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Inducible expression of TGFβ, Snail and Zeb1 recapitulates EMT in vitro and in vivo in a NSCLC model
Autor:
Julie L.C. Kan, Stuart Thomson, David Epstein, Joseph S. Krueger, Maryland Rosenfeld-Franklin, Regina Sennello, John D. Haley, G. David Young, Peter Mercado, Jonathan A. Pachter, Krista Carey, Matthew O'Connor, Robert A. Wild, Stacia Silva, Gretchen M. Argast, Iain J. Mulford, Isabela Sujka-Kwok
Publikováno v:
Clinical & Experimental Metastasis. 28:593-614
The progression of cancer from non-metastatic to metastatic is the critical transition in the course of the disease. The epithelial to mesenchymal transition (EMT) is a mechanism by which tumor cells acquire characteristics that improve metastatic ef