Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Stacey B. B. Dutton"'
Publikováno v:
Current Sexual Health Reports. 11:167-175
This review investigates known research on ion channels expressed in the clitoris. Specifically, discussing the role these channels play in clitoral arousal, their contributions to sexual dysfunction, and their potential use as a pharmacological targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ddddebcf1783ce73af8943c9f441edc
https://doi.org/10.1007/s11930-019-00206-x
https://doi.org/10.1007/s11930-019-00206-x
Autor:
Jennifer C. Wong, Milen Velinov, Tyra Lamar, Stacey B. B. Dutton, Carlos G. Vanoye, Andrew Escayg, Jennifer A. Kearney, Jeffrey D. Calhoun, Benjamin S. Jorge
Publikováno v:
Neurobiology of Disease, Vol 102, Iss, Pp 38-48 (2017)
Mutations in voltage-gated sodium channels expressed highly in the brain (SCN1A, SCN2A, SCN3A, and SCN8A) are responsible for an increasing number of epilepsy syndromes. In particular, mutations in the SCN3A gene, encoding the pore-forming Nav1.3 α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::954b97b9101114e826827b2f50f209ec
https://doi.org/10.1016/j.nbd.2017.02.006
https://doi.org/10.1016/j.nbd.2017.02.006
Autor:
Ligia A. Papale, Karoni Dutt, Sandra L. Helmers, Alan L. Goldin, Stacey B. B. Dutton, Andrew Escayg
Publikováno v:
Dutton, SBB; Dutt, K; Papale, LA; Helmers, S; Goldin, AL; & Escayg, A. (2017). Early-life febrile seizures worsen adult phenotypes in Scn1a mutants. EXPERIMENTAL NEUROLOGY, 293, 159-171. doi: 10.1016/j.expneurol.2017.03.026. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/2d6880qf
Mutations in the voltage-gated sodium channel (VGSC) gene SCN1A, encoding the Nav1.1 channel, are responsible for a number of epilepsy disorders including genetic epilepsy with febrile seizures plus (GEFS+) and Dravet syndrome (DS). Patients with SCN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d22cd3d7c5aa5f5e7c0acbaae6ffefa7
https://europepmc.org/articles/PMC5538963/
https://europepmc.org/articles/PMC5538963/
Autor:
Nicolas A. Olivares, Andrew Escayg, John Gilchrist, Marcelo Diaz-Bustamante, Stacey B. B. Dutton, Jeet Kalia, Frank Bosmans, Annie J. McPherson
Publikováno v:
ACS Chemical Biology
Here, we report the discovery of a novel anticonvulsant drug with a molecular organization based on the unique scaffold of rufinamide, an anti-epileptic compound used in a clinical setting to treat severe epilepsy disorders such as Lennox-Gastaut syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b44abd17f3659a90d5f860e5949baa22
http://europepmc.org/articles/PMC4027953
http://europepmc.org/articles/PMC4027953
Autor:
Ligia A. Papale, Andrew Escayg, Stacey B. B. Dutton, Bindu Balakrishnan, Anupama Shankar, Christopher D. Makinson, Kazu Nakazawa
Publikováno v:
Neurobiology of Disease, Vol 49, Iss, Pp 211-220 (2013)
Voltage-gated sodium channels (VGSCs) are essential for the generation and propagation of action potentials in electrically excitable cells. Dominant mutations in SCN1A, which encodes the Nav1.1 VGSC α-subunit, underlie several forms of epilepsy, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::585be1261db4f0a9dddecb8b50a6886c
http://www.sciencedirect.com/science/article/pii/S0969996112002999
http://www.sciencedirect.com/science/article/pii/S0969996112002999
Publikováno v:
Frontiers in Pharmacology, Vol 7 (2016)
De novo loss-of-function mutations in the voltage-gated sodium channel (VGSC) SCN1A (encoding Nav1.1) are the main cause of Dravet syndrome (DS), a catastrophic early-life encephalopathy associated with prolonged and recurrent early-life febrile seiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4145fe717950a59907ee92a67dafc3f0
Publikováno v:
Frontiers in Pharmacology
De novo loss-of-function mutations in the voltage-gated sodium channel (VGSC) SCN1A (encoding Nav1.1) are the main cause of Dravet syndrome (DS), a catastrophic early-life encephalopathy associated with prolonged and recurrent early-life febrile seiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9f539947b476f9e833a0405bb4ae62a5
https://pubmed.ncbi.nlm.nih.gov/27799911
https://pubmed.ncbi.nlm.nih.gov/27799911
Autor:
Karin Borges, Stacey B. B. Dutton, Franck Kalume, Nikki T. Sawyer, William A. Catterall, Patricia Jumbo-Lucioni, Andrew Escayg
Publikováno v:
Epilepsia. 52:2050-2056
Purpose We evaluated the ability of the ketogenic diet (KD) to improve thresholds to flurothyl-induced seizures in two mouse lines with Scn1a mutations: one that models Dravet syndrome (DS) and another that models genetic (generalized) epilepsy with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eec47a693d8bb99f718a32f5d2b847f2
https://doi.org/10.1111/j.1528-1167.2011.03211.x
https://doi.org/10.1111/j.1528-1167.2011.03211.x
Publikováno v:
Molecular Immunology. 44:2737-2748
Two genes were identified in rainbow trout that display high sequence identity to vertebrate Lck. Both of the trout Lck transcripts are associated with lymphoid tissues and were found to be highly expressed in IgM-negative lymphocytes. In vitro analy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ebcfb66dd8464a5d175166e8b7390ac
https://doi.org/10.1016/j.molimm.2006.11.021
https://doi.org/10.1016/j.molimm.2006.11.021
Autor:
Stacey B. B. Dutton, Andrew Escayg
Publikováno v:
Epilepsia. 49:67-69
An average of 15-20% of patients on the ketogenic diet (KD) experience a >50% reduction in seizure frequency; however, 10-40% discontinue the diet due to either a lack of response or adverse side effects. This variability in patient response raises t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1791278d3a285af217ec2b7e7d814b71
https://doi.org/10.1111/j.1528-1167.2008.01839.x
https://doi.org/10.1111/j.1528-1167.2008.01839.x