Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Stacey N Keenan"'
Autor:
Hamzeh Karimkhanloo, Stacey N. Keenan, Jacqueline Bayliss, William De Nardo, Paula M. Miotto, Camille J. Devereux, Shuai Nie, Nicholas A. Williamson, Andrew Ryan, Matthew J. Watt, Magdalene K. Montgomery
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Non-alcoholic steatohepatitis (NASH), characterized as the joint presence of steatosis, hepatocellular ballooning and lobular inflammation, and liver fibrosis are strong contributors to liver-related and overall mortality. Despite the high g
Externí odkaz:
https://doaj.org/article/0f81f952cf38469ca8daa7ce5886971f
Autor:
Anne Senabouth, Maciej Daniszewski, Grace E. Lidgerwood, Helena H. Liang, Damián Hernández, Mehdi Mirzaei, Stacey N. Keenan, Ran Zhang, Xikun Han, Drew Neavin, Louise Rooney, Maria Isabel G. Lopez Sanchez, Lerna Gulluyan, Joao A. Paulo, Linda Clarke, Lisa S. Kearns, Vikkitharan Gnanasambandapillai, Chia-Ling Chan, Uyen Nguyen, Angela M. Steinmann, Rachael A. McCloy, Nona Farbehi, Vivek K. Gupta, David A. Mackey, Guy Bylsma, Nitin Verma, Stuart MacGregor, Matthew J. Watt, Robyn H. Guymer, Joseph E. Powell, Alex W. Hewitt, Alice Pébay
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Age-related macular degeneration (AMD) is a leading cause of vision loss, and there is no approved treatment for AMD with geographic atrophy. Here, the authors used transcriptomic and proteomic analyses of patient induced pluripotent stem cell-derive
Externí odkaz:
https://doaj.org/article/26ee70153c844e808b5ef6d67e2ac7a9
Autor:
Magdalene K. Montgomery, Jacqueline Bayliss, Shuai Nie, William De Nardo, Stacey N. Keenan, Paula M. Miotto, Hamzeh Karimkhanloo, Cheng Huang, Ralf B. Schittenhelm, Anthony S. Don, Andrew Ryan, Nicholas A. Williamson, Geraldine J. Ooi, Wendy A. Brown, Paul R. Burton, Benjamin L. Parker, Matthew J. Watt
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Non-alcoholic steatohepatitis (NASH) and type 2 diabetes are closely linked, but the connecting pathophysiological mechanisms are incompletely understood. Here the authors identify arylsulfatase A as a NASH-induced hepatokine that inhibits hepatic ly
Externí odkaz:
https://doaj.org/article/0e3d36630f204b8aa3e526d0e0913eb1
Autor:
William De Nardo, Paula M. Miotto, Jacqueline Bayliss, Shuai Nie, Stacey N. Keenan, Magdalene K. Montgomery, Matthew J. Watt
Publikováno v:
Molecular Metabolism, Vol 60, Iss , Pp 101491- (2022)
Objective: Non-alcoholic fatty liver disease (NAFLD) is linked to impaired lipid metabolism and systemic insulin resistance, which is partly mediated by altered secretion of liver proteins known as hepatokines. Regular physical activity can resolve N
Externí odkaz:
https://doaj.org/article/703f3df833344ba2a9037ed17054464f
Autor:
Vanessa R. Haynes, Stacey N. Keenan, Jackie Bayliss, Erin M. Lloyd, Peter J. Meikle, Miranda D. Grounds, Matthew J. Watt
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 8, Pp 1350-1364 (2019)
Defects in the gene coding for dysferlin, a membrane-associated protein, affect many tissues, including skeletal muscles, with a resultant myopathy called dysferlinopathy. Dysferlinopathy manifests postgrowth with a progressive loss of skeletal muscl
Externí odkaz:
https://doaj.org/article/7d9fe4b4ed4445e6bce7caceba7f7bda
Autor:
Stacey N. Keenan, William De Nardo, Jieqiong Lou, Ralf B. Schittenhelm, Magdalene K. Montgomery, James G. Granneman, Elizabeth Hinde, Matthew J. Watt
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100016- (2021)
Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). We sought to identify
Externí odkaz:
https://doaj.org/article/fa5a9be0f3824de49839e18d04e01713
Autor:
Camille J. Devereux, Jacqueline Bayliss, Stacey N. Keenan, Magdalene K. Montgomery, Matthew J. Watt
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 324:E187-E198
Dysregulation of hepatic lipid metabolism is a hallmark of nonalcoholic fatty liver disease. Here, we show that dual inhibition of the de novo lipogenesis enzyme, ACC, and hepatic deletion of the fatty acid transporter, CD36, was ineffective for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::987c0a9ff0901501938860c7cb047bd1
https://doi.org/10.1152/ajpendo.00161.2022
https://doi.org/10.1152/ajpendo.00161.2022
Autor:
Magdalene K. Montgomery, Jacqueline Bayliss, Shuai Nie, William de Nardo, Stacey N. Keenan, Marziyeh Anari, Amanuiel Z. Taddese, Nicholas A. Williamson, Geraldine J. Ooi, Wendy A. Brown, Paul R. Burton, Paul Gregorevic, Craig A. Goodman, Kevin I. Watt, Matthew J. Watt
Publikováno v:
Diabetes. 72:715-727
Non-alcoholic fatty liver disease (NAFLD) and impaired glycaemic control are closely linked, however, the pathophysiological mechanisms underpinning this bidirectional relationship remain unresolved. The high secretory capacity of the liver and impai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19fb2002fab7eac62bf27db230f50f5d
https://doi.org/10.2337/db22-0590
https://doi.org/10.2337/db22-0590
Autor:
Magdalene K. Montgomery, Stacey N Keenan, David A Wattchow, Damien J. Keating, Emily W. Sun, Matthew J. Watt, Hamzeh Karimkhanloo
Publikováno v:
Journal of Endocrinology. 248:167-179
Cathepsin S (CTSS) is a cysteine protease that regulates many physiological processes and is increased in obesity and type 2 diabetes. While previous studies show that deletion of CTSS improves glycaemic control through suppression of hepatic glucose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7245e3dfe894bf0386b064e62b2e21b8
https://doi.org/10.1530/joe-20-0408
https://doi.org/10.1530/joe-20-0408
Autor:
Matthew J. Watt, Jennifer Chi Yi Lo, Ruth C. R. Meex, Magdalene K. Montgomery, Stacey N Keenan, Andrew Ryan, Shuai Nie
Publikováno v:
Diabetes, 68(3), 543-555. American Diabetes Association
Defects in hepatic lipid metabolism cause nonalcoholic fatty liver disease and insulin resistance, and these pathologies are closely linked. Regulation of lipid droplet metabolism is central to the control of intracellular fatty acid fluxes, and peri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3283a8ebe207a69d725d652cea05d9ca
https://doi.org/10.2337/db18-0670
https://doi.org/10.2337/db18-0670