Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Staci A Weaver"'
Autor:
Xin Tong, Zunaira Chaudhry, Chih-Chun Lee, Robert N. Bone, Sukrati Kanojia, Judith Maddatu, Paul Sohn, Staci A. Weaver, Morgan A. Robertson, Irina Petrache, Carmella Evans-Molina, Tatsuyoshi Kono
Publikováno v:
Molecular Metabolism, Vol 37, Iss , Pp 100975- (2020)
Objectives: Epidemiological studies indicate that first- and second-hand cigarette smoke (CS) exposure are important risk factors for the development of type 2 diabetes (T2D). Additionally, elevated diabetes risk has been reported to occur within a s
Externí odkaz:
https://doaj.org/article/0fe5d12c31684de0b963d0b776686fe2
Publikováno v:
Journal of Clinical and Translational Science, Vol 5, Pp 16-17 (2021)
ABSTRACT IMPACT: The proposed study has the potential to inform new paradigms of type 1 diabetes prevention and therapy with the overall goal of improving β cell health during autoimmunity. OBJECTIVES/GOALS: Type 1 diabetes (T1D) results from immune
Externí odkaz:
https://doaj.org/article/5d308331388c4a0887c1f740f15cdd19
Autor:
Rebecca K Davidson, Staci A Weaver, Nolan Casey, Sukrati Kanojia, Elise Hogarth, Rebecca Schneider Aguirre, Emily K Sims, Carmella Evans-Molina, Jason M Spaeth
Publikováno v:
J Mol Endocrinol
Type 2 diabetes (T2D) is associated with loss of transcription factors (TFs) from a subset of failing β-cells. Among these TFs is Pdx1, which controls the expression of numerous genes involved in maintaining β-cell function and identity. Pdx1 activ
Autor:
Hitoshi Iida, Tatsuyoshi Kono, Chih-Chun Lee, Preethi Krishnan, Matthew C. Arvin, Staci A. Weaver, Timothy S. Jarvela, Robert N. Bone, Xin Tong, Peter Arvan, Iris Lindberg, Carmella Evans-Molina
Increased circulating levels of incompletely processed insulin (i.e. proinsulin) are observed clinically in both type 1 and type 2 diabetes; however, the mechanisms underlying impaired proinsulin processing remain incompletely understood. Here, we id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4650c5d2e43900ce537422c5527ef5b1
https://doi.org/10.1101/2022.06.13.495980
https://doi.org/10.1101/2022.06.13.495980
Autor:
Charanya Muralidharan, Tatsuyoshi Kono, Xin Tong, Staci A. Weaver, Robert N. Bone, Preethi Krishnan, Carmella Evans-Molina
The β cell Golgi apparatus serves as a significant store of intracellular Ca2+ and an important site of proinsulin maturation. However, the contribution of Golgi Ca2+ to diabetes pathophysiology is unknown. The Golgi primarily utilizes the Secretory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd978efd22c8ed8f5f94d1e7de5b7a6e
https://doi.org/10.1101/2021.08.30.458203
https://doi.org/10.1101/2021.08.30.458203
Publikováno v:
Diabetes. 70
Store-operated calcium entry (SOCE) functions to refill endoplasmic reticulum (ER) Ca2+ stores in response to ER Ca2+ depletion through gating of plasmalemmal Orai channels by the ER Ca2+ sensor STIM1. Dysfunctional β cell SOCE has been observed in
Publikováno v:
Diabetes. 70
Type 1 diabetes (T1D) results from immune-mediated destruction of pancreatic β cells. Recent data suggest that activation of senescence and acquisition of a senescence-associated secretory phenotype (SASP) by β cells may contribute to T1D pathogene
Publikováno v:
Diabetes. 70
MicroRNAs (miRNAs) are small non-coding RNAs that function as modulators of gene expression. We previously identified upregulation of miR-146a-5p in pancreatic islets treated with proinflammatory cytokines and in human pancreatic sections from indivi
Publikováno v:
Diabetes. 69
Store-operated calcium entry (SOCE) is a mechanism that functions to refill endoplasmic reticulum (ER) Ca2+ stores in response to ER Ca2+ depletion, through gating of plasmallemal Ora channels by the ER Ca2+ sensor STIM1. Dysfunctional β cell SOCE h
Autor:
Lyudmila Sidorenko, Woosley Aaron T, Tzuu-fen Lee, Glancy Todd P, P. Ann Owens Merlo, William Moskal, Scott Bevan, Po-Hao Wang, Xiujuan Wang, Terence A. Walsh, Blake C. Meyers, Xiaozeng Yang, Staci A. Weaver, Shreedharan Sriram
Publikováno v:
Nature plants. 3(11)
The molecular basis of transgene susceptibility to silencing is poorly characterized in plants; thus, we evaluated several transgene design parameters as means to reduce heritable transgene silencing. Analyses of Arabidopsis plants with transgenes en