Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Staci L. Solin"'
Autor:
Laura E. Schultz, Jeffrey A. Haltom, Maira P. Almeida, Wesley A. Wierson, Staci L. Solin, Trevor J. Weiss, Jordan A. Helmer, Elizabeth J. Sandquist, Heather R. Shive, Maura McGrail
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 6 (2018)
In this study, we used comparative genomics and developmental genetics to identify epigenetic regulators driving oncogenesis in a zebrafish retinoblastoma 1 (rb1) somatic-targeting model of RB1 mutant embryonal brain tumors. Zebrafish rb1 brain tumor
Externí odkaz:
https://doaj.org/article/d7541aa813124c06aaa550fd7eeed8b0
Autor:
Dennis A. Webster, Alla Bondareva, Nathalia de Lima E Martins Lara, Lin Su, Taylor Goldsmith, Staci L. Solin, Ina Dobrinski, Daniel F. Carlson
Publikováno v:
Frontiers in Genetics, Vol 11 (2021)
Frontiers in Genetics
Frontiers in Genetics
To study the pathophysiology of human diseases, develop innovative treatments, and refine approaches for regenerative medicine require appropriate preclinical models. Pigs share physiologic and anatomic characteristics with humans and are genetically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2694a4c4755b0a11637d03f44c0e1a3
Autor:
Laura E. Schultz, Judith Syrkin-Nikolau, Janna M. Lovan, Maura McGrail, Andrew J. Severin, Deborah E. Lincow, Donald S. Sakaguchi, Staci L. Solin, Welsey A. Wierson
Publikováno v:
Zebrafish
In the central nervous system injury induces cellular reprogramming and progenitor proliferation, but the molecular mechanisms that limit regeneration and prevent tumorigenesis are not completely understood. We previously described a zebrafish optic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7eb23bfbb28f259fa60441cb86cf637
https://doi.org/10.1089/zeb.2016.1366
https://doi.org/10.1089/zeb.2016.1366
Autor:
Wesley A. Wierson, Jordan M. Welker, Maira P. Almeida, Carla M. Mann, Dennis A. Webster, Melanie E. Torrie, Trevor J. Weiss, Macy K. Vollbrecht, Merrina Lan, Kenna C. McKeighan, Jacklyn Levey, Zhitao Ming, Alec Wehmeier, Christopher S. Mikelson, Jeffrey A. Haltom, Kristen M. Kwan, Chi-Bin Chien, Darius Balciunas, Stephen C. Ekker, Karl J. Clark, Beau R. Webber, Branden Moriarity, Staci L. Solin, Daniel F. Carlson, Drena L. Dobbs, Maura McGrail, Jeffrey J. Essner
Choices for genome engineering and integration involve high efficiency with little or no target specificity or high specificity with low activity. Here, we describe a targeted integration strategy, called GeneWeld, and a vector series for gene taggin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd33a5971a72194470bd7f917dad8410
Autor:
Jeffrey A. Haltom, Laura E. Schultz, Maura McGrail, Jordan A. Helmer, Elizabeth J. Sandquist, Trevor J. Weiss, Staci L. Solin, Maira P. Almeida, Heather R. Shive, Wesley A. Wierson
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 6 (2018)
Disease Models & Mechanisms
Disease Models & Mechanisms
In this study, we used comparative genomics and developmental genetics to identify epigenetic regulators driving oncogenesis in a zebrafish retinoblastoma 1 (rb1) somatic-targeting model of RB1 mutant embryonal brain tumors. Zebrafish rb1 brain tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c034213194652264f2226f6ca559181
http://dmm.biologists.org/content/11/6/dmm034124
http://dmm.biologists.org/content/11/6/dmm034124
Publikováno v:
Scientific Reports
Scientific reports, vol 5, iss 1
Scientific reports, vol 5, iss 1
Investigating the in vivo role of tumor suppressor genes in cancer is technically challenging due to their essential requirement during early animal development. To address this bottleneck, we generated genetic mosaic adult zebrafish using TALEN geno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1454bfea617c281620dad29acc20ae95
http://europepmc.org/articles/PMC4642565
http://europepmc.org/articles/PMC4642565
Autor:
Judith Syrkin-Nikolau, Crystal A. Jones, Hui-Hsien Chou, Jeffrey J. Essner, Joshua Mauldin, Jesse M. Hostetter, Laura E. Schultz, J. Douglas Cameron, Andrew J. Severin, Pavel A. Brodskiy, Jasmine M. Linn, Elizabeth M. Whitley, Staci L. Solin, Ying Wang, Donald S. Sakaguchi, Maura McGrail, Deborah E. Lincow
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 12, p e114888 (2014)
PLoS ONE, Vol 9, Iss 12, p e114888 (2014)
In this study we describe the molecular and cellular characterization of a zebrafish mutant that develops tumors in the optic pathway. Heterozygous Tg(flk1:RFP)is18 transgenic adults develop tumors of the retina, optic nerve and optic tract. Molecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b78b336a29f33884264311431475710
http://europepmc.org/articles/PMC4259487
http://europepmc.org/articles/PMC4259487
Autor:
Stephen C. Ekker, Maura McGrail, Melissa S. McNulty, Jordan M. Welker, Karl J. Clark, Wesley A. Wierson, Staci L. Solin, Jeffery J. Essner, Ying Wang, Ellen E. Tisdale, Tanya L. Poshusta
Publikováno v:
Human Gene Therapy. 27:423-424
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::954088d18c8622588a242805dd926f93
https://doi.org/10.1089/hum.2016.012
https://doi.org/10.1089/hum.2016.012
Autor:
Maura McGrail, Heather R. Shive, Jeffrey A. Haltom, Staci L. Solin, Jeffrey J. Essner, Laura E. Schultz
Publikováno v:
Cancer Research. 76:4179-4179
We examined the gene expression signature of zebrafish brain tumors induced by somatic inactivation of the retinoblastoma tumor suppressor rb1 to determine the similarity with human CNS primitive neuroectodermal tumors (PNETs). Childhood CNS PNETs ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::810d213e6fca2860bd3958dd0d64bf69
https://doi.org/10.1158/1538-7445.am2016-4179
https://doi.org/10.1158/1538-7445.am2016-4179
Publikováno v:
Cancer Research. 75:A24-A24
Purpose: We found that targeted somatic inactivation of rb1 leads to solid tumor formation in the central nervous system of adult zebrafish. The purpose of our study was to characterize the histological and genetic features of the tumors. Methods: Ze
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a993cad3cb685b1657c5a0e910f3795
https://doi.org/10.1158/1538-7445.brain15-a24
https://doi.org/10.1158/1538-7445.brain15-a24