Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Stacie Clark"'
Autor:
Derek Thibault, Paul A. Jensen, Stephen Wood, Christine Qabar, Stacie Clark, Mara G. Shainheit, Ralph R. Isberg, Tim van Opijnen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Culturing transposon-mutant libraries in pools can mask complex phenotypes. Here the authors present microfluidics mediated droplet Tn-Seq, which encapsulates individual mutants, promotes isolated growth and enables cell-cell interaction analyses.
Externí odkaz:
https://doaj.org/article/ea4ad1594e3847579e9ba764776164b2
Publikováno v:
PLoS Pathogens, Vol 12, Iss 9, p e1005898 (2016)
All three pathogenic Yersinia species share a conserved virulence plasmid that encodes a Type 3 Secretion System (T3SS) and its associated effector proteins. During mammalian infection, these effectors are injected into innate immune cells, where the
Externí odkaz:
https://doaj.org/article/5d2e6df15ad04fef86f9b25e2f8bd00b
Autor:
Elsa N Bou Ghanem, Stacie Clark, Sara E Roggensack, Sally R McIver, Pilar Alcaide, Philip G Haydon, John M Leong
Publikováno v:
PLoS Pathogens, Vol 11, Iss 8, p e1005126 (2015)
An important determinant of disease following Streptococcus pneumoniae (pneumococcus) lung infection is pulmonary inflammation mediated by polymorphonuclear leukocytes (PMNs). We found that upon intratracheal challenge of mice, recruitment of PMNs in
Externí odkaz:
https://doaj.org/article/71c29e14cfd1463691a188f331f27d72
Autor:
Stacie Clark, Tim van Opijnen, Kimberly M. Davis, Derek Thibault, Ralph R. Isberg, Lauren M Shull, Emily Aunins
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Within deep tissue sites, extracellular bacterial pathogens often replicate in clusters that are surrounded by immune cells. Disease is modulated by interbacterial interactions as well as bacterial-host cell interactions resulting in microbial growth
Autor:
Ralph R. Isberg, Tim van Opijnen, Stacie Clark, Derek Thibault, Kimberly M. Davis, Emily Aunins, Lauren M Shull
Within deep tissue sites, extracellular bacterial pathogens often replicate in clusters that are surrounded by immune cells. Disease is modulated by interbacterial interactions as well as bacterial-host cell interactions resulting in microbial growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28bf4a8f652f812d4ec52683f14da2f0
https://doi.org/10.1101/2020.04.27.065144
https://doi.org/10.1101/2020.04.27.065144
Publikováno v:
Infection and Immunity
To successfully colonize host tissues, bacteria must respond to and detoxify many different host-derived antimicrobial compounds, such as nitric oxide (NO). NO has direct antimicrobial activity through attack on iron-sulfur (Fe-S) cluster-containing
Autor:
Nalat Siwapornchai, John M. Leong, Nang H. Tin Maung, Andrew Camilli, Rachel M. Gerstein, Elsa N. Bou Ghanem, Aaron E. Goodwin, Ernesto J. Muñoz-Elías, Stacie Clark
Publikováno v:
The Journal of Immunology. 200:3739-3751
Streptococcus pneumoniae commonly resides asymptomatically in the nasopharyngeal (NP) cavity of healthy individuals but can cause life-threatening pulmonary and systemic infections, particularly in the elderly. NP colonization results in a robust imm
To successfully colonize host tissues, bacteria must respond to and detoxify many different host-derived antimicrobial compounds, such as nitric oxide (NO). NO has direct antimicrobial activity through attack on iron-sulfur (Fe-S) cluster-containing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91e0f34786146983e4e742efbc48831c
Autor:
Elsa N, Bou Ghanem, Nang H Tin, Maung, Nalat, Siwapornchai, Aaron E, Goodwin, Stacie, Clark, Ernesto J, Muñoz-Elías, Andrew, Camilli, Rachel M, Gerstein, John M, Leong
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 201(11)
Streptococcus pneumoniae commonly resides asymptomatically in the nasopharyngeal (NP) cavity of healthy individuals but can cause life-threatening pulmonary and systemic infections, particularly in the elderly. NP colonization results in a robust imm