Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Stacey L. Holman"'
Autor:
Jack R. T. Darby, Dimitra Flouri, Steven K. S. Cho, Georgia K. Williams, Stacey L. Holman, Ashley S. Meakin, Michael D. Wiese, Anna L. David, Christopher K. Macgowan, Mike Seed, Andrew Melbourne, Janna L. Morrison
Publikováno v:
Experimental Physiology, Vol 109, Iss 6, Pp 980-991 (2024)
Abstract Increasing placental perfusion (PP) could improve outcomes of growth‐restricted fetuses. One way of increasing PP may be by using phosphodiesterase (PDE)‐5 inhibitors, which induce vasodilatation of vascular beds. We used a combination o
Externí odkaz:
https://doaj.org/article/b70c5383fcda4f8096488728f82dba8b
Autor:
Catherine G. Dimasi, Jack R.T. Darby, Stacey L. Holman, Megan Quinn, Ashley S. Meakin, Mike Seed, Michael D. Wiese, Janna L. Morrison
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 9, Iss , Pp 100084- (2024)
The adult mammalian heart is unable to undergo cardiac repair, limiting potential treatment options after cardiac damage. However, the fetal heart is capable of cardiac repair. In preparation for birth, cardiomyocytes (CMs) undergo major maturational
Externí odkaz:
https://doaj.org/article/8427c37efa0b490491bc69d8bc2e0bf9
Autor:
Jack R. T. Darby, Brahmdeep S. Saini, Stacey L. Holman, Sarah J. Hammond, Sunthara Rajan Perumal, Christopher K. Macgowan, Mike Seed, Janna L. Morrison
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
IntroductionThe fetal haemodynamic response to acute episodes of hypoxaemia are well characterised. However, how these responses change when the hypoxaemia becomes more chronic in nature such as that associated with fetal growth restriction (FGR), is
Externí odkaz:
https://doaj.org/article/3e5e45377bfd4531afb0d08f7547afd1
Autor:
Jack R.T. Darby, Song Zhang, Stacey L. Holman, Beverly S. Muhlhausler, I. Caroline McMillen, Janna L. Morrison
Publikováno v:
Heliyon, Vol 9, Iss 7, Pp e18292- (2023)
Aims: To evaluate the effects of fetal glucose infusion in late gestation on the mRNA expression and protein abundance of molecules involved in the regulation of cardiac growth and metabolism. Main methods: Either saline or glucose was infused into f
Externí odkaz:
https://doaj.org/article/a6c82627e4084b309edf9542b293c617
Autor:
Jack R. T. Darby, Georgia K. Williams, Steven K. S. Cho, Ashley S. Meakin, Stacey L. Holman, Megan Quinn, Michael D. Wiese, Christopher K. Macgowan, Mike Seed, Janna L. Morrison
Publikováno v:
Physiological Reports, Vol 11, Iss 12, Pp n/a-n/a (2023)
Abstract Babies born growth restricted are at an increased risk of both poor short‐and long‐term outcomes. Current interventions to improve fetal growth are ineffective and do not lower the lifetime risk of poor health status. Maternal resveratro
Externí odkaz:
https://doaj.org/article/97005ba9184b4e3eb4484b0a9f643b81
Autor:
Dimitra Flouri, Jack R. T. Darby, Stacey L. Holman, Steven K. S. Cho, Catherine G. Dimasi, Sunthara R. Perumal, Sebastien Ourselin, Rosalind Aughwane, Nada Mufti, Christopher K. Macgowan, Mike Seed, Anna L. David, Andrew Melbourne, Janna L. Morrison
Publikováno v:
Advanced Science, Vol 9, Iss 30, Pp n/a-n/a (2022)
Abstract Magnetic resonance imaging (MRI) assessment of fetal blood oxygen saturation (SO2) can transform the clinical management of high‐risk pregnancies affected by fetal growth restriction (FGR). Here, a novel MRI method assesses the feasibility
Externí odkaz:
https://doaj.org/article/41d944f0f2624c8aa1881cb341321ea5
Autor:
Eric M. Schrauben, Jack R. T. Darby, Mary J. Berry, Brahmdeep S. Saini, Megan Quinn, Stacey L. Holman, Emma L. Bradshaw, Mitchell C. Lock, Sunthara R. Perumal, Steven K. S. Cho, Tanroop Aujla, Mike Seed, Christopher K. Macgowan, Janna L. Morrison
Publikováno v:
Physiological Reports, Vol 9, Iss 17, Pp n/a-n/a (2021)
Abstract The ductus arteriosus (DA) functionally closes during the transition from fetal to postnatal life because of lung aeration and corresponding cardiovascular changes. The thorough and explicit measurement and visualization of the right and lef
Externí odkaz:
https://doaj.org/article/dd843328b05b4f098c3539acbd75d33e
Autor:
Alex J. Charest‐Pekeski, Ayman Sheta, Luiza Taniguchi, Mark J. McVey, Alejandro Floh, Liqun Sun, Tanroop Aujla, Steven K. S. Cho, Jiaqi Ren, Lynn Crawford‐Lean, Celeste Foreman, Jessie Mei Lim, Brahmdeep S. Saini, Marvin Estrada, Anson Lam, Jaques Belik, Dariusz Mroczek, Megan Quinn, Stacey L. Holman, Jack R. T. Darby, Mike Seed, Janna L. Morrison, Christoph Haller
Publikováno v:
Physiological Reports, Vol 9, Iss 5, Pp n/a-n/a (2021)
Abstract Artificial placenta (AP) technology aims to maintain fetal circulation, while promoting the physiologic development of organs. Recent reports of experiments performed in sheep indicate the intrauterine environment can be recreated through th
Externí odkaz:
https://doaj.org/article/4a67c59c7e9e4625b317ec95d5376ee3
Autor:
Tamara J. Varcoe, Jack R. T. Darby, Stacey L. Holman, Emma L. Bradshaw, Tim Kuchel, Lewis Vaughan, Michael Seed, Michael D. Wiese, Janna L. Morrison
Publikováno v:
Physiological Reports, Vol 8, Iss 3, Pp n/a-n/a (2020)
Abstract Preclinical imaging studies of fetal hemodynamics require anesthesia to immobilize the animal. This may induce cardiovascular depression and confound measures under investigation. We compared the impact of four anesthetic regimes upon matern
Externí odkaz:
https://doaj.org/article/a3711c5f9dd84c568ddfc82d83f5b0d9
Autor:
Janna L. Morrison, Georgia K. Williams, Steven K.S. Cho, Brahmdeep S. Saini, Ashley S. Meakin, Stacey L. Holman, Megan Quinn, Michael D. Wiese, Christopher K. Macgowan, Mike Seed, Jack R.T. Darby
Publikováno v:
Neonatology. 119:735-744
Introduction: Newborns exposed to sildenafil citrate (SC) in utero have increased rates of persistent pulmonary hypertension. The mechanism behind this has not yet been fully elucidated. We aimed to utilize a combination of clinically relevant MRI te