Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Stacey A. Langan"'
Publikováno v:
Platelets, Vol 29, Iss 5, Pp 486-495 (2018)
Lymphatic endothelial cells (LEC) express the transmembrane receptor podoplanin whose only known endogenous ligand CLEC-2 is found on platelets. Both podoplanin and CLEC-2 are required for normal lymphangiogenesis as mice lacking either protein devel
Externí odkaz:
https://doaj.org/article/f71a51329dab4254a3058207774d5838
Autor:
Francesco Barone, Stacey A Langan, Alice Y. Pollitt, Steven A. Sheardown, Caetano Reis e Sousa, Cécile Bénézech, Leyre Navarro-Núñez, Edina Schweighoffer, Nicholas Smithers, Diego Mourão-Sá, Kate L. Lowe, Craig E. Hughes, Victor L. J. Tybulewicz, Gerard B. Nash, Steve P. Watson, Brenda A. Finney
Publikováno v:
Blood. 119:1747-1756
The C-type lectin receptor CLEC-2 signals through a pathway that is critically dependent on the tyrosine kinase Syk. We show that homozygous loss of either protein results in defects in brain vascular and lymphatic development, lung inflation, and pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ac1bfeb6b06c0faa1d752834e7204be
https://doi.org/10.1182/blood-2011-09-380709
https://doi.org/10.1182/blood-2011-09-380709
Publikováno v:
Thrombosis and haemostasis. 109(6)
SummaryCLEC-2 is a C-type lectin receptor which is highly expressed on platelets but also found at low levels on different immune cells. CLEC-2 elicits powerful platelet activation upon engagement by its endogenous ligand, the mucin-type glycoprotein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09c8543a1b850a25c96c0f4304296e4f
https://pubmed.ncbi.nlm.nih.gov/23572154
https://pubmed.ncbi.nlm.nih.gov/23572154