Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Stacie E. Hughes"'
Publikováno v:
PLoS Genetics, Vol 15, Iss 5, p e1008161 (2019)
During early meiotic prophase, homologous chromosomes are connected along their entire lengths by a proteinaceous tripartite structure known as the synaptonemal complex (SC). Although the components that comprise the SC are predominantly studied in t
Externí odkaz:
https://doaj.org/article/506eb29bc2d94b8ca89224c89a8d63bf
Autor:
R. Scott Hawley, Stacie E. Hughes
Publikováno v:
Trends in Genetics. 36:833-844
The synaptonemal complex (SC), a highly conserved structure built between homologous meiotic chromosomes, is required for crossover formation and ensuring proper chromosome segregation. In many organisms, SC components can also form alternative struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8703a838a835ff4d24368a624a8f9789
https://doi.org/10.1016/j.tig.2020.07.007
https://doi.org/10.1016/j.tig.2020.07.007
Publikováno v:
Curr Biol
During meiosis, the maintenance of genome integrity is critical for generating viable haploid gametes.(1) In meiotic prophase I, double-strand DNA breaks (DSBs) are induced and a subset of these DSBs are repaired as interhomolog crossovers to ensure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e67711ff2cad4342944f48bbd7c881f
https://doi.org/10.1016/j.cub.2021.03.093
https://doi.org/10.1016/j.cub.2021.03.093
Autor:
Stacie E Hughes, R Scott Hawley
Publikováno v:
PLoS Genetics, Vol 10, Iss 10, p e1004650 (2014)
Heterochromatic homology ensures the segregation of achiasmate chromosomes during meiosis I in Drosophila melanogaster females, perhaps as a consequence of the heterochromatic threads that connect achiasmate homologs during prometaphase I. Here, we a
Externí odkaz:
https://doaj.org/article/7579508782cc4eefa407dff94a502d41
Autor:
Stacie E. Hughes, R. Scott Hawley
Publikováno v:
Curr Biol
Interhomolog crossovers (COs) are a prerequisite for achieving accurate chromosome segregation during meiosis [1, 2]. COs are not randomly positioned, occurring at distinct genomic intervals during meiosis in all species examined [3, 4, 5, 6, 7, 8, 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b55f249b765c71bca62811299bfcec9a
https://pubmed.ncbi.nlm.nih.gov/32142707
https://pubmed.ncbi.nlm.nih.gov/32142707
Publikováno v:
Genetics. 208:875-908
A century of genetic studies of the meiotic process in Drosophila melanogaster females has been greatly augmented by both modern molecular biology and major advances in cytology. These approaches, and the findings they have allowed, are the subject o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd615b47b9129946a1cd817738223c17
https://doi.org/10.1534/genetics.117.300081
https://doi.org/10.1534/genetics.117.300081
Autor:
Stacie E Hughes, J Scott Beeler, Angela Seat, Brian D Slaughter, Jay R Unruh, Elisabeth Bauerly, Heinrich J G Matthies, R Scott Hawley
Publikováno v:
PLoS Genetics, Vol 7, Iss 8, p e1002209 (2011)
In many animal species the meiosis I spindle in oocytes is anastral and lacks centrosomes. Previous studies of Drosophila oocytes failed to detect the native form of the germline-specific γ-tubulin (γTub37C) in meiosis I spindles, and genetic studi
Externí odkaz:
https://doaj.org/article/1c03214b6e0c4e239aed52de37ca6173
Autor:
Stacie E Hughes, R Scott Hawley
Publikováno v:
PLoS Biology, Vol 7, Iss 10, p e1000233 (2009)
Externí odkaz:
https://doaj.org/article/06781381533a468e85644285da73ce33
Heterochromatic threads connect oscillating chromosomes during prometaphase I in Drosophila oocytes.
Autor:
Stacie E Hughes, William D Gilliland, Jeffrey L Cotitta, Satomi Takeo, Kim A Collins, R Scott Hawley
Publikováno v:
PLoS Genetics, Vol 5, Iss 1, p e1000348 (2009)
In Drosophila oocytes achiasmate homologs are faithfully segregated to opposite poles at meiosis I via a process referred to as achiasmate homologous segregation. We observed that achiasmate homologs display dynamic movements on the meiotic spindle d
Externí odkaz:
https://doaj.org/article/45b717a309ca451088f52f07a957f803
Autor:
Youbin Xiang, Satomi Takeo, Laurence Florens, Stacie E Hughes, Li-Jun Huo, William D Gilliland, Selene K Swanson, Kathy Teeter, Joel W Schwartz, Michael P Washburn, Sue L Jaspersen, R Scott Hawley
Publikováno v:
PLoS Biology, Vol 5, Iss 12, p e323 (2007)
Many meiotic systems in female animals include a lengthy arrest in G2 that separates the end of pachytene from nuclear envelope breakdown (NEB). However, the mechanisms by which a meiotic cell can arrest for long periods of time (decades in human fem
Externí odkaz:
https://doaj.org/article/72c7a1a0309a4c889f589f837e437108