Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Stacey LaVoie"'
Autor:
Olivier Rogel, Tommasi Ruben A, J. R. Doughty, James Fang, Robert Goldstein, Raviraj Kulathila, Clayton Springer, Kirk Clark, Vishwas Ganu, Sven Weiler, Lijuan Zhu, Mark Chambers, Marc Walker, Stacey LaVoie, Jonathan E. Grob, Leslie Wighton Mcquire, Michael Shultz, Ronald L. Goldberg, Richard Melton, William Macchia, Jing Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6440-6445
The matrix metalloproteinase enzyme MMP-13 plays a key role in the degradation of type II collagen in cartilage and bone in osteoarthritis (OA). An effective MMP-13 inhibitor would provide a disease modifying therapy for the treatment of arthritis, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::637368f05820c0a9d88d5d7b4050753a
https://doi.org/10.1016/j.bmcl.2011.08.087
https://doi.org/10.1016/j.bmcl.2011.08.087
Autor:
David Farley, Leslie Wighton Mcquire, Karen Toscano, Noela Reel, Song Xue, James Fang, Elizabeth Quadros, Ronald L. Goldberg, J. R. Doughty, Siyuan Zhou, Robert Goldstein, Raviraj Kulathila, Joseph Somers, Gary Pastor, V. Blancuzzi, H. N. Singh, Stacey LaVoie, Robert A. Doti, Lauren G. Monovich, Kirk Clark, Tommasi Ruben A, Dennis M. Roland, John Fitt, Lijuan Zhu, Elizabeth O'Byrne, Vishwas Ganu, Jerry W. Skiles, Wen-Chung Shieh, David Thomas Parker, Theodore C. Pellas, Yumi Sakane, Andrew Wigg, Wendy D. Cornell, Richard Melton, William Macchia, Roger Aki Fujimoto
Publikováno v:
Journal of Medicinal Chemistry. 52:3523-3538
The matrix metalloproteinase enzyme MMP-13 plays a key role in the degradation of type II collagen in cartilage and bone in osteoarthritis (OA). An effective MMP-13 inhibitor would therefore be a novel disease modifying therapy for the treatment of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::180003a136c55f74b0ef18c43fb4d04e
https://doi.org/10.1021/jm801394m
https://doi.org/10.1021/jm801394m
Autor:
Lauren G. Monovich, Stacey LaVoie, William C. Boyar, Zhengming Du, Daniel LaSala, Elizabeth Quadros, Paul M. Steed, Tommasi Ruben A, Eugene Liu, Karen Toscano, Benjamin Biro Mugrage
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(8)
Halopemide, which was identified by HTS to inhibit phospholipase D2 (PLD2), provided the basis for an exploratory effort to identify potent inhibitors of PLD2 for use as inflammatory mediators. Parallel synthesis and purification were utilized to rap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a23ad9ed7f74a3aab7600b9e9aa1b9
https://pubmed.ncbi.nlm.nih.gov/17317170
https://pubmed.ncbi.nlm.nih.gov/17317170
Autor:
Lauren G. Monovich, Ruben A. Tommasi, Roger A. Fujimoto, Vincent Blancuzzi, Kirk Clark, Wendy D. Cornell, Robert Doti, John Doughty, James Fang, David Farley, John Fitt, Vishwas Ganu, Ronald Goldberg, Robert Goldstein, Stacey Lavoie, Raviraj Kulathila, William Macchia, David T. Parker, Richard Melton, Elizabeth O’Byrne
Publikováno v:
Journal of Medicinal Chemistry; Jun2009, Vol. 52 Issue 11, p3523-3538, 16p