Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Stacey L, Wilber"'
Autor:
Stacey L. Wilber, Katlyn A. Fleming, Carrie Haskell-Luevano, Mary M. Lunzer, Danielle N. Adank, Mark D. Ericson, Zoe M Koeperich
Publikováno v:
ACS Chem Neurosci
There is a critical need to find safe therapeutics to treat an increasingly obese population and diseases associated with an imbalance in energy homeostasis. The melanocortin-3 receptor (MC3R) and melanocortin-4 receptor (MC4R) ligands have long been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104e4d2d9e9fe36b34a6d903e803b669
https://doi.org/10.1021/acschemneuro.0c00409
https://doi.org/10.1021/acschemneuro.0c00409
Autor:
Katie T. Freeman, Jay W. Schaub, Stacey L. Wilber, Carrie Haskell-Luevano, Cody J. Lensing, Marvin L. Dirain, Srinivasa R. Tala, Viktor Flores, Mark D. Ericson, Erica M. Haslach, Branden A. Smeester, Robert C. Speth, Natalie Eick, Anamika Singh, Danielle N. Adank
Publikováno v:
Journal of Medicinal Chemistry. 61:3738-3744
β-Defensin 3 (BD3) was identified as a ligand for the melanocortin receptors (MCRs) in 2007, although the pharmacology activity of BD3 has not been clearly elucidated. Herein, it is demonstrated that human BD3 and mouse BD3 are full micromolar agoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8841371d1b4bc5a5b7bca6f8012e9077
https://doi.org/10.1021/acs.jmedchem.8b00251
https://doi.org/10.1021/acs.jmedchem.8b00251
Autor:
Carrie Haskell-Luevano, Katlyn A. Fleming, Danielle N. Adank, Stacey L. Wilber, Mary M. Lunzer, Mark D. Ericson, Katie T. Freeman
Publikováno v:
ACS Chemical Neuroscience. 9:1141-1151
The melanocortin system has five receptors and antagonists of the central melanocortin receptors (MC3R, MC4R) are postulated to be viable therapeutics for disorders of negative energy balance such as anorexia, cachexia, and failure to thrive. Agouti-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f069d87d8eee4249a4a4200edc204f3
https://doi.org/10.1021/acschemneuro.7b00495
https://doi.org/10.1021/acschemneuro.7b00495
Autor:
Danielle N. Adank, Katie T. Freeman, Sathya M. Schnell, Carrie Haskell-Luevano, Cody J. Lensing, Stacey L. Wilber, Adam T. Zarth, Robert C. Speth
Publikováno v:
ACS Chemical Neuroscience. 8:1262-1278
Bivalent ligands targeting putative melanocortin receptor dimers have been developed and characterized in vitro; however, studies of their functional in vivo effects have been limited. The current report compares the effects of homobivalent ligand CJ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf822f5056ea058ee2e6a891d1302b54
https://doi.org/10.1021/acschemneuro.6b00399
https://doi.org/10.1021/acschemneuro.6b00399
Autor:
Amy M. Gancarz, Mary M. Lunzer, Stacey L. Wilber, Carrie Haskell-Luevano, Cody J. Lensing, Danielle N. Adank
Publikováno v:
ACS chemical neuroscience. 9(2)
Central administration of melanocortin ligands has been used as a critical technique to study energy homeostasis. While intracerebroventricular (ICV) injection is the most commonly used method during these investigations, intrathecal (IT) injection c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5db859190ed75ad111c1383d6eba5f3
https://pubmed.ncbi.nlm.nih.gov/28968061
https://pubmed.ncbi.nlm.nih.gov/28968061
Autor:
Cody J, Lensing, Danielle N, Adank, Stacey L, Wilber, Katie T, Freeman, Sathya M, Schnell, Robert C, Speth, Adam T, Zarth, Carrie, Haskell-Luevano
Publikováno v:
ACS chemical neuroscience. 8(6)
Bivalent ligands targeting putative melanocortin receptor dimers have been developed and characterized in vitro, however studies of their functional in vivo effects have been limited. The current report compares the effects of homobivalent ligand CJL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::088ec26e14e4b0a38b55fa174b5b03b8
https://pubmed.ncbi.nlm.nih.gov/28128928
https://pubmed.ncbi.nlm.nih.gov/28128928