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Autor:
Harold I. Saavedra, Philipp Kaldis, Hiroaki Kiyokawa, Mary K. Harrison, Xiangbin Zeng, Arsene M. Adon, Stacy Sannem
Publikováno v:
Molecular and cellular biology. 40(23)
The two mitotic centrosomes direct spindle bipolarity to maintain euploidy. Centrosome amplification—the acquisition of ≥3 centrosomes—generates multipolar mitoses, aneuploidy, and chromosome instability to promote cancer biogenesis. While much