Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Stacey A. Heumann"'
Autor:
Tonika Bohnert, Brian T. Hopkins, Stig Hansen, Laura Silvian, Patrick Cullen, Min Zhong, Stacey A. Heumann, Junfa Fan, Noah Bell, Elisabeth Mertsching, Tracy J. Jenkins, Ella Negrou, Eris Bame, Douglas Marcotte, Kevin L. Otipoby, Michael J. Romanowski, Bob McDowell, Wenjin Yang, Daniel A. Erlanson, Patrick Conlon, Mark T. Cancilla, Minna Bui, Urjana Poreci, Daniel Scott, Tarra Fuchs-Knotts, Jon K. Bowden-Verhoek
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:2905-2913
Since the approval of ibrutinib for the treatment of B-cell malignancies in 2012, numerous clinical trials have been reported using covalent inhibitors to target Bruton's tyrosine kinase (BTK) for oncology indications. However, a formidable challenge
Autor:
Ella Negrou, Tracy J. Jenkins, Mark T. Cancilla, Douglas Marcotte, Minna Bui, Wenjin Yang, Brian T. Hopkins, Mukush Lulla, Daniel A. Erlanson, Eris Bame, Patrick Conlon, Stig Hansen, Elisabeth Mertsching, Tonika Bohnert, Noah Bell, Daniel Scott, Marx Isaac, Stacey A. Heumann, Junfa Fan, Ying Liu, Tarra Fuchs-Knotts, Laura Silvian, Chuck Gua, YuTing Liu, Jon K. Bowden-Verhoek, Michael J. Romanowski, Bob McDowell, Patrick Cullen, Min Zhong
Publikováno v:
Bioorganic & Medicinal Chemistry. 44:116275
Bruton's tyrosine kinase (BTK) is an essential node on the BCR signaling in B cells, which are clinically validated to play a critical role in B-cell lymphomas and various auto-immune diseases such as Multiple Sclerosis (MS), Pemphigus, and rheumatoi
Autor:
Willard Lew, Ute Hoch, Jeffrey A. Silverman, Stacey A. Heumann, Sheryl N. Ivy, Stuart Lam, Minna Bui, Hanan Emily, Thomas O'Brien, W. Michael Flanagan, Robert A. Elling, Bradley T. Tangonan, Hans E. Purkey, Heman Lee, Min Zhong, Subramanian Baskaran, Kristin M. Zimmerman, Pietro Taverna, Robert S. McDowell, Amy D. Fung, Wang Shen, Shannon O. Harris, Michael J. Romanowski, Wenjin Yang, Jeffrey W. Jacobs, Joshua C. Yoburn, Darin Allen, Chul Yu, Johan D. Oslob
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5158-5161
This Letter describes the discovery and key structure-activity relationship (SAR) of a series of 2-aminobenzimidazoles as potent Aurora kinase inhibitors. 2-Aminobenzimidazole serves as a bioisostere of the biaryl urea residue of SNS-314 (1c), which
Autor:
Subramanian Baskaran, Jeffrey A. Silverman, Jack Maung, Stacey A. Heumann, Hashash Ahmad, Johan D. Oslob, Robert S. McDowell, Willard Lew, Minna Bui, Chul Yu, Michael J. Romanowski, Tarra Fuchs-Knotts, Jeffrey W. Jacobs, Jonathan Hau, Wenjin Yang, Darin Allen, Min Zhong, Amy D. Fung, Sheryl N. Ivy, Erlie Marie Delarosa, Sean Ritchie
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(5)
Compound 1 (SNS-314) is a potent and selective Aurora kinase inhibitor that is currently in clinical trials in patients with advanced solid tumors. This communication describes the synthesis of prodrug derivatives of 1 with improved aqueous solubilit
Autor:
Stacey A. Heumann, Gary E. Keck
Publikováno v:
Organic letters. 10(21)
The pyridazinone ring system serves as an excellent scaffold for the diastereoselective preparation of novel cis-fused cyclopentapyridazinones utilizing the directed 5-exo radical cyclization approach. This overall approach was successfully employed
Autor:
Shannon O. Harris, Stacey A. Heumann, Jeffrey W. Jacobs, William Michael Flanagan, Subramanian Baskaran, Kristin M. Zimmerman, Darin Allen, Minna Bui, Michael J. Romanowski, Bradley T. Tangonan, Johan D. Oslob, Robert S. McDowell, Wang Shen, Chris E Lawrence, Juli N. Teague, Willard Lew, Michelle M. Sopko, Michelle A. Nannini, Jeffrey A. Silverman, Joshua C. Yoburn, Chul Yu, Min Zhong, Hanan Emily, Ute Hoch, Amy D. Fung, Joni Lam, Robert A. Elling, Thomas O'Brien
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(17)
This communication describes the discovery of a novel series of Aurora kinase inhibitors. Key SAR and critical binding elements are discussed. Some of the more advanced analogues potently inhibit cellular proliferation and induce phenotypes consisten
Autor:
Gary E. Keck, Stacey A. Heumann
Publikováno v:
Organic Letters; Oct2008, Vol. 10 Issue 21, p4783-4786, 4p