Directing group-controlled regioselectivity in an enzymatic C-H bond oxygenation

Autor: Negretti, Solymar, Narayan, Alison RH, Chiou, Karoline C, Kells, Petrea M, Stachowski, Jessica L, Hansen, Douglas A, Podust, Larissa M, Montgomery, John, Sherman, David H

Publikováno v: Journal of the American Chemical Society, vol 136, iss 13

Highly regioselective remote hydroxylation of a natural product scaffold is demonstrated by exploiting the anchoring mechanism of the biosynthetic P450 monooxygenase PikCD50N-RhFRED. Previous studies have revealed structural and biochemical evidence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::93350dc64de6a347eaf89b042cdb2414
https://escholarship.org/uc/item/30q011w7

Directing group-controlled regioselectivity in an enzymatic C-H bond oxygenation.

Autor: Negretti S; Department of Medicinal Chemistry, §Life Sciences Institute, ⊥Department of Chemistry, and ∥Department of Microbiology & Immunology, University of Michigan , Ann Arbor, Michigan 48109, United States., Narayan AR, Chiou KC, Kells PM, Stachowski JL, Hansen DA, Podust LM, Montgomery J, Sherman DH

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2014 Apr 02; Vol. 136 (13), pp. 4901-4. Date of Electronic Publication: 2014 Mar 21.