Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Stacey D Gilk"'
Publikováno v:
eLife, Vol 9 (2020)
Vector-borne illnesses comprise a significant portion of human maladies, representing 17% of global infections. Transmission of vector-borne pathogens to mammals primarily occurs by hematophagous arthropods. It is speculated that blood may provide a
Externí odkaz:
https://doaj.org/article/a7f1e591b75d41eb9337f90812d3beec
Publikováno v:
PLoS Pathogens, Vol 15, Iss 12, p e1007855 (2019)
Upon host cell infection, the obligate intracellular bacterium Coxiella burnetii resides and multiplies within the Coxiella-Containing Vacuole (CCV). The nascent CCV progresses through the endosomal maturation pathway into a phagolysosome, acquiring
Externí odkaz:
https://doaj.org/article/ab2f53ea6ca94c6d9659835d2a3ab061
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192215 (2018)
Coxiella burnetii is an obligate intracellular bacterial pathogen and a causative agent of culture-negative endocarditis. While C. burnetii initially infects alveolar macrophages, it has also been found in lipid droplet (LD)-containing foamy macropha
Externí odkaz:
https://doaj.org/article/919b4d2e9a894f7381e9edc9670b37c2
Autor:
Stacey D Gilk, Diane C Cockrell, Courtney Luterbach, Bryan Hansen, Leigh A Knodler, J Antonio Ibarra, Olivia Steele-Mortimer, Robert A Heinzen
Publikováno v:
PLoS Pathogens, Vol 9, Iss 1, p e1003107 (2013)
Reports implicating important roles for cholesterol and cholesterol-rich lipid rafts in host-pathogen interactions have largely employed sterol sequestering agents and biosynthesis inhibitors. Because the pleiotropic effects of these compounds can co
Externí odkaz:
https://doaj.org/article/58d2e455e4dc4a53adb01f82ccccfb9c
Autor:
Whittney Dotzler Barkhuff, Stacey D Gilk, Ryan Whitmarsh, Lucas D Tilley, Chris Hunter, Gary E Ward
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23977 (2011)
The inner membrane complex (IMC), a series of flattened vesicles at the periphery of apicomplexan parasites, is thought to be important for parasite shape, motility and replication, but few of the IMC proteins that function in these processes have be
Externí odkaz:
https://doaj.org/article/4bd4909e375a4c4ea80f5f46744eb346
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Obligate intracellular pathogens occupy one of two niches – free in the host cell cytoplasm or confined in a membrane-bound vacuole. Pathogens occupying membrane-bound vacuoles are sequestered from the innate immune system and have an extra layer o
Externí odkaz:
https://doaj.org/article/0300eed1fca143e492c4f47d72bb292a
Publikováno v:
mSphere, Vol 8, Iss 3 (2023)
ABSTRACT Coxiella burnetii is an intracellular bacterium that causes the human disease Q fever. C. burnetii forms a large, acidic Coxiella-containing vacuole (CCV) and uses a type 4B secretion system to secrete effector proteins into the host cell cy
Externí odkaz:
https://doaj.org/article/5ea826b99f4f4412adff959335aedb9b
Publikováno v:
bioRxiv
Coxiella burnetiiis a highly infectious pathogen that causes Q fever, a leading cause of culture-negative endocarditis.Coxiellafirst targets alveolar macrophages and forms a phagolysosome-like compartment called theCoxiella-ContainingVacuole (CCV). S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cf6cfad92879641b115068a22969861
https://doi.org/10.1101/2023.03.15.532774
https://doi.org/10.1101/2023.03.15.532774
Autor:
Stacey D. Gilk, I. Scott Ramsey, Yi Zhao, Christopher M. Robinson, Kristie R. Ross, Tatiana M. Clemente, Edward Simpson, Benjamin Gaston, Michael D Davis, Yunlong Liu, Rebekah S Cunningham, Laura Smith, Olivia K Giddings, Kirsten M. Kloepfer
Publikováno v:
Respir Care
BACKGROUND: Low airway surface pH is associated with many airway diseases, impairs antimicrobial host defense, and worsens airway inflammation. Inhaled Optate is designed to safely raise airway surface pH and is well tolerated in humans. Raising intr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19657df5da9f9b86ba5fc9ad5deb610f
https://doi.org/10.4187/respcare.08425
https://doi.org/10.4187/respcare.08425
Autor:
Tatiana M. Clemente, Rochelle Ratnayake, Dhritiman Samanta, Leonardo Augusto, Paul A. Beare, Robert A. Heinzen, Stacey D. Gilk
Publikováno v:
mBio
Coxiella burnetii replicates in a phagolysosome-like vacuole called the Coxiella-containing vacuole (CCV). While host cholesterol readily traffics to the CCV, cholesterol accumulation leads to CCV acidification and bacterial death. Thus, bacterial re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f170c3cf80d78add17833e4411ceb61b
https://doi.org/10.1128/mbio.03073-21
https://doi.org/10.1128/mbio.03073-21