Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Stacey Melquist"'
Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases
Autor:
Manikandan Narayanan, Jimmy L Huynh, Kai Wang, Xia Yang, Seungyeul Yoo, Joshua McElwee, Bin Zhang, Chunsheng Zhang, John R Lamb, Tao Xie, Christine Suver, Cliona Molony, Stacey Melquist, Andrew D Johnson, Guoping Fan, David J Stone, Eric E Schadt, Patrizia Casaccia, Valur Emilsson, Jun Zhu
Publikováno v:
Molecular Systems Biology, Vol 10, Iss 7, Pp 1-16 (2014)
Abstract Using expression profiles from postmortem prefrontal cortex samples of 624 dementia patients and non‐demented controls, we investigated global disruptions in the co‐regulation of genes in two neurodegenerative diseases, late‐onset Alzh
Externí odkaz:
https://doaj.org/article/ad673633ea9c41b9b14d2c564cc9243f
Autor:
Michael J. Koren, Patrick Maurice Moriarty, Seth J. Baum, Joel Neutel, Martha Hernandez-Illas, Howard S. Weintraub, Monica Florio, Helina Kassahun, Stacey Melquist, Tracy Varrieur, Saptarsi M. Haldar, Winnie Sohn, Huei Wang, Mary Elliott-Davey, Brooke M. Rock, Tao Pei, Oliver Homann, Jennifer Hellawell, Gerald F. Watts
Publikováno v:
Nature Medicine. 28:96-103
Compelling evidence supports a causal role for lipoprotein(a) (Lp(a)) in cardiovascular disease. No pharmacotherapies directly targeting Lp(a) are currently available for clinical use. Here we report the discovery and development of olpasiran, a firs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::678f185b03c180f42d8ec3d9c920d969
https://doi.org/10.1038/s41591-021-01634-w
https://doi.org/10.1038/s41591-021-01634-w
Autor:
Gerald Watts, Christian Schwabe, Russell Scott, Patrick Gladding, David Sullivan, John Baker, Peter Clifton, Bruce Given, James Hamilton, Stacey Melquist, Ting Chang, Rong Zhou, Javier San Martin, Daniel Gaudet, Ira Goldberg, Joshua Knowles, Robert Hegele, Christie Ballantyne
Elevated triglycerides and non-HDL-cholesterol (C) are risk factors for atherosclerotic cardiovascular disease (ASCVD). AROANG3 is a RNA interference therapy targeting hepatocyte production of angiopoietin-like protein 3 (ANGPTL3), a regulator of lip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c807d27ab8f272dec307922d36a3ad35
https://doi.org/10.21203/rs.3.rs-2097342/v1
https://doi.org/10.21203/rs.3.rs-2097342/v1
Autor:
Peter Clifton, David Sullivan, John Baker, Christian Schwabe, Susan Thackwray, Russell Scott, James Hamilton, Armando J Lira Pineda, Bruce Given, Stacey Melquist, Iris Chen, Javier San Martin, Gerald F Watts, Ira J Goldberg, Josh Knowles, Daniel Gaudet, Robert A Hegele, Christie M Ballantyne
Publikováno v:
Circulation. 144
Background: Familial chylomicronemia syndrome (FCS) is an ultrarare condition caused by biallelic pathogenic DNA variants in lipolysis-associated genes, resulting in severe hypertriglyceridemia (HTG) and associated with high risk of acute pancreatiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ded16ea5fecbafc320ab5faaa829707
https://doi.org/10.1161/circ.144.suppl_1.10357
https://doi.org/10.1161/circ.144.suppl_1.10357
Autor:
Gerald F. Watts, James D. Hamilton, Christian Schwabe, Robert A. Hegele, Stacey Melquist, Bruce D. Given, David R. Sullivan, N. Rajicic, Ira J. Goldberg, John M. Baker, Peter M. Clifton, Christie M. Ballantyne, Patrick Gladding, Russell S. Scott, Joshua W. Knowles, Daniel Gaudet, Javier San Martin, Ting Chang
Publikováno v:
Circulation. 142
Background: Angiopoietin-like protein 3 (ANGPTL3) regulates triglyceride (TG) and lipoprotein (LP) metabolism by inhibiting liver and endothelial LP lipases and reduces plasma LDL-C. In Phase 1 Study AROANG1001 (NCT03747224), single and multiple dose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0243379c3714387a6022cff1bb8daa06
https://doi.org/10.1161/circ.142.suppl_3.15751
https://doi.org/10.1161/circ.142.suppl_3.15751
Autor:
Christie M. Ballantyne, Robert A. Hegele, Gerald F. Watts, Stacey Melquist, Ting Chang, Christian Schwabe, Ira J. Goldberg, Russell S. Scott, Peter M. Clifton, Susan Thackwray, Josh Knowles, John M. Baker, Bruce D. Given, N. Rajicic, David R. Sullivan, James D. Hamilton, Javier San Martin, Daniel Gaudet
Publikováno v:
Circulation. 142
Background: Hypertriglyceridemia (HTG) increases the risk of acute pancreatitis and atherosclerosis. In a Phase 1 study (NCT03783377), single subcutaneous doses of investigational RNA interference (RNAi) therapeutic ARO-APOC3 (10, 25, 50, and 100 mg;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5a0ab34ba5c1f9f811e0afa1294eefd
https://doi.org/10.1161/circ.142.suppl_3.12594
https://doi.org/10.1161/circ.142.suppl_3.12594
Autor:
James D. Hamilton, Rob Hegele, Christian Schwabe, Ira J. Goldberg, Christie M. Ballantyne, Joshua W. Knowles, P Clifton, Gerald F. Watts, Russell S. Scott, Bruce D. Given, John Richard Baker, Stacey Melquist, J San Martin, D. Sullivan
Publikováno v:
European Heart Journal. 41
Background Individuals with triglycerides (TGs) ≥1,000 mg/dL (11.1 mmol/L) are at increased risk of acute pancreatitis. Genetic studies indicate that individuals with apolipoprotein C-3 (APOC3) loss-of-function mutations have low TGs, reduced cardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7a2c0030f775e2c4b18822155de7415
https://doi.org/10.1093/ehjci/ehaa946.3330
https://doi.org/10.1093/ehjci/ehaa946.3330
Autor:
James D. Hamilton, Russell S. Scott, John Richard Baker, Joshua W. Knowles, Gerald F. Watts, Patrick Gladding, Ira J. Goldberg, Christian Schwabe, Stacey Melquist, P Clifton, Rob Hegele, J San Martin, D. Sullivan, Bruce D. Given, Christie M. Ballantyne
Publikováno v:
European Heart Journal. 41
Background Elevated LDL-C and triglyceride rich lipoproteins (TRLs) are independent risk factors for cardiovascular disease (CVD). Genetic deficiency of angiopoietin-like protein 3 (ANGPTL3) is associated with reduced circulating levels of LDL-C, tri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e34b35f10f98083c6f47c21bf8dd985b
https://doi.org/10.1093/ehjci/ehaa946.3331
https://doi.org/10.1093/ehjci/ehaa946.3331
Autor:
Patricia Miller, Yaode Wang, Joseph Della Rocca, Jeffrey L. Evelhoch, Paul J. Coleman, Kerry Riffel, Zhizhen Zeng, Elizabeth Joshi, Kun Yang, Xiaoping Zhang, Kerim Babaoglu, Eric D. Hostetler, Talakad G. Lohith, Stacey O'Malley, David Hesk, Abbas Walji, Jaume Balsells, Mona Purcell, Jing Li, Serena Xu, Brett Connolly, Stacey Melquist, Arie Struyk, Jianmin Fu, Julie A. O'Brien, Marie A. Holahan, Harold G. Selnick, Fred Hess, Aimie Ogawa, David J. Schenk, Idriss Bennacef, Cristian Salinas, Joel B. Schachter, Aileen Soriano, Liza Gantert
Publikováno v:
Journal of Medicinal Chemistry. 59:4778-4789
Neurofibrillary tangles (NFTs) made up of aggregated tau protein have been identified as the pathologic hallmark of several neurodegenerative diseases including Alzheimer's disease. In vivo detection of NFTs using PET imaging represents a unique oppo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a39b60a8ba41ad44ebe7487bf9b6714d
https://doi.org/10.1021/acs.jmedchem.6b00166
https://doi.org/10.1021/acs.jmedchem.6b00166
Autor:
Josh Knowles, James A. Hamilton, Daniel Gaudet, Gerald F. Watts, Christian Schwabe, Javier San Martin, Bruce D. Given, Christie M. Ballantyne, John M. Baker, Stacey Melquist, Peter M. Clifton, Rob Hegele, David R. Sullivan, Ira J. Goldberg, Russell S. Scott, Susan Thackwray
Publikováno v:
Journal of Clinical Lipidology. 14:594
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2924933412fe25356f89bf1a39688c68
https://doi.org/10.1016/j.jacl.2020.05.078
https://doi.org/10.1016/j.jacl.2020.05.078