Selective inhibition of human translation termination by a drug-like compound

Autor: Wenfei Li, Stacey Tsai-Lan Chang, Fred. R. Ward, Jamie H. D. Cate

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)

The drug-like compound PF846 and its derivatives inhibit the translation of specific mRNAs by the human ribosome. Here the authors show how PF846 arrests translation at the stop codon by slowing hydrolysis of the protein nascent chain at the ribosome

Externí odkaz: https://doaj.org/article/b86e399a4ec045d89db7d9e3ea9c2b22

A highly efficient human cell-free translation system

Autor: Nikolay A. Aleksashin, Stacey Tsai-Lan Chang, Jamie H. D. Cate

Publikováno v: bioRxiv

Cell-free protein synthesis (CFPS) systems enable easyin vitroexpression of proteins with many scientific, industrial, and therapeutic applications. Here we present an optimized, highly efficient human cell-free translation system that bypasses many

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d39b3d0a2bc74b4f35a340d5ed53c6f4
https://doi.org/10.1101/2023.02.09.527910

Smoothing the Way Into School Nursing Practice

Autor: Stacey Tsai, Rachel McClanahan

Publikováno v: NASN school nurse (Print). 37(4)

Role transition can be a struggle for new or seasoned nurses moving into the specialty of school. School nursing, a specialized field that entails a scope of practice and competencies very different from other settings, is not taught in many primary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18cd52271ff50191400015a93e276e70
https://pubmed.ncbi.nlm.nih.gov/35168440

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A highly efficient human cell-free translation system.

Autor: Aleksashin NA; Innovative Genomics Institute, University of California-Berkeley, Berkeley, CA, USA.; Department of Molecular & Cell Biology, University of California-Berkeley, Berkeley, CA, USA., Chang ST; Innovative Genomics Institute, University of California-Berkeley, Berkeley, CA, USA.; Department of Molecular & Cell Biology, University of California-Berkeley, Berkeley, CA, USA., Cate JHD; Innovative Genomics Institute, University of California-Berkeley, Berkeley, CA, USA.; Department of Molecular & Cell Biology, University of California-Berkeley, Berkeley, CA, USA.; Department of Chemistry, University of California-Berkeley, Berkeley, CA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 May 23. Date of Electronic Publication: 2023 May 23.