Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Stacey Stauffer"'
Autor:
Kajal Biswas, Alexander Y. Mitrophanov, Sounak Sahu, Teresa Sullivan, Eileen Southon, Darryl Nousome, Susan Reid, Sakshi Narula, Julia Smolen, Trisha Sengupta, Maximilian Riedel-Topper, Medha Kapoor, Anav Babbar, Stacey Stauffer, Linda Cleveland, Mayank Tandon, Tyler Malys, Shyam K. Sharan
Publikováno v:
Cell Reports: Methods, Vol 3, Iss 11, Pp 100628- (2023)
Summary: Sequencing of genes, such as BRCA1 and BRCA2, is recommended for individuals with a personal or family history of early onset and/or bilateral breast and/or ovarian cancer or a history of male breast cancer. Such sequencing efforts have resu
Externí odkaz:
https://doaj.org/article/987643d067d648409a1023e1fa88a4ed
Autor:
Kajal Biswas, Martin Couillard, Luca Cavallone, Sandra Burkett, Stacey Stauffer, Betty K. Martin, Eileen Southon, Susan Reid, Teri M. Plona, Ryan N. Baugher, Stephanie D. Mellott, Kristen M. Pike, Mary E. Albaugh, Chelsea Maedler-Kron, Nancy Hamel, Lino Tessarollo, Victoria Marcus, William D. Foulkes, Shyam K. Sharan
Publikováno v:
Cell Death and Disease, Vol 12, Iss 9, Pp 1-11 (2021)
Abstract Hereditary non-polyposis colorectal cancer, now known as Lynch syndrome (LS) is one of the most common cancer predisposition syndromes and is caused by germline pathogenic variants (GPVs) in DNA mismatch repair (MMR) genes. A common founder
Externí odkaz:
https://doaj.org/article/60a05c57c3c54a0ab1c477a7c5faeeec
Autor:
Pankaj Pathak, Yotam Blech-Hermoni, Kalpana Subedi, Jessica Mpamugo, Charissa Obeng-Nyarko, Rachel Ohman, Ilda Molloy, Malcolm Kates, Jessica Hale, Stacey Stauffer, Shyam K. Sharan, Ami Mankodi
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Pathak et al. identify LDB3, a striated muscle PDZ-LIM protein, as a signaling adaptor in a major mechanosensor assembly through interactions with filamin C, HSPA8, and PKCα. When LDB3 is mutated, PKCα and TSC2-mTOR mediated homeostasis is impaired
Externí odkaz:
https://doaj.org/article/d4e302a88eb748a8be9622e9386d26e5
Autor:
Kajal Biswas, Gary B. Lipton, Stacey Stauffer, Teresa Sullivan, Linda Cleveland, Eileen Southon, Susan Reid, Valentin Magidson, Edwin S. Iversen, Shyam K. Sharan
Publikováno v:
npj Genomic Medicine, Vol 5, Iss 1, Pp 1-16 (2020)
Abstract Sequencing-based genetic tests to identify individuals at increased risk of hereditary breast and ovarian cancers have resulted in the identification of more than 40,000 sequence variants of BRCA1 and BRCA2. A majority of these variants are
Externí odkaz:
https://doaj.org/article/040ac1e333f54a36a947eae448e108dd
Autor:
Nirmala Sirisena, Kajal Biswas, Teresa Sullivan, Stacey Stauffer, Linda Cleveland, Eileen Southon, Vajira H. W. Dissanayake, Shyam K. Sharan
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-5 (2020)
Abstract Next-generation sequencing of Sri Lankan families with inherited cancer syndromes resulted in the identification of five BRCA2 variants of unknown clinical significance. Interpreting such variants poses significant challenges for both clinic
Externí odkaz:
https://doaj.org/article/cc565824eef444bba709fc44ba390f05
Autor:
Xia Ding, Arnab Ray Chaudhuri, Elsa Callen, Yan Pang, Kajal Biswas, Kimberly D. Klarmann, Betty K. Martin, Sandra Burkett, Linda Cleveland, Stacey Stauffer, Teresa Sullivan, Aashish Dewan, Hanna Marks, Anthony T. Tubbs, Nancy Wong, Eugen Buehler, Keiko Akagi, Scott E. Martin, Jonathan R. Keller, André Nussenzweig, Shyam K. Sharan
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The PARP inhibitor olaparib is an approved treatment method for women with BRCA1 and BRCA2 mutation associated cancers. Here the authors show that olaparib can contribute to synthetic viability of cells if PARP1 is inhibited before BRCA2 loss.
Externí odkaz:
https://doaj.org/article/cf505f822a744ac9ab12008610c61b55
Autor:
Katie E. Hebron, Xiaolin Wan, Jacob S. Roth, David J. Liewehr, Nancy E. Sealover, William J.E. Frye, Angela Kim, Stacey Stauffer, Olivia L. Perkins, Wenyue Sun, Kristine A. Isanogle, Christina M. Robinson, Amy James, Parirokh Awasthi, Priya Shankarappa, Xiaoling Luo, Haiyan Lei, Donna Butcher, Roberta Smith, Elijah F. Edmondson, Jin-Qiu Chen, Noemi Kedei, Cody J. Peer, Jack F. Shern, W. Douglas Figg, Lu Chen, Matthew D. Hall, Simone Difilippantonio, Frederic G. Barr, Robert L. Kortum, Robert W. Robey, Angelina V. Vaseva, Javed Khan, Marielle E. Yohe
Publikováno v:
Clinical Cancer Research. 29:472-487
Purpose: PAX-fusion negative rhabdomyosarcoma (FN RMS) is driven by alterations in the RAS/MAP kinase pathway and is partially responsive to MEK inhibition. Overexpression of IGF1R and its ligands is also observed in FN RMS. Preclinical and clinical
Autor:
Marielle E. Yohe, Javed Khan, Angelina V. Vaseva, Robert W. Robey, Robert L. Kortum, Frederic G. Barr, Simone Difilippantonio, Matthew D. Hall, Lu Chen, W. Douglas Figg, Jack F. Shern, Cody J. Peer, Noemi Kedei, Jin-Qiu Chen, Elijah F. Edmondson, Roberta Smith, Donna Butcher, Haiyan Lei, Xiaoling Luo, Priya Shankarappa, Parirokh Awasthi, Amy James, Christina M. Robinson, Kristine A. Isanogle, Wenyue Sun, Olivia L. Perkins, Stacey Stauffer, Angela Kim, William J.E. Frye, Nancy E. Sealover, David J. Liewehr, Jacob S. Roth, Xiaolin Wan, Katie E. Hebron
Pharmacodynamic response to trametinib/ganitumab in xenograft models does not predict tumor shrinkage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d7c566bea37a5d8427b5ace824dcd1e
https://doi.org/10.1158/1078-0432.22488359
https://doi.org/10.1158/1078-0432.22488359
Autor:
Marielle E. Yohe, Javed Khan, Angelina V. Vaseva, Robert W. Robey, Robert L. Kortum, Frederic G. Barr, Simone Difilippantonio, Matthew D. Hall, Lu Chen, W. Douglas Figg, Jack F. Shern, Cody J. Peer, Noemi Kedei, Jin-Qiu Chen, Elijah F. Edmondson, Roberta Smith, Donna Butcher, Haiyan Lei, Xiaoling Luo, Priya Shankarappa, Parirokh Awasthi, Amy James, Christina M. Robinson, Kristine A. Isanogle, Wenyue Sun, Olivia L. Perkins, Stacey Stauffer, Angela Kim, William J.E. Frye, Nancy E. Sealover, David J. Liewehr, Jacob S. Roth, Xiaolin Wan, Katie E. Hebron
Related to Figure 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd7fae2aafc437f40291da739fe21d2
https://doi.org/10.1158/1078-0432.22488377.v1
https://doi.org/10.1158/1078-0432.22488377.v1
Autor:
Marielle E. Yohe, Javed Khan, Angelina V. Vaseva, Robert W. Robey, Robert L. Kortum, Frederic G. Barr, Simone Difilippantonio, Matthew D. Hall, Lu Chen, W. Douglas Figg, Jack F. Shern, Cody J. Peer, Noemi Kedei, Jin-Qiu Chen, Elijah F. Edmondson, Roberta Smith, Donna Butcher, Haiyan Lei, Xiaoling Luo, Priya Shankarappa, Parirokh Awasthi, Amy James, Christina M. Robinson, Kristine A. Isanogle, Wenyue Sun, Olivia L. Perkins, Stacey Stauffer, Angela Kim, William J.E. Frye, Nancy E. Sealover, David J. Liewehr, Jacob S. Roth, Xiaolin Wan, Katie E. Hebron
Purpose:PAX-fusion negative rhabdomyosarcoma (FN RMS) is driven by alterations in the RAS/MAP kinase pathway and is partially responsive to MEK inhibition. Overexpression of IGF1R and its ligands is also observed in FN RMS. Preclinical and clinical s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f2495e02f2004856ed709224efafc9
https://doi.org/10.1158/1078-0432.c.6532697.v1
https://doi.org/10.1158/1078-0432.c.6532697.v1