TET2 is a component of the estrogen receptor complex and controls 5mC to 5hmC conversion at estrogen receptor cis-regulatory regions

Autor: Carmen Gonzalez Tejedo, Kamal Kishore, Areeb Mahtey, Shi-Qing Mao, Clive D'Santos, Stacey Jamieson, Arnoud J. Groen, Rebecca Broome, Shankar Balasubramanian, Rasmus Siersbæk, Igor Chernukhin, Evangelia K. Papachristou, Vasiliki Theodorou, Anca M. Farcas, Jason S. Carroll

Publikováno v: Cell Reports, Vol 34, Iss 8, Pp 108776-(2021)
Broome, R, Chernukhin, I, Jamieson, S, Kishore, K, Papachristou, E K, Mao, S-Q, Tejedo, C G, Mahtey, A, Theodorou, V, Groen, A J, D'Santos, C, Balasubramanian, S, Farcas, A M, Siersbaek, R & Carroll, J S 2021, ' TET2 is a component of the estrogen receptor complex and controls 5mC to 5hmC conversion at estrogen receptor cis-regulatory regions ', Cell Reports, vol. 34, no. 8, 108776 . https://doi.org/10.1016/j.celrep.2021.108776
Cell Reports

Summary Estrogen receptor-α (ER) drives tumor development in ER-positive (ER+) breast cancer. The transcription factor GATA3 has been closely linked to ER function, but its precise role in this setting remains unclear. Quantitative proteomics was us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::855ab63375b08c0e118cc34f14f6e503
http://www.sciencedirect.com/science/article/pii/S2211124721000899

The FOXL2 C134W mutation is characteristic of adult granulosa cell tumors of the ovary

Autor: Markku Heikinheimo, Maria Alexiadis, Mikko Anttonen, Ralf Bützow, Noora Andersson, Peter J. Fuller, Leila Unkila-Kallio, Stacey Jamieson

Publikováno v: Modern Pathology. 23:1477-1485

Granulosa cell tumors of the ovary represent ∼5% of malignant ovarian cancers. It has recently been reported that 95-97% of adult granulosa cell tumors carry a unique somatic mutation in the FOXL2 gene. We undertook this study to verify the presenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::595cb06e502a2a4094051df9278fc362
https://doi.org/10.1038/modpathol.2010.145

Expression status and mutational analysis of the ras and B-raf genes in ovarian granulosa cell and epithelial tumors

Autor: Stacey Jamieson, Peter J. Fuller, Maria Alexiadis

Publikováno v: Gynecologic Oncology. 95:603-609

Objectives. The molecular pathogenesis of granulosa cell tumors of the ovary (GCT) is not understood. Activating mutations in the K-, N-, and H-ras protooncogenes have been identified in a wide range of human cancers, including ovarian epithelial tum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14752ed4578eb84c8f7b5fe228de9d28
https://doi.org/10.1016/j.ygyno.2004.07.062

Nuclear receptor profiling of ovarian granulosa cell tumors

Autor: Simon Chu, Peter J. Fuller, George E.O. Muscat, Colin Clyne, Ann E. Drummond, Stacey Jamieson, Natalie A. Eriksson, Melissa J. Davis, Maria Alexiadis

Publikováno v: Hormonescancer. 2(3)

Granulosa cell tumors of the ovary (GCT) represent ~5% of malignant ovarian tumors. The adult form is defined by a mutation in the FOXL2 gene. GCT exhibit many of the features of normal proliferating granulosa cells. We have profiled the expression o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c2a150fec956dd53b4cba122b50bb1
https://pubmed.ncbi.nlm.nih.gov/21761343

Adrenal gland tumorigenesis after gonadectomy in mice is a complex genetic trait driven by epistatic loci

Autor: Timothy J. Aitman, Ilpo T. Huhtaniemi, Anuj Goel, Sophie Bernichtein, Stacey Jamieson, Enrico Petretto, Jonathan Mangion

Publikováno v: Bernichtein, S, Petretto, E, Jamieson, S, Goel, A, Aitman, T J, Mangion, J M & Huhtaniemi, I T 2008, ' Adrenal gland tumorigenesis after gonadectomy in mice is a complex genetic trait driven by epistatic loci ', Endocrinology, vol. 149, no. 2, pp. 651-61 . https://doi.org/10.1210/en.2007-0925

Postgonadectomy adrenocortical tumorigenesis is a strain-specific phenomenon in inbred mice, assumed to be caused by elevated LH secretion and subsequent ectopic LH receptor (LHR) overexpression in adrenal gland. However, the molecular mechanisms of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2515d66c74d77d79bd55f4cf890280c3
https://pubmed.ncbi.nlm.nih.gov/18006632