Výsledky vyhledávání - "Stacey A. Lomenzo"

Halloysite-Catalyzed Esterification of Bio-Mass Derived Acids

Autor: Kaylin Kilgore, Brooke N. Diehl, Jumanah Hamdi, Mark L. Trudell, Stacey A. Lomenzo

Publikováno v: ACS Omega, Vol 4, Iss 21, Pp 19437-19441 (2019)
ACS Omega

Halloysite, a natural clay with a hollow tubular structure, was studied as a catalyst for the esterification of biomass-derived carboxylic acids (levulinic acid, fumaric acid, maleic acid, and succinic acid) with four different alcohols (MeOH, EtOH,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09d1c2bb4fd6fb898f56635ede93a1ef
https://pubmed.ncbi.nlm.nih.gov/31763567

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2-Substituted 3β-Aryltropane Cocaine Analogs Produce Atypical Effects without Inducing Inward-Facing Dopamine Transporter Conformations

Autor: Stacey A. Lomenzo, Jeffry D. Madura, Christopher K. Surratt, Lifen Xu, Theresa A. Kopajtic, Bernandie Jean, Mark L. Trudell, Jonathan L. Katz, Weimin C. Hong

Previous structure-activity relationship studies indicate that a series of cocaine analogs, 3β-aryltropanes with 2β-diarylmethoxy substituents, selectively bind to the dopamine transporter (DAT) with nanomolar affinities that are 10-fold greater th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d01fcfcd5b4345e0c57652c4c95ee072
https://europepmc.org/articles/PMC4767397/

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Regioselective synthesis and cannabinoid receptor binding affinity of N-alkylated 4,5-diaryl-1,2,3-triazoles

Autor: Mark L. Trudell, Stacey A. Lomenzo, Hong Shu, Sari Izenwasser, Dean Wade, Murali Papudippu, Steven P. Fournet, Edwin D. Stevens, Gerard Gulasey

Publikováno v: Medicinal Chemistry Research. 21:4473-4484

A series of N1- and N2-substituted 4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-1,2,3-triazoles were regioselectively synthesized to explore the binding motifs of the diaryl-1,2,3-triazole scaffold at CB1 receptors. The N1 analogs were regioselectively

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::30c32d82b58fde8384e26cafd4ecd847
https://doi.org/10.1007/s00044-012-9991-3

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Further structure–activity relationship studies on 8-substituted-3-[2-(diarylmethoxyethylidenyl)]-8-azabicyclo[3.2.1]octane derivatives at monoamine transporters

Autor: Dean Wade, Stacey A. Lomenzo, Abha Verma, Sari Izenwasser, Mark L. Trudell, Amy Housman, Shaine Cararas

Publikováno v: Bioorganic & Medicinal Chemistry. 19:7551-7558

The synthesis and structure-activity relationships of 8-substituted-3-[2-(diarylmethoxyethylidenyl)]-8-azabicyclo[3.2.1]octane derivatives were investigated at the dopamine transporter (DAT), the serotonin transporter (SERT) and norepinephrine transp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8350c3e7330e1ef03d19c66f9e9dd384
https://doi.org/10.1016/j.bmc.2011.10.028

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Synthesis and Monoamine Transporter Binding of 2-(Diarylmethoxymethyl)-3β-aryltropane Derivatives

Autor: Mark L. Trudell, Stacey A. Lomenzo, Lifen Xu, Theresa Kopajtic, Santosh S. Kulkarni, Jonathan L. Katz, Sari Izenwasser, and Amy Hauck Newman

Publikováno v: Journal of Medicinal Chemistry. 47:1676-1682

3 beta-Aryltropane analogues wherein the 2-position was substituted with various diarylmethoxyalkyl groups were synthesized and evaluated for binding at the dopamine transporter (DAT), serotonin transporter (SERT), norepinephrine transporter (NET), a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d959c5e1064216b621bd383cbd19fffc
https://doi.org/10.1021/jm030430a

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Synthesis and Biological Evaluation of 2-Substituted 3β-Tolyltropane Derivatives at Dopamine, Serotonin, and Norepinephrine Transporters

Autor: Cheryl Klein-Stevens, Naiju Zhu, Leyte L. Winfield, Stacey A. Lomenzo, Theresa Kopajtic, Mark L. Trudell, Jonathan L. Katz, Lifen Xu, Sari Izenwasser

Publikováno v: Journal of Medicinal Chemistry. 45:1203-1210

A series of eight 2-substituted 3-tolyltropane derivatives were synthesized, and the in vitro and in vivo biological activities as dopamine uptake inhibitors were determined. From the in vitro structure-activity data, it is apparent that a tolyl grou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7e1583a49efcf776ce66ee30eb8a2cc
https://doi.org/10.1021/jm010453u

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Regiospecific synthesis of 6-alkyltropan-2-ones

Autor: Stacey A. Lomenzo, Mark L. Trudell, Cheryl L. Klein, Naijue Zhu, Amy L. Bradley

Publikováno v: Journal of Heterocyclic Chemistry. 34:1139-1146

A new synthetic approach for the regiospecific alkylation of the 6-position of the tropane ring system has been developed. Alkylation, desulfonylation and deprotection of tropanes 5 and 12 furnished a series of 6-endo-alkyltropan-2-one derivatives 8a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01396081da157e715368178513293e28
https://doi.org/10.1002/jhet.5570340408

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3-Aryl-3-arylmethoxyazetidines. A new class of high affinity ligands for monoamine transporters

Autor: Sari Izenwasser, Stacey A. Lomenzo, Mark L. Trudell, Vivian R. Jaber, Amber Thaxton, Edwin D. Stevens, David L. Mobley, Dean Wade

Publikováno v: Bioorganicmedicinal chemistry letters. 23(15)

A series of 3-aryl-3-arylmethoxy-azetidines were synthesized and evaluated for binding affinities at dopamine and serotonin transporters. The 3-aryl-3-arylmethoxyazetidines were generally SERT selective with the dichloro substituted congener 7c (Ki =

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fea5677f55424561116bfaae55e1d199
https://pubmed.ncbi.nlm.nih.gov/23806554

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