Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Stacey E. Brenner"'
Autor:
Ana De Oliveira Silva, Jordan L. Harper, Katherine N. Fuhr, Roger A. Lalancette, Paul Ha-Yeon Cheong, Stacey E. Brenner-Moyer
Publikováno v:
The Journal of Organic Chemistry. 87:10105-10113
This Claisen rearrangement establishes the feasibility of DyKAT of γ-epimeric enals via dienamine formation to afford enantioenriched products. γ-Aryl and -alkyl enals, and exocyclic enals that introduce quaternary centers, are all amenable substra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::548783aa7437c33f492d11ae3054152b
https://doi.org/10.1021/acs.joc.2c01079
https://doi.org/10.1021/acs.joc.2c01079
Autor:
Guang Hu, Stacey E. Brenner-Moyer
Publikováno v:
The Journal of organic chemistry. 87(1)
A catalytic enantioselective deconjugative allylation of enals is reported. A variety of enals underwent this transformation in high yield and ee, and products can be readily transformed into γ-allyl enals via a Cope rearrangement without erosion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b35f53f5ad8acfb0a552967a87d7cd8c
https://pubmed.ncbi.nlm.nih.gov/34923821
https://pubmed.ncbi.nlm.nih.gov/34923821
Publikováno v:
Organicbiomolecular chemistry. 18(30)
Enantiopure compounds with a strategically incorporated fluorine atom intended to enhance LpxC inhibition have been synthesized using an organocascade fluorination reaction as the key step. These are the first low molecular weight LpxC inhibitors to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59842972f74e34cd1405a8ce68ca9d7b
https://pubmed.ncbi.nlm.nih.gov/32671374
https://pubmed.ncbi.nlm.nih.gov/32671374
Publikováno v:
Organic Letters. 19:6356-6359
The first catalytic enantioselective [5 + 2] dipolar cycloaddition of a 3-hydroxy-4-pyrone-derived oxidopyrylium ylide is described. These studies leveraged the recently recognized ability of oxidopyrylium dimers to serve as the source of ylide, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::083aec439b87b83604b47b7db08587d7
https://doi.org/10.1021/acs.orglett.7b03196
https://doi.org/10.1021/acs.orglett.7b03196
Publikováno v:
The Journal of Organic Chemistry. 82:6972-6977
An oxidative C–C cleavage of aldehydes requiring neither metals nor O2 was discovered. Homobenzylic aldehydes and α-substituted homobenzylic aldehydes were cleaved to benzylic aldehydes and ketones, respectively, using nitrosobenzene as an oxidant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13e08134f8fd975ba5b134a6d7c0d51e
https://doi.org/10.1021/acs.joc.7b00784
https://doi.org/10.1021/acs.joc.7b00784
Publikováno v:
The Journal of organic chemistry. 82(13)
An oxidative C-C cleavage of aldehydes requiring neither metals nor O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4f71975d40ce950de674a5ed1eacffd6
https://pubmed.ncbi.nlm.nih.gov/28589722
https://pubmed.ncbi.nlm.nih.gov/28589722
Publikováno v:
European Journal of Organic Chemistry. 2014:5273-5280
Chiral β-fluoro amines and β,β-difluoro amines are common substructures in medicinal compounds. Industrial syntheses typically use enantiopure starting materials, chiral auxiliaries, or the resolution of enantiomeric or diastereomeric mixtures to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3628508105b08093987eb85f3f46fcd5
https://doi.org/10.1002/ejoc.201402369
https://doi.org/10.1002/ejoc.201402369
Publikováno v:
Tetrahedron Letters. 56:4718-4720
Fluorinated, tetrasubstituted, carbon stereocenters are challenging to install enantioselectively. gem-Chlorofluoro compounds contain a fluorinated, tetrasubstituted stereocenter, and are an entree into other such compounds. We report herein the firs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3033f7227dfe20687263627101fd8f0
https://doi.org/10.1016/j.tetlet.2015.05.107
https://doi.org/10.1016/j.tetlet.2015.05.107
Publikováno v:
ChemInform. 47
A direct vinylogous Michael addition using linear vinylogous Michael donors has been developed. Notably, even γ-substituted Michael donors cleanly afforded γ-alkylated products in high yield and ee by this method. Moreover, control experiments reve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23c543793fd1428d481321e642c81e64
https://doi.org/10.1002/chin.201643047
https://doi.org/10.1002/chin.201643047
Publikováno v:
ChemInform. 47
The first catalytic method to directly introduce nitrone functionality onto aldehyde substrates is described. This reaction proceeds by an unprecedented organocatalytic redox mechanism in which an enal is oxidized to the γ-nitrone via dienamine cata
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66c5b510945e2ae9c96a19f713aa4d85
https://doi.org/10.1002/chin.201636055
https://doi.org/10.1002/chin.201636055