Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Stacie A, Dalrymple"'
Autor:
Jaehyeon Park, Harlan F Reese, Yun-Chou Tan, Hasim Zecic, Martin Stahl, Keshab Sarma, Renee Litman, Alejandra Trejo, William Bingenheimer, Michael Soth, David Michael Goldstein, Mary Welch, Eric Brian Sjogren, Man-Ling Sung, Sandra Frauchiger, Nolan James Dewdney, Bong San Pablo, Eva Papp, Daniel McWeeney, Ronald J. Hill, Paul Weller, Manjiri Ghate, JoAnn La Fargue, Brian Wong, Stacie A. Dalrymple, James Patrick Dunn, David Mark Rotstein, Richard T. Roberts, Bradford Graves, Rebecca T Suttman, Mcintosh Joel, Farrell Robert P, Andreas Kuglstatter, Chen Jian Jeffrey, Fujun Li, Humberto Bartolome Arzeno, Brad Loe, Tobias Gabriel
Publikováno v:
Journal of Medicinal Chemistry. 54:2255-2265
The development of a new series of p38α inhibitors resulted in the identification of two clinical candidates, one of which was advanced into a phase 2 clinical study for rheumatoid arthritis. The original lead, an lck inhibitor that also potently in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bdfa3e0a0a96eaca0eea2feab67e249
https://doi.org/10.1021/jm101423y
https://doi.org/10.1021/jm101423y
Autor:
Juthamas Sukbuntherng, Catherine Magill, John Eksterowicz, Doris Graupe, Michael J. Green, Penglie Zhang, Hyunjin M. Kim, Martin Sendzik, Peter Sabbatini, Jason Oeh, Jeffrey R. Spencer, Stacie A. Dalrymple, Peter R. Young, Katherine G. Moss, Andrew G. Myers, Neil H. Squires
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:4884-4888
Novel analogs of (-)-saframycin A are described. The analogs are shown to be potent inhibitors of the in vitro growth of several tumor cells in a broad panel and promising as leads for further optimization. The first in vivo studies in a solid tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::211f339c2f46146df07ee8a6fabe3a5f
https://doi.org/10.1016/j.bmcl.2006.06.085
https://doi.org/10.1016/j.bmcl.2006.06.085
Autor:
Peter R. Young, Jack R. Davis, Sriram Balasubramanian, Rafael A. Molina, Joseph J. Buggy, Stacie A. Dalrymple, Erik Verner, Ondine Callan, Liang Liu, Z. Alexander Cao, Christine Orr, Ling Leung, Brian E. Schultz, Kathryn E. Bass, YuQin Dai, Shawn Misialek, Martin Sendzik
Publikováno v:
Molecular Cancer Therapeutics. 5:1693-1701
CRA-026440 is a novel, broad-spectrum, hydroxamic acid–based inhibitor of histone deacetylase (HDAC) that shows antitumor and antiangiogenic activities in vitro and in vivo preclinically. CRA-026440 inhibited pure recombinant isozymes HDAC1, HDAC2,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4dfc96277b462e304646904a61ee240
https://doi.org/10.1158/1535-7163.mct-06-0042
https://doi.org/10.1158/1535-7163.mct-06-0042
Autor:
Maria E. Fuentes, Michael H Durnin, Stacie A. Dalrymple, David V. Goeddel, Kyoko Yamaguchi, Masato Tanaka, Kathy L Hardy
Publikováno v:
Immunity. 10(4):421-429
IkappaB kinase-alpha and -beta (IKK-alpha and IKK-beta), the catalytic subunits of the IKK complex, phosphorylate IkappaB proteins on specific serine residues, thus targeting IkappaB for degradation and activating the transcription factor NF-kappaB.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3bcaf16bf9b055682f0321934c132d
Autor:
Alexander J. Szalai, Frederik W. van Ginkel, Stacie A. Dalrymple, Richard Murray, Jerry R. McGhee, John E. Volanakis
Publikováno v:
The Journal of Immunology. 160:5294-5299
In vitro, IL-6 is the main inducer of the human C-reactive protein (CRP) gene, and IL-1 and steroids can enhance this effect. However, in mice, IL-6 is necessary but not sufficient for induction of the human CRP transgene, and testosterone is require
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b61e8b4a5cb6a6685963286840c2cce0
https://doi.org/10.4049/jimmunol.160.11.5294
https://doi.org/10.4049/jimmunol.160.11.5294
Publikováno v:
Immunological Reviews. 158:107-114
The Listeria monocytogenes (L. monocytogenes) infection model has been a useful system to evaluate the cellular interactions leading to host immunity. The initiation of the innate immune response in naive animals and subsequent progression to acquire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f8c5b3b27d1f4029cdba07e8d17062
https://doi.org/10.1111/j.1600-065x.1997.tb00996.x
https://doi.org/10.1111/j.1600-065x.1997.tb00996.x
Autor:
David M, Goldstein, Michael, Soth, Tobias, Gabriel, Nolan, Dewdney, Andreas, Kuglstatter, Humberto, Arzeno, Jeffrey, Chen, William, Bingenheimer, Stacie A, Dalrymple, James, Dunn, Robert, Farrell, Sandra, Frauchiger, JoAnn, La Fargue, Manjiri, Ghate, Bradford, Graves, Ronald J, Hill, Fujun, Li, Renee, Litman, Brad, Loe, Joel, McIntosh, Daniel, McWeeney, Eva, Papp, Jaehyeon, Park, Harlan F, Reese, Richard T, Roberts, David, Rotstein, Bong, San Pablo, Keshab, Sarma, Martin, Stahl, Man-Ling, Sung, Rebecca T, Suttman, Eric B, Sjogren, Yunchou, Tan, Alejandra, Trejo, Mary, Welch, Paul, Weller, Brian R, Wong, Hasim, Zecic
Publikováno v:
Journal of medicinal chemistry. 54(7)
The development of a new series of p38α inhibitors resulted in the identification of two clinical candidates, one of which was advanced into a phase 2 clinical study for rheumatoid arthritis. The original lead, an lck inhibitor that also potently in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cda31600d6054cc75ed83ea768d5f392
https://pubmed.ncbi.nlm.nih.gov/21375264
https://pubmed.ncbi.nlm.nih.gov/21375264
Publikováno v:
Blood. 81:2903-2915
We have used two in vitro models to identify genes whose expression may serve as markers of lineage commitment during the development of hematopoietic stem cells. One system involves the development in vitro of blastocyst-derived embryonic stem cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ba830af40941201d9c2a26dc838b01b
https://doi.org/10.1182/blood.v81.11.2903.bloodjournal81112903
https://doi.org/10.1182/blood.v81.11.2903.bloodjournal81112903
Autor:
Gill Adrian Liam, Csaba Lehel, Mcintosh Joel, Francisco Xavier Talamas, Roland J. Billedeau, Holger Wesche, David Clark, Eric Brian Sjogren, Matt Wright, Nigel Walker, Stacie A. Dalrymple, Sharada Shenvi Labadie, Camran Parast, Timothy D. Cushing, George Tonn, Michelle F. Browner, Keith A. M. Walker, Viola Bordunov, Pu-Ping Lu, Marie-Louise Smith, Chris Whitehead, Xiao He, Mario G. Cardozo, Juan C. Jaen, Chris Allen Broka, Peng Cheng, Youngsook Shin, Karen Berry, Vijay Baichwal, Shichang Miao, Ronald Charles Hawley, Xiaolin Hao, Michael DeGraffenreid, Marc Labelle
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(1)
A novel series of (E)-1-((2-(1-methyl-1H-imidazol-5-yl) quinolin-4-yl) methylene) thiosemicarbazides was discovered as potent inhibitors of IKKβ. In this Letter we document our early efforts at optimization of the quinoline core, the imidazole and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc82bc82b7e7cf09330f7c5b4a3deba2
https://pubmed.ncbi.nlm.nih.gov/21074993
https://pubmed.ncbi.nlm.nih.gov/21074993
Autor:
Karen Berry, Viola Bordunov, Shichang Miao, David Clark, George Tonn, Timothy D. Cushing, Ronald Charles Hawley, Gill Adrian Liam, Marc Labelle, Csaba Lehel, Pu-Ping Lu, Francisco Xavier Talamas, Vijay Baichwal, Roland J. Billedeau, Mario G. Cardozo, Mcintosh Joel, Peng Cheng, Marie-Louise Smith, Michael DeGraffenreid, Chris Whitehead, Stacie A. Dalrymple, Xiao He, Nigel Walker, Camran Parast, Xiaolin Hao, Holger Wesche, Matt Wright, Eric Brian Sjogren, Keith A. M. Walker, Juan C. Jaen, Chris Allen Broka, Sharada Shenvi Labadie, Michelle F. Browner, Youngsook Shin
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(1)
A novel series of (E)-1-((2-(1-methyl-1H-imidazol-5-yl) quinolin-4-yl) methylene) thiosemicarbazides was discovered as potent inhibitors of IKKβ. In this Letter we document our efforts at further optimization of this series, culminating in 2 with su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf43c755172d814362bce5fc139f29d9
https://pubmed.ncbi.nlm.nih.gov/21074992
https://pubmed.ncbi.nlm.nih.gov/21074992