Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Stacie, Canan"'
Autor:
Natalie Hawryluk, Li Zhiru, Clotilde Carlow, Suzanne Gokool, Simon Townson, Tamara Kreiss, Agnieszka Chojnowski, Monika Prorok, John Siekierka, Alexandra Ehrens, Marianne Koschel, Nathaly Lhermitte-Vallarino, Coralie Martin, Achim Hoerauf, Geraldine Hernandez, Stacie Canan, Vikram Khetani, Jerome Zeldis, Sabine Specht, Marc P. Hübner, Ivan Scandale
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 19, Iss , Pp 89-97 (2022)
Filarial diseases, including lymphatic filariasis and onchocerciasis, are considered among the most devastating of all tropical diseases, affecting over 86 million people worldwide. To control and more rapidly eliminate onchocerciasis requires treatm
Externí odkaz:
https://doaj.org/article/68b02e6e71f1432399da4c59040a7b3a
Autor:
Ruslana Bryk, Shashirekha Mundhra, Xiuju Jiang, Madeleine Wood, Daniel Pfau, Elaina Weber, Suna Park, Li Zhang, Colin Wilson, Renier Van der Westhuyzen, Leslie Street, Kelly Chibale, Matthew Zimmerman, Véronique Dartois, Nunzia Pastore, Andrea Ballabio, Natalie Hawryluk, Stacie Canan, Vikram Khetani, Joseph Camardo, Carl Nathan
Publikováno v:
PLoS Pathogens, Vol 16, Iss 6, p e1008567 (2020)
Efforts at host-directed therapy of tuberculosis have produced little control of the disease in experimental animals to date. This is not surprising, given that few specific host targets have been validated, and reciprocally, many of the compounds te
Externí odkaz:
https://doaj.org/article/36309ad8ba72424da920b60f55ea2dd4
Autor:
Nicola J. Curtin, Stephen E. Webber, Lan-Zhen Wang, Donald Skalitzky, David R. Newell, Karen A. Maegley, Suzanne Kyle, Zdenek Hostomsky, Stacie Canan, Michael A. Batey, Christopher R. Calabrese, Huw D. Thomas
Adobe PDF - MCT-06-0552--Suppl_Table_S1.pdf from Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f0b3fff940d1a4cd79259b67d4afb5
https://doi.org/10.1158/1535-7163.22485801
https://doi.org/10.1158/1535-7163.22485801
Autor:
Nicola J. Curtin, Stephen E. Webber, Lan-Zhen Wang, Donald Skalitzky, David R. Newell, Karen A. Maegley, Suzanne Kyle, Zdenek Hostomsky, Stacie Canan, Michael A. Batey, Christopher R. Calabrese, Huw D. Thomas
Poly(ADP-ribose) polymerase (PARP)-1 (EC 2.4.2.30) is a nuclear enzyme that promotes the base excision repair of DNA breaks. Inhibition of PARP-1 enhances the efficacy of DNA alkylating agents, topoisomerase I poisons, and ionizing radiation. Our aim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b1b5661cb9328ac5a8e732319794d9
https://doi.org/10.1158/1535-7163.c.6532086.v1
https://doi.org/10.1158/1535-7163.c.6532086.v1
Autor:
Taisuke, Tawaraishi, Atsuko, Ochida, Yuichiro, Akao, Sachiko, Itono, Masahiro, Kamaura, Thamina, Akther, Mitsuyuki, Shimada, Stacie, Canan, Sanjoy, Chowdhury, Yafeng, Cao, Kevin, Condroski, Ola, Engkvist, Amanda, Francisco, Sunil, Ghosh, Rina, Kaki, John M, Kelly, Chiaki, Kimura, Thierry, Kogej, Kazuya, Nagaoka, Akira, Naito, Garry, Pairaudeau, Constantin, Radu, Ieuan, Roberts, David, Shum, Nao-Aki, Watanabe, Huanxu, Xie, Shuji, Yonezawa, Osamu, Yoshida, Ryu, Yoshida, Charles, Mowbray, Benjamin, Perry
Publikováno v:
Journal of medicinal chemistry.
Probing multiple proprietary pharmaceutical libraries in parallel via virtual screening allowed rapid expansion of the structure-activity relationship (SAR) around hit compounds with moderate efficacy against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::098120064a818c49ef6eba16a4ffb203
https://pubmed.ncbi.nlm.nih.gov/36607408
https://pubmed.ncbi.nlm.nih.gov/36607408
Autor:
Stacie Canan, Takaya Togo, Linh Tram, Laura Denton, Xochina ElHilali-Pollard, Jun Gu, Jinglei Jiang, Chenglei Liu, Yan Zhao, Yanlong Zhao, Yingzhe Zheng, Yunping Zheng, Jingjing Yang, Michelle Arkin, Panpan Fan, Deqian Sun, Steven Wheeler, Adam Renslo
Heteroaromatic stacking interactions help stabilize protein tertiary structure and are important in drug binding, supramolecu-lar chemistry, and materials science. Although diverse computational and experimental approaches have been utilized to study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d887cc6adfdf75f3df7048a2aaac8ac
https://doi.org/10.26434/chemrxiv-2022-359ch
https://doi.org/10.26434/chemrxiv-2022-359ch
Publikováno v:
Methods in Molecular Biology ISBN: 9781493969920
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d757819a35b5221ae88210edda60719
https://doi.org/10.1007/978-1-4939-6993-7_18
https://doi.org/10.1007/978-1-4939-6993-7_18
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 780
This chapter describes the approaches taken in the development of the first PARP inhibitor to enter into clinical trial, AG-014699. We describe the general principles of crystal-based drug design, the purification, and crystallization of the PARP-1 c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c681ae83977dce76f901fdbbaad356a1
https://pubmed.ncbi.nlm.nih.gov/21870278
https://pubmed.ncbi.nlm.nih.gov/21870278
Publikováno v:
Journal of the American Chemical Society. 108:2762-2764
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e4816985e55b90e51fcaea9485af747
https://doi.org/10.1021/ja00270a050
https://doi.org/10.1021/ja00270a050