Výsledky vyhledávání - "Stacy Markison"

Akademický článek

Toxicological evaluation of a novel umami flavour compound: 2-(((3-(2,3-Dimethoxyphenyl)-1H-1,2,4-triazol-5-yl)thio)methyl)pyridine

Autor: Donald S. Karanewsky, Amy J. Arthur, Hanghui Liu, Bert Chi, Lily Ida, Stacy Markison

Publikováno v: Toxicology Reports, Vol 3, Iss , Pp 501-512 (2016)

A toxicological evaluation of a umami flavour compound, 2-(((3-(2,3-dimethoxyphenyl)-1H-1,2,4-triazol-5-yl)thio)methyl)pyridine (S3643; CAS 902136-79-2), was completed for the purpose of assessing its safety for use in food and beverage applications.

Externí odkaz: https://doaj.org/article/dc58427212f94ef9866f9ec8d04ef7b6

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Akademický článek

Toxicological evaluation of two novel bitter modifying flavour compounds: 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-1-(3-hydroxybenzyl)imidazolidine-2,4-dione and 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-1-(3-hydroxybenzyl)-5,5-dimethylimidazolidine-2,4-dione

Autor: Donald S. Karanewsky, Amy J. Arthur, Hanghui Liu, Bert Chi, Lily Ida, Stacy Markison

Publikováno v: Toxicology Reports, Vol 3, Iss , Pp 310-327 (2016)

A toxicological evaluation of two novel bitter modifying flavour compounds, 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-1-(3-hydroxybenzyl)imidazolidine-2,4-dione (S6821, CAS 1119831-25-2) and 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H

Externí odkaz: https://doaj.org/article/909c54b40a4347f3a82d42ea4319a457

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Akademický článek

Toxicological evaluation of a novel cooling compound: 2-(4-methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(2-thienylmethyl)acetamide

Autor: Donald S. Karanewsky, Amy J. Arthur, Hanghui Liu, Bert Chi, Stacy Markison

Publikováno v: Toxicology Reports, Vol 2, Iss C, Pp 1291-1309 (2015)

A toxicological evaluation of a novel cooling agent, 2-(4-methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(2-thienylmethyl) acetamide (S2227; CAS 1374760-95-8), was completed for the purpose of assessing its safety for use in food and beverage applications. S22

Externí odkaz: https://doaj.org/article/29af3a50ab834f12a39262c7460ad779

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Akademický článek

Toxicological evaluation of the flavour ingredient 4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylic acid

Autor: Amy J. Arthur, Donald S. Karanewsky, Hanghui Liu, Bert Chi, Stacy Markison

Publikováno v: Toxicology Reports, Vol 2, Iss C, Pp 1255-1264 (2015)

A toxicological evaluation of 4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylic acid(S9632; CAS 1359963-68-0), a flavour with modifying properties,was completed for the purpose of assessing its safety for use in

Externí odkaz: https://doaj.org/article/de7f947cf602457a920213136f2b4a94

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LBSAT142 Discovery And Characterization Of A Potent And Orally Bioavailable Parathyroid Hormone Receptor Type-1 (PTHR1) Antagonist For The Treatment Of Hypercalcemia

Autor: Elizabeth Rico-Bautista, Joseph Pontillo, Shimiao Wang, Agnes S Antwan, Pablo Arroyo, Beth Fleck, Melissa A Fowler, Greg Reinhart, Michael A Johns, Ana K Kusnetzow, Yun Fei Zhu, Stacy Markison, Stephen F Betz

Publikováno v: Journal of the Endocrine Society. 6:A151-A152

Hypercalcemia is a common disorder defined as a serum calcium concentration higher than the normal range of 8.5 - 10.5 mg/dL. The most common causes of hypercalcemia are over-secretion of parathyroid hormone (PTH) from one or more enlarged parathyroi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42ed107f1ec34d893aef4810a6caa3af
https://doi.org/10.1210/jendso/bvac150.309

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Discovery of 4-(3-aminopyrrolidinyl)-3-aryl-5-(benzimidazol-2-yl)-pyridines as potent and selective SST5 agonists for the treatment of congenital hyperinsulinism

Autor: Jian Zhao, Shimiao Wang, Sun Hee Kim, Sangdon Han, Elizabeth Rico-Bautista, Emmanuel Sturchler, Julie Nguyen, Hannah Tan, Christine Staley, Ana Karin Kusnetzow, Stephen F. Betz, Michael Johns, Lance Goulet, Rosa Luo, Melissa Fowler, Jon Athanacio, Stacy Markison, R. Scott Struthers, Yunfei Zhu

Publikováno v: Bioorganicmedicinal chemistry letters. 71

SST5 receptor activation potently inhibits insulin secretion from pancreatic β-cells, and an orally available nonpeptide selective SST5 agonist may be used to effectively manage the blood glucose levels of congenital HI patients to avoid severe hypo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08412728bd9e34f60beabf7d56a84d5c
https://pubmed.ncbi.nlm.nih.gov/35605837

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Paltusotine, a novel oral once-daily nonpeptide SST2 receptor agonist, suppresses GH and IGF-1 in healthy volunteers

Autor: Ajay Madan, Stacy Markison, Stephen F. Betz, Alan Krasner, Rosa Luo, Theresa Jochelson, Jason Lickliter, R. Scott Struthers

Publikováno v: Pituitary. 25(2)

Purpose Evaluate the pharmacodynamics, pharmacokinetics, and safety of paltusotine, an orally bioavailable, nonpeptide, somatostatin receptor subtype 2 (SST2) agonist being developed for the treatment of acromegaly and neuroendocrine tumors. Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b20574ba53c22e9b6dc20890c869cb90
https://pubmed.ncbi.nlm.nih.gov/35000098

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