Cochlear supporting cells require GAS2 for cytoskeletal architecture and hearing

Autor: Hannie Kremer, Kevin K. Ohlemiller, Staci M. Rakowiecki, Christian Gilissen, Jiddeke M. van de Kamp, Erdi Kucuk, Alex M Rohacek, Jeroen Smits, Jaap Oostrik, Amir Nankali, John S. Oghalai, Benjamin L. Prosser, Douglas J. Epstein, Klaus H. Kaestner, Tingfang Chen, Cornelis P. Lanting, Matthew A. Caporizzo, Ronald J.E. Pennings

Publikováno v: Developmental Cell, 56, 10, pp. 1526-1540.e7
Dev Cell
Developmental Cell, 56, 1526-1540.e7
Chen, T, Rohacek, A M, Caporizzo, M, Nankali, A, Smits, J J, Oostrik, J, Lanting, C P, Kücük, E, Gilissen, C, van de Kamp, J M, Pennings, R J E, Rakowiecki, S M, Kaestner, K H, Ohlemiller, K K, Oghalai, J S, Kremer, H, Prosser, B L & Epstein, D J 2021, ' Cochlear supporting cells require GAS2 for cytoskeletal architecture and hearing ', Developmental Cell, vol. 56, no. 10, pp. 1526-1540.e7 . https://doi.org/10.1016/j.devcel.2021.04.017
Developmental Cell, 56(10), 1526-1540.e7. Cell Press

In mammals, sound is detected by mechanosensory hair cells that are activated in response to vibrations at frequency-dependent positions along the cochlear duct. We demonstrate that inner ear supporting cells provide a structural framework for transm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dee4d64f9b711a9482e5c2b2919c854
https://repository.ubn.ru.nl/handle/2066/233882

The cochlear sensory epithelium derives from Wnt responsive cells in the dorsomedial otic cup

Autor: Staci M. Rakowiecki, Alexander S. Brown, Douglas J. Epstein, James Y. H. Li

Publikováno v: Developmental Biology. 399:177-187

Wnt1 and Wnt3a secreted from the dorsal neural tube were previously shown to regulate a gene expression program in the dorsal otic vesicle that is necessary for vestibular morphogenesis (Riccomagno et al., 2005. Genes Dev. 19, 1612-1623). Unexpectedl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc535acc3bc0456363affa2adb95f06
https://doi.org/10.1016/j.ydbio.2015.01.001

Loss of Notch Activity in the Developing Central Nervous System Leads to Increased Cell Death

Autor: Heather A. Mason, Thomas Gridley, Staci M. Rakowiecki, Gord Fishell

Publikováno v: Developmental Neuroscience. 28:49-57

Many cells in the mammalian brain undergo apoptosis as a normal and critical part of development but the signals that regulate the survival and death of neural progenitor cells and the neurons they produce are not well understood. The Notch signaling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24dcf46cb0a6a8e1f9dad6b7696c7b95
https://doi.org/10.1159/000090752

Notch signaling coordinates the patterning of striatal compartments

Autor: Susana Vaz Nery, Staci M. Rakowiecki, Yuanyuan Huang, Myrto Raftopoulou, Gord Fishell, Thomas Gridley, Heather A. Mason

Publikováno v: Development (Cambridge, England). 132(19)

Numerous lines of evidence suggest that Notch signaling plays a pivotal role in controlling the production of neurons from progenitor cells. However,most experiments have relied on gain-of-function approaches because perturbation of Notch signaling r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::456dc94298d7d05211159db34cdfb477
https://pubmed.ncbi.nlm.nih.gov/16120638

Loss of Notch Activity in the Developing Central Nervous System Leads to Increased Cell Death.

Autor: Mason, Heather A., Rakowiecki, Staci M., Gridley, Thomas, Fishell, Gord

Publikováno v: Developmental Neuroscience; 2006, Vol. 28 Issue 1/2, p49-57, 9p, 5 Diagrams