Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Stacy A. Maitland"'
Autor:
Khaled Essawi, Waleed Hakami, Muhammad Behroz Naeem Khan, Reid Martin, Jing Zeng, Rebecca Chu, Naoya Uchida, Aylin C. Bonifacino, Allen E. Krouse, Nathaniel S. Linde, Robert E. Donahue, Gerd A. Blobel, Ulrike Gerdemann, Leslie S. Kean, Stacy A. Maitland, Scot A. Wolfe, Jean-Yves Metais, Stephen Gottschalk, Daniel E. Bauer, John F. Tisdale, Selami Demirci
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 483-493 (2023)
CRISPR-Cas9-based therapeutic genome editing approaches hold promise to cure a variety of human diseases. Recent findings demonstrate pre-existing immunity for the commonly used Cas orthologs from Streptococcus pyogenes (SpCas9) and Staphylococcus au
Externí odkaz:
https://doaj.org/article/186bb2a612c54f99a14f07e9473590ec
Autor:
Emmanouela Tsagkaraki, Adilson Guilherme, Sarah M. Nicoloro, Mark Kelly, Lawrence M. Lifshitz, Hui Wang, Kyounghee Min, Leslie A. Rowland, Kaltinaitis B. Santos, Nicole Wetoska, Randall H. Friedline, Stacy A. Maitland, Min Chen, Lee S. Weinstein, Scot A. Wolfe, Jason K. Kim, Michael P. Czech
Publikováno v:
Molecular Metabolism, Vol 76, Iss , Pp 101780- (2023)
Objectives: Nuclear receptor interacting protein 1 (NRIP1) suppresses energy expenditure via repression of nuclear receptors, and its depletion markedly elevates uncoupled respiration in mouse and human adipocytes. We tested whether NRIP1 deficient a
Externí odkaz:
https://doaj.org/article/8509853fb6d444bb83dafa8e5ebf8337
Akademický článek
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Autor:
Karthikeyan Ponnienselvan, Pengpeng Liu, Thomas Nyalile, Sarah Oikemus, Stacy A Maitland, Nathan D Lawson, Jeremy Luban, Scot A Wolfe
Publikováno v:
Nucleic Acids Research.
Prime editing systems have enabled the incorporation of precise edits within a genome without introducing double strand breaks. Previous studies defined an optimal primer binding site (PBS) length for the pegRNA of ∼13 nucleotides depending on the
Autor:
Jing Zeng, My Anh Nguyen, Pengpeng Liu, Lucas Ferreira da Silva, Linda Y. Lin, David G. Justus, Karl Petri, Kendell Clement, Shaina N. Porter, Archana Verma, Nola R. Neri, Tolulope Rosanwo, Marioara-Felicia Ciuculescu, Daniela Abriss, Esther Mintzer, Stacy A. Maitland, Selami Demirci, John F. Tisdale, David A. Williams, Lihua Julie Zhu, Shondra M. Pruett-Miller, Luca Pinello, J. Keith Joung, Vikram Pattanayak, John P. Manis, Myriam Armant, Danilo Pellin, Christian Brendel, Scot A. Wolfe, Daniel E. Bauer
Publikováno v:
bioRxiv
SUMMARYGene editing theBCL11Aerythroid enhancer is a validated approach to fetal hemoglobin (HbF) induction for β-hemoglobinopathy therapy, though heterogeneity in edit allele distribution and HbF response may impact its safety and efficacy. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250458872ad1c0dd4644117680ac337a
https://doi.org/10.1101/2023.05.27.542323
https://doi.org/10.1101/2023.05.27.542323
Autor:
Kevin Luk, Pengpeng Liu, Jing Zeng, Yetao Wang, Stacy A. Maitland, Feston Idrizi, Karthikeyan Ponnienselvan, Lihua Julie Zhu, Jeremy Luban, Daniel E. Bauer, Scot A. Wolfe
Publikováno v:
GEN Biotechnology. 1:271-284
Autor:
Samuele Cancellieri, Jing Zeng, Linda Yingqi Lin, Manuel Tognon, My Anh Nguyen, Jiecong Lin, Nicola Bombieri, Stacy A. Maitland, Marioara-Felicia Ciuculescu, Varun Katta, Shengdar Q. Tsai, Myriam Armant, Scot A. Wolfe, Rosalba Giugno, Daniel E. Bauer, Luca Pinello
Publikováno v:
Nat Genet
CRISPR gene editing holds great promise to modify DNA sequences in somatic cells to treat disease. However, standard computational and biochemical methods to predict off-target potential focus on reference genomes. We developed an efficient tool call
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a6955ae43d77107bdfe1de09e8c63a
https://hdl.handle.net/11562/1080767
https://hdl.handle.net/11562/1080767
Autor:
Rahul Palchaudhuri, Selami Demirci, Leanne Lanieri, Sharon L. Hyzy, Anjali Bhat, Tahirih L. Lamothe, Katelyn Hammond, Tiffany Tate, Zhuyan Guo, Eric Cheah, Xin Qiao, Jing Zeng, Stacy A. Maitland, Bindu Bennet, Kirk Bertelsen, Robert E. Donahue, Scot A. Wolfe, Daniel E. Bauer, John F. Tisdale, Lisa M. Olson
Publikováno v:
Transplantation and Cellular Therapy. 29:S165-S166
Autor:
Jing Zeng, My Anh Nguyen, Marioara-Felicia Ciuculescu, Esther Mintzer, Pengpeng Liu, Linda Yingqi Lin, Tolulope O Rosanwo, Archana Verma, Nola Neri, Stacy A. Maitland, Alden Richter, David G. Justus, Kendell Clement, Christian Brendel, Luca Pinello, John P Manis, Myriam Armant, Scot A. Wolfe, Daniel E. Bauer
Publikováno v:
Blood. 140:10671-10672
Autor:
Kevin Luk, Pengpeng Liu, Jing Zeng, Yetao Wang, Stacy A. Maitland, Feston Idrizi, Karthikeyan Ponnienselvan, Lihua Julie Zhu, Jeremy Luban, Daniel E. Bauer, Scot A. Wolfe
Type V CRISPR–Cas12a systems are an attractive alternative nuclease platform for specific genome editing applications. However, previous studies demonstrate that there is a gap in overall activity between Cas12a and Cas9 in primary cells. Here we d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f20817b7c771b82a667424c37b56a513
https://doi.org/10.1101/2022.02.01.478672
https://doi.org/10.1101/2022.02.01.478672