilhelm Wallquist, Tomas Lindholm, Henrik Hammarberg, Mårten Risling, Mattias K. Sköld
Publikováno v:
Frontiers in Neurology
Dorsal root injury is a situation not expected to be followed by a strong regenerative growth, or growth of the injured axon into the central nervous system of the spinal cord, if the central axon of the dorsal root is injured but of strong regenerat
Autor:
Fredrik Piehl, Margarita Diez, Taher Darreh-Shori, Johan Zelano, Alexander Berg, Mikael Ström, Swetha Vijayaraghavan, Rickard P. F. Lindblom, Xing-Mei Zhang, Cecilia A. Dominguez, Karin Harnesk, Norbert Hubner, Faiez Al Nimer, Matthias Heinig, Staffan Cullheim, Shahin Aeinehband
Publikováno v:
The Journal of Immunology
The complement system is activated in a wide spectrum of CNS diseases and is suggested to play a role in degenerative phenomena such as elimination of synaptic terminals. Still, little is known of mechanisms regulating complement activation in the CN
Publikováno v:
Molecular and Cellular Neuroscience. 56:96-101
The successful outcome of peripheral neuronal regeneration is attributed both to the growth permissive milieu and the intrinsic ability of the neuron to initiate appropriate cellular responses such as changes in gene expression and cytoskeletal rearr
Autor:
Nils-Göran Larsson, Fredrik H. Sterky, Arnaud Mourier, Seungmin Lee, Lars Olson, Staffan Cullheim, Mügen Terzioglu
Publikováno v:
Hum Mol Genet
Mitochondrial dysfunction is implicated in aging and degenerative disorders such as Parkinson's disease (PD). Continuous fission and fusion of mitochondria shapes their morphology and is essential to maintain oxidative phosphorylation. Loss-of-functi
Publikováno v:
NeuroReport. 21:782-785
Netrin G-2 ligand (NGL-2) and synaptic adhesion like molecules induce synapses in vitro. We investigated the expression of these molecules in a model of CNS synaptic detachment and restoration in vivo. After axotomy of spinal motoneurons, synapses ar
Publikováno v:
Brain Research Reviews. 57:265-269
An axon lesion to a bulbar or spinal motoneuron is followed by a typical retrograde response at the cell body level, including the removal or 'stripping' of synapses from the perikaryon and dendrites of affected cells. Both activated microglia and as
Publikováno v:
Synapse. 62:137-148
The success of axonal regeneration has been attributed to a co-operation between the severed neurons and the surrounding environment, including non-neuronal cells and the extracellular matrix. Important differences regarding the regeneration potentia
Autor:
Rickard P. F. Lindblom, Cecilia A. Dominguez, Staffan Cullheim, Bo Nilsson, Margarita Diez, Faiez Al Nimer, Johan Zelano, Fredrik Piehl, Shahin Aeinehband, Karin Harnesk, Alexander Berg, Nada Abdelmagid, Matthias Heinig, Mikael Ström, Kristina Nilsson Ekdahl, Norbert Hubner
Publikováno v:
Journal of Neuroinflammation
Background Activation of the complement system has been implicated in both acute and chronic states of neurodegeneration. However, a detailed understanding of this complex network of interacting components is still lacking. Methods Large-scale global