Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Stacy L. Throm"'
Autor:
Clinton F. Stewart, Burgess B. Freeman, Stacy L. Throm, K. Elaine Harstead, David M. Loeb, Jennifer Reikes Willert, Bhaskar Rao, Michael Neel, Victor M. Santana, Jianrong Wu, Shenghua Mao, Najat C. Daw, Fariba Navid, David C. Turner
Purpose: To describe sources of interindividual variability in bevacizumab disposition in pediatric patients and explore associations among bevacizumab pharmacokinetics and clinical wound healing outcomes.Experimental Design: Before tumor resection,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c735d08d71518fd443f7e25a1e9a5a5e
https://doi.org/10.1158/1078-0432.c.6521471.v1
https://doi.org/10.1158/1078-0432.c.6521471.v1
Autor:
Clinton F. Stewart, Burgess B. Freeman, Stacy L. Throm, K. Elaine Harstead, David M. Loeb, Jennifer Reikes Willert, Bhaskar Rao, Michael Neel, Victor M. Santana, Jianrong Wu, Shenghua Mao, Najat C. Daw, Fariba Navid, David C. Turner
PDF file - 200K, Supplementary Table 1. Comparison of predictive performance for model parameterizations A, (B), and C (with IBW covariate) Supplemental Figure 1. The base structural bevacizumab model consisted of a two compartment model parameterize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b2018329160909b9d070253b4a6cefe
https://doi.org/10.1158/1078-0432.22448723
https://doi.org/10.1158/1078-0432.22448723
Autor:
Vinay M. Daryani, K. Elaine Harstead, Yogesh T. Patel, Clinton F. Stewart, Megan O. Jacus, Stacy L. Throm
Publikováno v:
Clinical Pharmacokinetics. 55:297-311
Despite significant improvement in outcomes for patients with hematologic malignancies and solid tumors over the past 10 years, patients with primary or metastatic brain tumors continue to have a poor prognosis. A primary reason for this is the inabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0efa15e37fb45c9a86b3ec0f391ea9e4
https://doi.org/10.1007/s40262-015-0319-6
https://doi.org/10.1007/s40262-015-0319-6
Autor:
Marie Morfouace, Yogesh T. Patel, David C. Turner, Clinton F. Stewart, Nidal Boulos, Burgess B. Freeman, Megan O. Jacus, Stacy L. Throm
Publikováno v:
European Journal of Pharmaceutical Sciences. 57:41-47
The treatment of children with primary central nervous system (CNS) tumors continues to be a challenge despite recent advances in technology and diagnostics. In this overview, we describe our approach for identifying and evaluating active anticancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b42ed4d62f7be504d35b81ed44480280
https://doi.org/10.1016/j.ejps.2013.11.010
https://doi.org/10.1016/j.ejps.2013.11.010
Autor:
Shenghua Mao, Fariba Navid, Jennifer Willert, Najat C. Daw, Stacy L. Throm, Victor M. Santana, Bhaskar N. Rao, K. Elaine Harstead, Michael D. Neel, Clinton F. Stewart, David C. Turner, Burgess B. Freeman, David M. Loeb, Jianrong Wu
Publikováno v:
Clinical Cancer Research. 20:2783-2792
Purpose: To describe sources of interindividual variability in bevacizumab disposition in pediatric patients and explore associations among bevacizumab pharmacokinetics and clinical wound healing outcomes. Experimental Design: Before tumor resection,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d674fcaffd66c176494b8138e31e695
https://doi.org/10.1158/1078-0432.ccr-13-2364
https://doi.org/10.1158/1078-0432.ccr-13-2364
Autor:
Michael S, Roberts, David C, Turner, Thandranese S, Owens, Abhijit, Ramachandran, Cynthia, Wetmore, Stacy L, Throm, Clinton F, Stewart
Publikováno v:
Journal of Chromatography B. 929:1-5
A LC-ESI-MS/MS method for the determination of crenolanib (CP-868,596) in human serum was developed and validated employing d4-CP-868,596 as an internal standard (ISTD). In addition to human serum, the method was also partially validated for crenolan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c2586f61565b574effda1d6caf28348
https://doi.org/10.1016/j.jchromb.2013.04.002
https://doi.org/10.1016/j.jchromb.2013.04.002
Autor:
Angel M. Carcaboso, Lionel M.L. Chow, Clinton F. Stewart, Stacy L. Throm, Ziwei M. Zhang, Mohamed A. Elmeliegy, Suzanne J. Baker, Fan Wang, Christopher Calabrese
Publikováno v:
Journal of Pharmaceutical Sciences. 100:4210-4214
Cerebral microdialysis is used to study anticancer drug penetration in the central nervous system (CNS) and brain tumors in animal models. Genetically engineered murine models (GEMMs) have been recently used to study many aspects of CNS tumors since
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aa8e7ba40218a32204066aee7239989
https://doi.org/10.1002/jps.22723
https://doi.org/10.1002/jps.22723
Autor:
Jun Shen, Vishal S. Narang, Clinton F. Stewart, Christopher M. Waters, Narendra Kumar, Charles H. Fraga, Stacy L. Throm
Publikováno v:
American Journal of Physiology-Cell Physiology. 295:C440-C450
Brain edema is an important factor leading to morbidity and mortality associated with primary brain tumors. Dexamethasone, a synthetic glucocorticoid, is routinely prescribed with antineoplastic agents to alleviate pain associated with chemotherapy a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae3b115a8772c6a2b85f06e18017eaa3
https://doi.org/10.1152/ajpcell.00491.2007
https://doi.org/10.1152/ajpcell.00491.2007
Autor:
Charles H. Fraga, Tiebin Liu, Lisa M. McGregor, Stacy L. Throm, Clinton F. Stewart, Catherine A. Billups, Carlos Rodriguez-Galindo, Thandranese S. Owens, Amar Gajjar, Wayne L. Furman, Melinda A. O'Shaughnessy, John C. Panetta
Publikováno v:
Journal of Clinical Oncology. 25:2594-2600
PurposeTo study the association between UDP-glucuronosyltransferase 1A1 (UGT1A1) genotypes and severe toxicity as well as irinotecan disposition in pediatric patients with solid tumors receiving low-dose, protracted irinotecan (15 to 75 mg/m2daily fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34340aef3ee6cfe46c00ee586bba3b8c
https://doi.org/10.1200/jco.2006.10.2301
https://doi.org/10.1200/jco.2006.10.2301
Autor:
Megan O. Jacus, Abigail D. Davis, Stacy L. Throm, Burgess B. Freeman, Kumarasamypet M. Mohankumar, Clinton F. Stewart, Jason Dapper, Pradeep K. Vuppala, Nidal Boulos, Yogesh T. Patel, Richard J. Gilbertson
Clofarabine, a deoxyadenosine analog, was an active anticancer drug in our in vitro high-throughput screening against mouse ependymoma neurospheres. To characterize the clofarabine disposition in mice for further preclinical efficacy studies, we eval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e8d9f619432e2fc9a300dec9774f732
https://europepmc.org/articles/PMC4420645/
https://europepmc.org/articles/PMC4420645/