Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Stacy K. Thomas"'
Autor:
Il-Kyu Kim, Mark S. Diamond, Salina Yuan, Samantha B. Kemp, Benjamin M. Kahn, Qinglan Li, Jeffrey H. Lin, Jinyang Li, Robert J. Norgard, Stacy K. Thomas, Maria Merolle, Takeshi Katsuda, John W. Tobias, Timour Baslan, Katerina Politi, Robert H. Vonderheide, Ben Z. Stanger
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Acquired resistance to immunotherapy remains a critical yet incompletely understood biological mechanism. Here, using a mouse model of pancreatic ductal adenocarcinoma (PDAC) to study tumor relapse following immunotherapy-induced responses,
Externí odkaz:
https://doaj.org/article/96e408eb89f447649478a14b903b0f6a
Autor:
Stacy K. Thomas, Max M. Wattenberg, Shaanti Choi-Bose, Mark Uhlik, Ben Harrison, Heather Coho, Christopher R. Cassella, Meredith L. Stone, Dhruv Patel, Kelly Markowitz, Devora Delman, Michael Chisamore, Jeremy Drees, Nandita Bose, Gregory L. Beatty
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Although macrophages contribute to cancer cell dissemination, immune evasion, and metastatic outgrowth, they have also been reported to coordinate tumor-specific immune responses. We therefore hypothesized that macrophage polarization could
Externí odkaz:
https://doaj.org/article/83508be0427a42c987caca447a63c531
Publikováno v:
EBioMedicine, Vol 53, Iss , Pp - (2020)
Pancreatic ductal adenocarcinoma (PDAC) shows remarkable propensity to metastasize. This predilection to escape from the primary tumor is driven by paracrine and autocrine mechanisms that guide cancer cells through a multi-step process concluding wit
Externí odkaz:
https://doaj.org/article/1a32e15c2a664f4f8d4d9e2144eb9916
Autor:
Anthony C. Cruz, Madhu Ramaswamy, Claudia Ouyang, Christopher A. Klebanoff, Prabuddha Sengupta, Tori N. Yamamoto, Françoise Meylan, Stacy K. Thomas, Nathan Richoz, Robert Eil, Susan Price, Rafael Casellas, V. Koneti Rao, Jennifer Lippincott-Schwartz, Nicholas P. Restifo, Richard M. Siegel
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Fas drives apoptosis and mutations in this receptor can cause autoimmunity through failure of cell death. Here, the authors uselpr/lprmice with palmitoylation-defective mutant Fas to provide evidence that Fas might limit spontaneous autoimmunity thro
Externí odkaz:
https://doaj.org/article/cc383b006c164d3693b4b809cca1c231
Autor:
Irfan A. Asangani, Jeffrey H. Lin, Yogev Sela, Benjamin A. Garcia, Emma M. Miller, Stacy K. Thomas, Salina Yuan, Jinyang Li, Natarajan V. Bhanu, Ben Z. Stanger, Ramakrishnan Natesan, Taiji Yamazoe, Junwei Shi, Jacqueline B Plesset, Scott W. Lowe, Allyson J. Merrell, Francisco J. Sánchez-Rivera, Yanqing Jiang
Publikováno v:
Cancer Discov
Epithelial plasticity, reversible modulation of a cell's epithelial and mesenchymal features, is associated with tumor metastasis and chemoresistance, leading causes of cancer mortality. Although different master transcription factors and epigenetic
Autor:
Stacy K. Thomas, Shaanti Choi-Bose, Heather Coho, Christopher Casella, Meredith L. Stone, Max M. Wattenberg, Gregory L. Beatty
Publikováno v:
Cancer Research. 82:5633-5633
Introduction: For most patients with pancreatic ductal adenocarcinoma (PDAC), metastatic disease is the main cause of mortality with the liver being the most common site of metastasis. In the liver, macrophages are the most abundant immune cell subse
Autor:
Dong Xin, Ailing Ji, Austin L. Chien, Meredith L. Stone, Kathleen Graham, Maria C. de Beer, Ramesh K. Ramanathan, Jae W. Lee, Mitesh J. Borad, Taylor A. Black, Krishna S. Majmundar, Mark H. O'Hara, Devora Delman, Stephanie S. Yee, Stacy K. Thomas, Mingming Gao, Joey H. Li, Abraham Shaked, Paige M. Porrett, Dexi Liu, Xia Hua, Erica L. Carpenter, Whitney L. Gladney, Gregory L. Beatty, Frederick C. de Beer, Charu Aggarwal, Chad A. Komar, Jeffrey C. Thompson, Nancy R. Webb
Publikováno v:
Nature
The liver is the most common site of metastatic disease1. Although this metastatic tropism may reflect the mechanical trapping of circulating tumour cells, liver metastasis is also dependent, at least in part, on the formation of a 'pro-metastatic' n
Autor:
Stacy K. Thomas, Gregory L Beatty
Publikováno v:
The Journal of Immunology. 208:61.04-61.04
Metastasis is the main cause of morbidity and mortality in patients with cancer. In pancreatic ductal adenocarcinoma (PDA), the liver is the most common site of metastasis. During PDA progression, the liver microenvironment becomes altered to support
Autor:
Anthony C. Cruz, Prabuddha Sengupta, Qingshan Fu, Hao Wu, Shuqing Wang, Richard M. Siegel, Stacy K. Thomas, Tian-Min Fu, James J. Chou
Publikováno v:
Molecular Cell. 61:602-613
Fas (CD95, Apo-1, TNFRSF6) is a prototypical apoptosis-inducing death receptor in the tumor necrosis factor receptor (TNFR) superfamily. While the extracellular domains of TNFRs form trimeric complexes with their ligands and the intracellular domains
Autor:
Natarajan V. Bhanu, Irfan A. Asangani, Jeffrey H. Lin, Ben A. Garcia, Allyson J. Merrell, Francisco J. Sánchez-Rivera, Junwei Shi, Stacy K. Thomas, Salina Yuan, Jinyang Li, Ben Z. Stanger, Taiji Yamazoe, Scott W. Lowe, Ramakrishnan Natesan
Publikováno v:
Cancer Research. 79:A59-A59
Metastasis and chemoresistance, the most lethal consequences of cancer progression, are associated with a form of cellular plasticity known as the epithelial-to-mesenchymal transition (EMT). During this process, epithelial cells disassemble their int